Low temperature injectable acrylic resin bone cement and its preparation method

Abstract

Disclosed are a cryogenically injectable acrylic bone cement and a preparation method therefor. The cryogenically injectable acrylic bone cement comprises a solid phase and a liquid phase, and the solid-liquid ratio of the solid phase to the liquid phase is 0.25-0.5 ml / g. The solid phase comprises 25-80 wt% of a component A and 20-75 wt% of a component B, in percentage by mass, wherein the component A comprises 59.5-99.5 wt% of powered acrylic polymers and 0.5-2 wt% of a peroxide initiator. The liquid phase comprises 95-99.9 vol% of acrylic monomers and 0.1-5 vol% of an promoter, in percentage by volume. The component B is particles prepared by mixing the component A and the liquid phase at a solid-liquid ratio of 0.25-0.8 ml / g. The cryogenically injectable acrylic bone cement has a low exothermic temperature during curing, has no new products introduced after curing, a smaller amount of residual monomers and good biocompatibility.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a low-temperature injectable acrylic resin bone cement and a preparation method thereof. Background technique [0002] Osteoporosis is one of the most common bone diseases in middle-aged and elderly people. The number of osteoporosis patients in my country is close to 100 million, and at least 210 million people have lower bone mass than normal, which is the country with the largest number and potential number of osteoporosis patients. A set of data published by the International Osteoporosis Foundation shows that an osteoporotic fracture occurs every 3 seconds in the world, 1 / 3 of women and 1 / 5 of men will suffer a fracture after the age of 50, 20% 100% of hip fracture patients die within 6 months of fracture, and half of patients are unable to take care of themselves. Injecting bone cement into injured bones or vertebrae is a relatively simple and effective method for trea...

AI Technical Summary

Problems solved by technology

For example, German Patent 3245956A1 discloses a bone cement based on liquid monomers and powdery polymerized acrylates and / or methacrylates, catalysts and accelerators. Surface active liquid can effectively reduce the heat released during bone cement polymerization, but the final product introduces surface active liquid, which limits clinical application; Chinese patent 104784753A discloses a composite bone cement that can reduce thermal necrosis effect, the bone cement powder A phase-change microcapsule material (PCM) was added to reduce the maximum temperature during curing, making it significantly lower than the clinical application requirements. Although it can reduce thermal necrosis, the final product has changed, and clinical application needs further verification.

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