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Materials for phototherapy of eye diseases

A technology of matrix material and photosensitizer, applied in the field of medical materials

Active Publication Date: 2021-07-30
EYEBRIGHT MEDICAL TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention provides medical materials for photodynamic therapy and photothermal therapy, which can solve the disadvantages of traditional photodynamic therapy and photothermal therapy

Method used

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  • Materials for phototherapy of eye diseases
  • Materials for phototherapy of eye diseases
  • Materials for phototherapy of eye diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0096] Embodiment 1a: the synthesis of methyl methacrylate-photosensitizer copolymerization material

[0097] In a 250ml beaker, add 98.0 g methyl methacrylate monomer (MMA), 2.0 g ethylene glycol dimethacrylate (EGDMA), 0.12 g initiator (azobisisobutyronitrile, AIBN), 0.04 g photosensitizer (purpurin 18), after fully stirring, transfer to the forming mold. After injecting nitrogen gas into the monomer solution, seal the mold, put it in a water bath at 65°C for 24 hours of polymerization reaction, and then transfer the mold to an oven at 90°C for 24 hours to obtain a photosensitive compound containing purpurin 18. Resistant polymethyl methacrylate material. The molecular structural formula of rhodopsin 18 is shown below. Since the molecular structure of purpurin 18 contains ethylenically unsaturated double bonds, it can be copolymerized with MMA and EGDMA, thereby fixing the photoactive porphyrin (tetrapyrrole ring structure) group in the PMMA molecular chain, and because EG...

Embodiment 1a-1x

[0100] Reaction condition is substantially identical with embodiment 1a, difference is as follows:

[0101] monomer combination Photosensitizer 1a MMA+EGDMA Purpurin 18 1b EA+EMA+EGDMA Pheophorbide a 1c MMA+BA+BDDMA Chlorin e4 1d EA+EMA+TFEMA+EGDMA Chlorin e6 1e PEA+PEMA+BDDMA Chlorin p6 1f EA+St+EGDMA Chlorin f 1g EA+MSt+HDDMA Methyl pheophorbide a 1h POEA+BMA+EGDMA Purpurin 18 methyl ester 1i POEA+EMA+BDDMA Chlorin e4 dimethyl ester 1j POEA+BA+St+EGDMA Chlorin e6 trimethyl ester 1k EA+EOEMA+HDDMA Chlorin p6 trimethyl ester 1l EA+EMA+EOEOEMA+BDDMA Chlorin f dimethyl ester 1m POEA+EGDMA protoporphyrin 1n St+DVB Protoporphyrin dimethyl ester 1o POEA+St+EGDMA Pheophytin a 1p HEMA+EGDMA disodium protoporphyrin 1q HEMA+MMA+EGDMA Fluorescein O-acrylate 1r HEA+EGDMA Purpurin 18 1s HEA+MMA+EGDMA Pheophorbide a 1t HEMA+...

Embodiment 2a

[0126] Embodiment 2a: the synthesis of silica gel-photosensitizer copolymerization material

[0127] In a 250ml beaker, add 0.04 g of purpurin 18 (photosensitizer) into the two-component silicone rubber system (MED-6820, purchased from Nusil), stir well and remove air bubbles, then transfer to the molding mold. The mold is sealed, and then placed in an oven at 150° C. for 30 minutes of polymerization reaction to obtain a silica gel material containing a purpurin 18 photosensitizer. Since the molecular structure of purpurin 18 contains ethylenically unsaturated double bonds, it can be copolymerized with hydrogen-containing silicone oil and vinyl silicone oil, thereby immobilizing the photoactive porphyrin (tetrapyrrole ring structure) group in the molecular chain of silica gel , so the photosensitizer (purpurin 18) molecules will be firmly fixed in the silicone material and cannot freely enter the blood or other body fluids.

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Abstract

The invention relates to a material for phototherapy of eye diseases, including a matrix material and a photosensitizer, wherein the photosensitizer is dispersed inside the matrix material by means of copolymerization or doping, or by surface grafting, or surface modification, or Surface coating and other methods are attached to the surface of the base material. The material can kill the cells in the diseased part under the irradiation of the laser with the selected wavelength, so as to achieve the effect of phototherapy for ophthalmic diseases. The invention also provides a manufacturing method of the material and its use in preparing ophthalmic medical equipment.

Description

technical field [0001] The invention relates to a medical material for phototherapy, especially an ophthalmic material for phototherapy for eye diseases and a preparation method thereof. Background technique [0002] Various eye diseases, such as eyelid disease, lacrimal disease, conjunctival disease, corneal disease, scleral disease, uveal disease, cataract, post-cataract, glaucoma, vitreous disease, lens disease, iris disease, retinal disease, macular degeneration , visual path disease, orbital disease, eye trauma, eye refraction, eye myopathy, eye tumor, etc., especially some intraocular diseases, can lead to blurred vision or even blindness of the patient, causing huge life losses to the patient. Inconvenient and painful. Due to the unique physiological structure of the human eye, many diseases can only be treated by surgery, and the structure of the human eye is very complicated, and the tissues in the eye are very fine and tiny, so the operation is very difficult, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61K41/00A61F9/00A61N5/06A61P27/02
CPCA61K41/0057A61K47/58A61K47/6957A61F9/0079A61K41/0071A61N5/062A61N2005/0648A61F9/008A61K41/0076
Inventor 隋信策魏永吉解江冰
Owner EYEBRIGHT MEDICAL TECH BEIJING