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Composition for treating hidradenitis suppurativa

A technology for hidradenitis suppurativa and a composition is applied in the field of biomedicine, which can solve the problems of strong side effects, easy repetition, and easy formation of drug resistance effects, and achieves the effects of no toxic side effects and skin immune function promotion.

Inactive Publication Date: 2017-05-17
BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the shortcomings of existing hidradenitis suppurativa treatment products, such as incomplete treatment, easy to repeat, strong side effects, easy to form drug resistance or ineffective effects, the present invention proposes a composition for treating hidradenitis suppurativa, It is characterized in that the composition comprises mussel soft tissue extract, trypsin, lactic acid and cinnamic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: The preparation method of mussel soft tissue extract.

[0033] Take mussels and remove their shells, collect 300 g of soft tissue, divide them into three parts, add 100 ml of the acidic solution in Table 1 below with a content of 0.3%, homogenate for 10 minutes, and centrifuge to obtain the supernatant, which is the mussel soft tissue extract.

[0034] The protein content and pH value in the supernatant were determined, and the protein content was determined by the Coomassie brilliant blue method.

[0035] Table 1

[0036] example acid solution protein content pH value 1 citric acid 2.6mg / ml 4.5 2 Acetic acid 3.5mg / ml 3.2 3 perchloric acid 3.0mg / ml 1.0

Embodiment 2

[0037] Embodiment 2: A composition spray of mussel soft tissue extract, trypsin, lactic acid and cinnamic acid.

[0038] The composition for treating hidradenitis suppurativa in this example is composed of the following proportions by weight: mussel soft tissue extract 10mg, trypsin 10mg, lactic acid 15mg and cinnamic acid 15mg, vitamin C: 15mg, licorice extract 3mg, Zinc gluconate 15mg, peppermint extract 3mg, add deionized water to fully dissolve to form a spray.

[0039] Eleven volunteers were collected to participate in the test, and the sprays of mussel soft tissue extract, trypsin, lactic acid and cinnamic acid were used, sprayed twice a day, 10 days as a course of treatment, and the recurrence was recorded within 1 month.

[0040] Criteria for judging curative effect: Curative effect observation indicators include skin lesions (papules, pustules, nodules, abscesses) and pain.

[0041] Recovery from illness: clinical control: symptoms and signs are improved by 100% (ski...

Embodiment 3

[0049] Embodiment 3: A composition ointment of mussel soft tissue extract, trypsin, lactic acid and cinnamic acid.

[0050] The composition for treating hidradenitis suppurativa in this example is composed of the following proportions by weight: mussel soft tissue extract 50mg, trypsin 30mg, lactic acid 25mg and cinnamic acid 25mg, vitamin C: 18mg, licorice extract 7mg, Zinc gluconate 25mg, peppermint extract 8mg, add petroleum jelly to make ointment.

[0051] 26 volunteers were collected to participate in the test and divided into two groups. The experimental group used the ointment made of mussel soft tissue extract, trypsin, lactic acid and cinnamic acid, and the control group used commercially available prednisone ointment, which was applied twice a day , 10 days as a course of treatment, return visit within 1 month and record the recurrence.

[0052] Criteria for judging curative effect: Curative effect observation indicators include skin lesions (papules, pustules, nodu...

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PUM

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Abstract

The invention relates to a composition for treating hidradenitis suppurativa. The composition comprises mussel soft tissue extract, trypsin, lactic acid, and cinnamic acid, and optionally, comprises other carriers. The composition has the beneficial effects that the composition of mussel soft tissue extract, trypsin, lactic acid, and cinnamic acid has the effects of anti-inflammatory, anti-allergy and analgesic; through adjusting skin immunity and promoting skin cell metabolism, the composition has good effects to pain and itching caused by hidradenitis suppurativa, and also can effectively release papule, pustule, nodule, abscess and other symptoms caused by hidradenitis suppurativa; the formula excludes glucocorticoids matter and antibiotic; after long-term use, the formula is free from dependency, toxic and side effects; the composition is high in safety and big in curing rate through clinical use.

Description

technical field [0001] The invention relates to the technical field of biomedicine, more specifically, to a composition for treating hidradenitis suppurativa. Background technique [0002] Hidradenitis suppurativa is a chronic suppurative inflammation of apocrine sweat glands, which often occurs in the distribution areas of apocrine sweat glands such as armpits, vulva, and around the anus. Mostly caused by Staphylococcus aureus, local hyperhidrosis, maceration, uncleanliness and trauma are common causes. These factors block the duct of the apocrine glands, followed by bacterial infection. After the infection of the apocrine glands, it occurs repeatedly in the intradermal and subcutaneous tissue, and spreads widely, forming a wide range of chronic inflammation, small abscesses, complex sinuses and fistulas. At the beginning, it was single or multiple intradermal or subcutaneous pea-sized inflammatory indurations, which later suppurated and formed fluctuating hemispherical ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P17/00A61P31/04A61K35/618A61K31/19A61K31/192A61K31/375A61K31/315A61K36/534
CPCA61K38/4826A61K31/19A61K31/192A61K31/315A61K31/375A61K35/618A61K36/484A61K36/534C12Y304/21004
Inventor 高敏
Owner BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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