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A kind of preparation method of desmodium granules

A technology of golden grass and granules, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of difficult granulation, difficulty in granulation, poor solubility, etc. The effect of reducing energy consumption, improving compliance, and reducing dosage

Active Publication Date: 2020-04-17
CHONGQING KERUI PHARMA GRP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the above-mentioned deficiencies in the prior art, the present invention solves the problems of low content of Desmodium granules and difficult granulation, and overcomes the problems of difficult granulation and poor solubility after removing sucrose in the process, and provides a Desmodium granule The preparation method of the preparation meets the needs of modern Chinese medicine

Method used

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  • A kind of preparation method of desmodium granules
  • A kind of preparation method of desmodium granules
  • A kind of preparation method of desmodium granules

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preparation example Construction

[0023] A preparation method of Desmodium sativa granules, comprising the following steps:

[0024] 1. Desmodium desmodium extract: Desmodium desmodium extract is extracted by forced dynamic circulation. The specific operation method is to take 400 parts by weight of desmodium herbaceous material, add water (90-95 ℃) to force dynamic circulation extraction three times, add 6 times the amount of water for the first time, Forced dynamic circulation extraction for 2 hours, add 4 times the amount of water for the second time, force dynamic circulation extraction for 1 hour, add 2 times the amount of water for the third time, force dynamic circulation extraction for 30 minutes, combine the extracts; let stand for 12 to 24 hours, take the The clear liquid is filtered; the filtrate is concentrated to 75 to 130 parts by weight of extract with a relative density of 1.10 to 1.25 at a temperature of 50 to 55°C;

[0025] 2. Add suitable pharmaceutical excipients and appropriate amount of f...

Embodiment 1

[0029] Desmodium 400g, add water (90-95°C) to extract three times with forced dynamic circulation, add 6 times the amount of water for the first time, and extract with forced dynamic circulation for 2 hours; add 4 times the amount of water for the second time, and extract with forced dynamic circulation for 1 hour; Add 2 times the amount of water, extract by forced dynamic circulation for 30 minutes; combine the extracts, let stand for 12 hours, take the supernatant, filter, and concentrate the filtrate to 75g of extract with a relative density of 1.10 at a temperature of 55°C, and the solid content is 30g; add 0.9g of polyvinylpyrrolidone and 0.6g of aspartame, stir well with a high-speed mixer, obtain a dry extract through a vacuum low-temperature continuous dryer (vacuum degree -0.09MPa, material temperature 60°C), and crush; add 75% Ethanol, granulated, passed through a 12-mesh sieve, made into wet granules, and dried at 65°C to obtain 31.2g of granules, which were divided ...

Embodiment 2

[0031]Desmodium 4000g, add water (90-95 ℃) to force dynamic circulation extraction three times, add 6 times of water for the first time, and force dynamic circulation to extract for 2 hours; add 4 times of water for the second time, and force dynamic circulation to extract for 1 hour; third time Add 2 times the amount of water, extract by forced dynamic circulation for 30 minutes; combine the extracts, let stand for 12 hours, take the supernatant, filter, and concentrate the filtrate to 1298g extract with a relative density of 1.10 at a temperature of 55°C, and the solid content is 498g; add 0.5g sodium carboxymethyl cellulose and 2.5g stevioside, stir evenly with a high-speed mixer, and obtain a dry extract through a vacuum low-temperature continuous dryer (vacuum degree -0.09MPa, material temperature 60°C, crushing particle size 80 mesh) Powder; add 75% ethanol, granulate, pass through a 12-mesh sieve to make wet granules, and dry at 65°C to obtain 500g of granules, which are...

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Abstract

The invention provides a preparation method of herba lysimachiae granules. The preparation method comprises the steps of adopting herba lysimachiae as a raw material; adopting water (90 to 95 DEG C) for forcedly and dynamically recycling extracting for three times; vacuum concentrating an extracting solution to obtain a herba lysimachiae extract; adding appropriate pharmaceutic adjuvant and appropriate amount of flavoring agent for highly dispersing, and then preparing to form mixed dry extract powder through a vacuum low-temperature continuous drying technology; adding ethyl alcohol for stirring and mixing to obtain the granules. According to the preparation method adopted by the invention, the contents of quercetin and kaempferide in the herba lysimachiae granules can be remarkably improved, and the increased range achieves 250 percent; the dosage of the commercially available herba lysimachiae granules for every time can be reduced by not less than 70 percent, so that the patient adaptability is greatly improved; the operation cost can be reduced by not less than 1 / 3, the energy consumption can be reduced by not less than 40 percent, and the modernization of a traditional Chinese medicine can be fully reflected.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a method for preparing desmodium sativa granules by taking desmodium as a raw material. Background technique [0002] Desmodium is a species recorded in the Pharmacopoeia of the People's Republic of China (2015 edition one), and it is the dry whole herb of Lysimachia christinae Hance, which is harvested in summer and autumn, removed from impurities, and dried in the sun. Desmodium is sweet, salty, slightly cold, and returns to the liver, gallbladder, kidney, and bladder meridian. Drenching, astringent pain in urination, carbuncle and furuncle, snake and insect bites. According to legend, Sichuan Baicaotang’s prescription transcripts, during the Qianlong period of the Qing Dynasty (1736-1795), there are records of the treatment of "yellow sand and jaundice" by the grass. It has been used for at least 200 years and is known as the key to c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/32A61K47/38A61P1/16A61P13/00A61P17/02A61P39/02
CPCA61K9/1635A61K9/1652A61K36/185A61K2236/331A61K2236/39A61K2236/51
Inventor 龙平刘俊敏吴华吕白桦林泉松陈正周在富
Owner CHONGQING KERUI PHARMA GRP
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