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Veterinary oxytetracycline hydrochloride chewable tablet and preparation method thereof

A technology of oxytetracycline hydrochloride and chewable tablets, which is applied in the formulation and preparation of new veterinary oxytetracycline hydrochloride chewable tablets, can solve the problems of convenience, safety and therapeutic effect, and improve the Effects of cure rate, avoidance of sticking to the wall, and promotion of feed intake

Inactive Publication Date: 2017-05-31
ZHUMADIAN HUAZHONG CHIA TAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used dosage forms of oxytetracycline hydrochloride on the market are mainly oxytetracycline hydrochloride soluble powder and oxytetracycline hydrochloride injection (for example, Chinese patent CN201310392138.6 discloses a preparation of oxytetracycline hydrochloride soluble powder technology, Chinese patent CN201110043820.5 discloses a compound oxytetracycline hydrochloride injection for veterinary use and its preparation method), etc., which have a great influence on the convenience, safety and therapeutic effect of the preparation, so it is urgent to develop a A new stable and efficient oxytetracycline hydrochloride product

Method used

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  • Veterinary oxytetracycline hydrochloride chewable tablet and preparation method thereof
  • Veterinary oxytetracycline hydrochloride chewable tablet and preparation method thereof
  • Veterinary oxytetracycline hydrochloride chewable tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] A oxytetracycline hydrochloride chewable tablet for animals, which comprises the following components in weight percentage: oxytetracycline hydrochloride 20%, aspartame 5%, corn starch 20%, maltodextrin 5%, microcrystalline cellulose 8 %, magnesium stearate 1%, talc powder 1%, anhydrous glucose 10%, skimmed milk powder 10%, citric acid 10%, niacinamide 10%.

[0020] The preparation method of above-mentioned oxytetracycline hydrochloride chewable tablet for animals, it comprises the steps:

[0021] 1) Material preparation: Dry cornstarch at 100°C for 1 hour, cool to room temperature: then dilute and mix aspartame and oxytetracycline hydrochloride respectively by equal volume incremental dilution method to obtain mixture A; mix mixture A with Mix cornstarch, maltodextrin, anhydrous glucose, skimmed milk powder, citric acid, and niacinamide evenly to obtain mixture B for later use;

[0022] 2) Granulation: add 45% water of mixture B to mixture B, stir evenly, add to granu...

Embodiment 2

[0025] A oxytetracycline hydrochloride chewable tablet for animals, which comprises the following components in weight percentage: oxytetracycline hydrochloride 10%, aspartame 3%, cornstarch 15%, maltodextrin 8%, microcrystalline cellulose 10% %, magnesium stearate 0.5%, talc powder 0.5%, anhydrous glucose 20%, skim milk powder 15%, citric acid 8%, niacinamide 10%.

[0026] For the preparation method of the oxytetracycline hydrochloride chewable tablet for animals, refer to Example 1.

Embodiment 3

[0028] A oxytetracycline hydrochloride chewable tablet for animals, which comprises the following components in weight percentage: oxytetracycline hydrochloride 5%, aspartame 1%, cornstarch 10%, maltodextrin 10%, microcrystalline cellulose 10% %, magnesium stearate 0.1%, talc powder 1%, anhydrous glucose 20%, skimmed milk powder 20%, citric acid 7.9%, niacinamide 15%.

[0029] For the preparation method of the oxytetracycline hydrochloride chewable tablet for animals, refer to Example 1.

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Abstract

The invention discloses a veterinary oxytetracycline hydrochloride chewable tablet. The chewable tablet is prepared from, by weight, 5-30% of oxytetracycline hydrochloride, 1-5% of aspartame, 10-30% of corn starch, 1-10% of maltodextrin, 1-10% of microcrystalline cellulose, 0.1-1% of magnesium stearate, 0.1-1% of talcum powder, 10-30% of anhydrous glucose, 10-30% of skim milk powder, 1-10% of citric acid and 1-30% of nicotinamide. The chewable tablet has advantages that the defect of poor palatability of existing chewable tablets is overcome, animals can chew and absorb the tables completely, and accordingly dosage is effectively guaranteed, veterinary disease cure rate is increased, and drug waste is reduced.

Description

technical field [0001] The invention belongs to the technical field of oxytetracycline hydrochloride preparations, and in particular relates to a formula of a novel veterinary oxytetracycline hydrochloride chewable tablet product and a preparation method thereof. Background technique [0002] Oxytetracycline hydrochloride, also known as oxytetracycline hydrochloride, oxytetracycline hydrochloride, or oxytetracycline hydrochloride, is an antibiotic widely used in humans and animals, and is clinically used to treat various diseases, such as rickettsiasis, including Epidemic typhus, endemic typhus, scrub typhus; infection caused by Mycoplasma pneumoniae; chlamydial infection, including psittacosis, venereal lymphoid edema, nonspecific urethritis, salpingitis, and trachoma; relapsing fever; Brucella disease; cholera; plague and tularemia, etc. [0003] At present, the commonly used dosage forms of oxytetracycline hydrochloride on the market are mainly oxytetracycline hydrochlor...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/65A61K47/12A61K47/22A61K47/26A61K47/46A61P11/00A61P1/12A61P31/04A61P43/00
CPCA61K9/0056A61K9/2013A61K9/2018A61K9/2054A61K9/2068A61K31/65
Inventor 李书至卜令军王文钰郭双樊春光商林
Owner ZHUMADIAN HUAZHONG CHIA TAI
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