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Long-acting healing-promoting artificial skin and preparation method thereof

An artificial skin, long-term technology, applied in the field of medical devices, to achieve the effect of short preparation time, simple method, and promoting cell growth

Active Publication Date: 2017-05-31
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The content of the present invention is to provide a long-acting healing-promoting artificial skin and its preparation method to solve the existing technical defects

Method used

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  • Long-acting healing-promoting artificial skin and preparation method thereof
  • Long-acting healing-promoting artificial skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method for long-acting healing-promoting artificial skin, comprising the following steps:

[0030] S1: Prepare 0.5 mol / L acetic acid solution: Dilute acetic acid with deionized water to obtain 0.5 mol / L acetic acid solution.

[0031] S2: Preparation of collagen and silk fibroin mixed gel: add collagen and silk fibroin to the 0.5mol / L acetic acid solution prepared in S1 to obtain a 20% collagen / silk fibroin mixed gel, in which collagen and silk fibroin The mass ratio is 1:1.

[0032] S3: Preparation of growth factor-loaded microspheres: D,L-polylactic acid (PDLLA), poly-L-lactic acid (PLLA) and polylactic-co-glycolic acid (PLGA) were added at a ratio of 2:1:1 Stir in 10ml of chloroform to obtain 50mg / ml polylactic acid solution, mix 10ml 50mg / ml polylactic acid solution with 1ml 5μg / ml PBS buffer solution containing growth factors, vortex the mixture for 1min to obtain colostrum, and 2ml of colostrum was added dropwise to 4ml of polyvinyl alcohol solution...

Embodiment 2

[0037] A preparation method for long-acting healing-promoting artificial skin, comprising the following steps:

[0038] S1: Prepare 0.5 mol / L acetic acid solution: Dilute acetic acid with deionized water to obtain 0.5 mol / L acetic acid solution.

[0039] S2: Preparation of collagen and silk fibroin mixed gel: add collagen and silk fibroin to the 0.5mol / L acetic acid solution prepared in S1 to obtain a 20% collagen / silk fibroin mixed gel, in which collagen and silk fibroin The mass ratio is 1:1.

[0040] S3: Preparation of microspheres loaded with growth factors: D,L-polylactic acid (PDLLA), poly-L-lactic acid (PLLA) and polylactic-co-glycolic acid (PLGA) were added in a ratio of 1:1:1 Stir in 10ml of chloroform to obtain a 50mg / ml polylactic acid solution, mix 10ml of 50mg / ml polylactic acid solution with 1ml of 5μg / ml PBS buffer solution containing growth factors, vortex the mixture for 1min to obtain colostrum, Add 2ml of colostrum dropwise to 4ml of polyvinyl alcohol solu...

Embodiment 3

[0045] A preparation method for long-acting healing-promoting artificial skin, comprising the following steps:

[0046] S1: Prepare 0.5 mol / L acetic acid solution: Dilute acetic acid with deionized water to obtain 0.5 mol / L acetic acid solution.

[0047] S2: Preparation of collagen and silk fibroin mixed gel: add collagen and silk fibroin to the 0.5mol / L acetic acid solution prepared in S1 to obtain a 20% collagen / silk fibroin mixed gel, in which collagen and silk fibroin The mass ratio is 1:1.

[0048] S3: Preparation of growth factor-loaded microspheres: D,L-polylactic acid (PDLLA), poly-L-lactic acid (PLLA) and polylactic-co-glycolic acid (PLGA) were added at a ratio of 1:1:2 Stir in 10ml of chloroform to obtain a 50mg / ml polylactic acid solution, mix 10ml of 50mg / ml polylactic acid solution with 1ml of 5μg / ml PBS buffer solution containing growth factors, vortex the mixture for 1min to obtain colostrum, Add 2ml of colostrum dropwise to 4ml of polyvinyl alcohol solution u...

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Abstract

The invention discloses long-acting healing-promoting artificial skin and a preparation method thereof. The long-acting healing-promoting artificial skin comprises a corium layer and an epidermal layer, wherein the corium layer is composed of collagen and silk fibroin; and growth factor supported microspheres are uniformly distributed on the corium layer. The epidermal layer is composed of a silicone gel layer on which pores are distributed; the silicone gel layer is composed of a silicone adhesive and a curing agent; and the pore diameter of the pores is 1-3 microns. The long-acting healing-promoting artificial skin disclosed by the invention has an excellent wound healing promoting effect, and a long-acting wound healing promoting effect is achieved by slowly releasing the degradable growth factor supported microspheres on the corium layer to the wounded part. Moreover, the corium layer degradation speed of the long-acting healing-promoting artificial skin can be well matched with the wound repair speed, so that the wound healing needs are well met.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a long-acting artificial skin for promoting healing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body and has the functions of retaining moisture in the body, preventing excessive heat dissipation, ventilating and preventing bacterial invasion. If only a superficial layer or a small area of ​​skin is damaged, new skin will regenerate itself, but if there is a severe trauma, the skin cannot repair itself, and the superficial skin or artificial skin from other parts of the body must usually be grafted to the wound superior. [0003] Most of the advanced artificial skin has epidermis and dermis. When it is implanted in the damaged area, the semi-permeable epidermis can protect, breathe and prevent bacterial invasion. The dermis has a three-dimensional porous scaffold structure. After a few weeks after the operat...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/22A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58A61L27/60
CPCA61L27/025A61L27/227A61L27/24A61L27/50A61L27/54A61L27/56A61L27/58A61L27/60A61L2300/414A61L2300/602A61L2300/622C08L89/00
Inventor 卢亢陈锦涛吴帅
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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