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Organic electrochemical transistor sensor based on molecularly imprinted membrane

A molecularly imprinted membrane and transistor technology, applied in the field of biochemical sensors, can solve problems such as limiting the application of organic electrochemical transistors, and achieve the effects of low detection limit, good selectivity and simple operation

Active Publication Date: 2017-05-31
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As a member of thin film transistors, organic electrochemical transistors not only have the performance of thin film transistors, but also have the characteristics of working at a voltage lower than 1V, good biocompatibility, use in solution, and simple preparation. When using it, it is necessary to add specific selective membranes or specific enzymes, which greatly limits the application of organic electrochemical transistors in biochemical sensing.

Method used

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  • Organic electrochemical transistor sensor based on molecularly imprinted membrane
  • Organic electrochemical transistor sensor based on molecularly imprinted membrane
  • Organic electrochemical transistor sensor based on molecularly imprinted membrane

Examples

Experimental program
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Embodiment 1

[0040] In this example, L-chromophore acid is used as a template molecule and o-phenylenediamine is used as a functional monomer to electropolymerize on the surface of a gold electrode to form a molecularly imprinted film, and the gold electrode modified with the L-chromophore acid molecularly imprinted film is used as The gate of the OECT sensor realizes the specific adsorption of L-tryptophan. The specific preparation method is as follows:

[0041] 1. Electrode pretreatment: Polish the gold electrode on the suede with 0.3 μm and 0.05 μm alumina powder in turn, then ultrasonically clean it with ultrapure water for 3 minutes; then soak the gold electrode in concentrated sulfuric acid (mass concentration: 98%) / hydrogen peroxide (mass concentration is 30%) (V / V=3:1) solution for 30min, after taking it out, then use ultrapure water to sonicate 3 times (1min / time), use N 2 blow dry. Finally, place the gold electrode in 0.5M H 2 SO 4 Activated in the solution, the potential win...

Embodiment 2

[0053] In this example, L-histidine is used as a template molecule and acrylamide is used as a functional monomer to electropolymerize on the surface of a gold electrode to form a molecularly imprinted membrane, and the gold electrode modified with the L-histidine molecularly imprinted membrane is used as an OECT sensor The gate realizes the specific adsorption of L-histidine. Its concrete preparation method is identical with embodiment 1, difference is:

[0054] In step 2, the polymerization solution contains L-histyl acid and acrylamide at concentrations of 20mM and 1M respectively, and contains initiator potassium persulfate (10mM), crosslinking agent N, N-dimethylene bisacrylamide (40mM) , the polymerization potential is -0.4~-1.4V, the polymerization rate is 20mV / s, and the number of polymerization circles is 20 circles. The eluent used in step 3 is 0.1M hydrochloric acid solution.

[0055] The current and impedance changes before and after polymerization, elution and a...

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Abstract

The invention discloses an organic electrochemical transistor sensor based on a molecular imprinted membrane, characterized in that a gate electrode of the organic electrochemical transistor sensor adopts a gold electrode modified with the molecular imprinted membrane, and the gate electrode is obtained by that an object to be detected is used as a template molecule, the template molecule is polymerized with a corresponding functional monomer by cyclic voltammetry to form a polymer membrane on the surface of the gold electrode firstly, and then the template molecule in the polymer template is eluted; and the gate electrode regulates and controls the channel current between a source electrode and a drain electrode through the solution of the object to be tested to constitute the organic electrochemical transistor sensor for selectively recognizing the object to be detected. The invention combines the molecular imprinting technique with the organic electrochemical transistor device, uses the specificity selection of the molecular imprinting technique and the signal amplification function of the organic electrochemical transistor sensor to recognize the specificity of the object to be detected, can selectively absorb the micro and even trace object to be detected, and has good selectivity, high sensitivity and low detection limit.

Description

technical field [0001] The invention relates to a sensor capable of identifying and separating objects to be detected, belonging to the field of biochemical sensors. Background technique [0002] As a member of thin film transistors, organic electrochemical transistors not only have the performance of thin film transistors, but also have the characteristics of working at a voltage lower than 1V, good biocompatibility, use in solution, and simple preparation. When used, additional specific selective membranes or specific enzymes need to be added, which greatly limits the application of organic electrochemical transistors in biochemical sensing. [0003] Molecular imprinting technology (MIT) uses the target to be detected as a template molecule, and polymerizes with the corresponding functional monomer under the action of light, heat, electricity, catalyst, initiator, etc., to form Exactly matching polymer approach. When the template molecule (imprinted molecule) contacts wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/327
Inventor 邱龙臻张利君吴迪
Owner HEFEI UNIV OF TECH
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