A phenanthroindolizidine alkaloid and a preparing method thereof

A technology of phenanthrene indolizidine and alkaloid, which is applied in the field of phenanthrene indolizidine alkaloid and its preparation, can solve the problem of no inhibitory effect and the like, and achieves strong antibacterial activity and consistent component types. Effect

Inactive Publication Date: 2017-06-20
JIANGXI AGRICULTURAL UNIVERSITY
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the inhibitory effect of phenanthrene indolizidine alkaloids on Penicillium italicum

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A phenanthroindolizidine alkaloid and a preparing method thereof
  • A phenanthroindolizidine alkaloid and a preparing method thereof
  • A phenanthroindolizidine alkaloid and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] 1) Take Baiwei medicinal material, grind it, and extract it with a solvent 10-50 times the weight of the medicinal material, the solvent is 5-100% ethanol aqueous solution, 5-100% methanol aqueous solution, chloroform, dichloromethane, ethyl acetate or acetone, extract The method is extraction by soaking, heating under reflux, ultrasonic-assisted extraction, microwave-assisted extraction or supercritical carbon dioxide extraction, the extraction time is 10-150 minutes, the extraction is 1-4 times, the combined extracts are filtered, the solvent is concentrated under reduced pressure and the solvent is recovered to obtain the Bai Wei extract;

[0034] 2) Suspend the Baiwei extract in step 1) in distilled water of 8 to 15 times the weight of the Baiwei extract, extract three times with an equal volume of n-butanol solvent, combine the n-butanol extracts and concentrate under reduced pressure to recover the solvent. Debai Wei n-butanol extract;

[0035]3) Suspend the Baiwe...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A phenanthroindolizidine alkaloid, and a preparing method and applications thereof are disclosed. Blackend swallowwort root which is a Chinese herbal medicine is adopted as a raw material and is extracted with a solvent; and after an extract is extracted with an n-butanol solvent, an obtained extract is separated by macroporous resin column chromatography, silica gel column chromatography, ODS-C<18> reverse silica gel column chromatography, Sephadex LH-20 gel column chromatography and preparative high performance liquid chromatography in order to obtain one high-purity phenanthroindolizidine alkaloid, with the purity of the phenanthroindolizidine alkaloid obtained being 98.5%. The alkaloid is identified as 7-demethoxytylophorine. The obtained alkaloid is subjected to bacteriostatic activity research on penicillium italicum, and the 7-demethoxytylophorine has good bacteriostatic effects on the penicillium italicum and can be developed into a novel plant-sourced citrus preservative.

Description

technical field [0001] The invention relates to the fields of fruit disease prevention and fresh-keeping, in particular to a phenanthrene-indolizidine alkaloid capable of inhibiting postharvest pathogens of citrus and a preparation method thereof. Background technique [0002] Cynanchum atratum is the dry root and rhizome of Cynanchum atratum, a plant of the genus Cynanchum atratum in the family Rumoaceae, and it is a commonly used traditional Chinese medicine for clearing deficiency and heat, and it is recorded in many ancient books of traditional Chinese medicine. According to the "Dictionary of Traditional Chinese Medicine", Baiwei is cold in nature, bitter in taste, and salty. Fever, postpartum blood deficiency fever, hot stranguria, stranguria with blood, carbuncle and swelling. Studies on chemical composition and pharmacological activity have shown that Baiwei mainly contains C 21 Steroidal saponins, cardiac glycosides, astragalus, volatile oil and other ingredients ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04A01N43/90A01P3/00A23B7/154
CPCA01N43/90A23B7/154C07D471/04Y02P20/54
Inventor 万春鹏陈金印陈楚英陈明
Owner JIANGXI AGRICULTURAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap