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Self-destruction block polymer and preparation method thereof

A technology of block polymer and diblock polymer is applied in the field of self-destruction block polymer and its preparation, and achieves the effects of simple synthesis process, mild reaction conditions and strong controllability

Active Publication Date: 2017-06-20
SHANGHAI UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to design a novel self-destructible redox-responsive polymer nanocarrier to make up for the defects of pure redox nanocarriers

Method used

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  • Self-destruction block polymer and preparation method thereof
  • Self-destruction block polymer and preparation method thereof

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Embodiment

[0039] Embodiment: the process and steps in this embodiment are as follows:

[0040] 1. Preparation of self-destructive triblock polymer PEG-PCN-PEG

[0041] Weigh 1.0g of 2,2′-dithiodiethanol bis(p-nitrophenyl carbonate) (abbreviated as DTDE-PNC) (2.070mmol), put it into a round bottom flask, add 2mL of dichloro The mixed solution of methane and methanol (volume ratio is 9:1), under the protection of nitrogen, add the rotor and stir until the compound is completely dissolved; weigh 664.9mg of methoxy polyethylene glycol amine (0.129mmolmPEG-NH 2 ) was dissolved in 2 mL of a mixture of dichloromethane and methanol (volume ratio of 9:1), added dropwise to the above-mentioned flask, and stirred at room temperature for 2 hours under nitrogen protection; weighed 434.8 mg of 1,3-bis(4 -piperidinyl)propane (2.005mmol) was dissolved in 200μL of the mixed solution (the volume ratio of dichloromethane to methanol was 9:1), and reacted at room temperature under nitrogen protection for ...

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Abstract

The invention relates to a self-destruction block polymer and a preparation method thereof. A structural formula of a three-block polymer PEG-PCN-PEG (as an example, detailedly introduced by the invention) is shown as the accompanying drawing; a structural formula of a two-blockpolymer PEG-PCN (synthesis and expression methods are the same as those of the three-block polymer) is shown as the accompanying drawing. The preparation method has the advantages that the process is simple; the self-destruction block polymer can be prepared by a one-pot method and has the characteristics that the reaction conditions are mild; the controllability is high, and the like. The obtained novel self-destruction block polymer can realize self-assembly in a water solution to form hydrophilic outer shell-hydrophobic inner shell spherical micelles; the polymer micelles can completely crack into small molecule compounds through self-destruction under the simulation of oxidization and reduction; the biodegradable performance of materials can be improved.

Description

technical field [0001] The invention relates to a self-destruction block polymer and a preparation method thereof, belonging to the technical field of polymer chemical synthesis and block polymer self-assembly. Background technique [0002] Effective delivery and uptake of chemotherapeutic drugs is the key to overcoming drug resistance of tumors and improving the efficacy of chemotherapy. Polymers have potential application prospects as drug carriers, but necessary chemical modifications are required to realize their multifunctionality. In addition, in order to be applied in vivo or even clinical research, the in vivo stability and effective controllable release of the carrier must be taken into account. The redox-responsive polymer nanocarrier delivery system has always been the research focus of nanocarriers in the field of cancer therapy, but there are still some problems, such as incomplete breakage of the polymer backbone and incomplete release of entrapped drugs. In a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G64/42C08G64/30A61K47/34
CPCA61K47/34C08G64/30C08G64/42C08G81/00
Inventor 金荣郑新涛曹傲能郭雪连
Owner SHANGHAI UNIV
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