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Denture base for preventing denture stomatitis

A technology for denture base and stomatitis, which is applied in the field of denture base for preventing and treating denture stomatitis, can solve the problems of side effects of surrounding tissues, limit antibacterial activity, affect the mechanical properties of carrier materials, etc. effect of stomatitis

Active Publication Date: 2019-12-31
中国人民解放军联勤保障部队第九二〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the two types of materials have their own advantages and disadvantages in terms of antibacterial timeliness, antibacterial efficiency, and influence on carrier materials. How to develop organic-inorganic composite antibacterial materials that have both advantages has gradually become a focus of attention of scholars.
Adding silver nanoparticles alone has no chemical connection with the resin matrix, and is simply dispersed in the resin matrix. Therefore, the release rate is difficult to control, and the antibacterial activity decreases over time.
At the same time, the release of antibacterial components will affect the mechanical properties of the carrier material and cause a series of side effects on the surrounding tissues
The quaternary ammonium salt monomer can undergo polymerization reaction with the resin matrix components to form a chemical bond, but it is not easy to release and has stable chemical properties. Adding an appropriate amount to the resin will not affect the mechanical properties of the carrier material, but the limited amount of addition limits the Its antibacterial activity, and the addition of too much will lead to a series of problems such as unstable chemical combination, affecting the overall performance and stability of the carrier material

Method used

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  • Denture base for preventing denture stomatitis
  • Denture base for preventing denture stomatitis
  • Denture base for preventing denture stomatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Synthesis and Characterization of 1AgBr / NPVP

[0035] The raw materials required for the synthesis experiment are polyvinylpyridine, silver p-toluenesulfonate, nitromethane, 1-bromohexane, diethyl ether and dimethyl sulfoxide.

[0036]The method for synthesizing AgBr / NPVP is as follows: Dissolve poly-4-vinylpyridine [poly(4-vinylpyridine), PVP] (2.1g, 20mmol) and 0.3 equivalent of 1-bromohexane (0.85mL, 6mmol) in 25ml Nitromethane was stirred in a 60°C water bath for 24h to obtain a pale yellow product NPVP. Subsequently, an excess of silver paratoluenesulfonate solution (AgPTS) was slowly added to the polymer, and through this in-situ precipitation method, it was mixed to finally obtain a quaternary ammonium salt polymer-wrapped silver bromide nanocomposite (AgBr / NPVP ),See figure 1 with figure 2 . figure 2 Among them, n represents the degree of polymerization of poly-4-vinylpyridine, x represents the grafting amount of 1-bromohexane, and the value of x has litt...

Embodiment 2

[0082] 1 Materials and methods

[0083] 1.1 Main materials, reagents and instruments: silver bromide nanocomposite coated with quaternary ammonium salt, Streptococcus mutans UA159, brain heart extract broth, artificial saliva, live / dead bacteria staining kit, Bis-GMA, TEGDMA, camphorquinone, Dimethylaminoethyl methacrylate, ultra-clean bench, anaerobic culture tank, Vitek bacterial turbidimeter, vortex mixer, micro-sampler, 24-well cell culture plate, laser confocal microscope, universal testing machine, dimension Hardness tester.

[0084] 1.2 Experimental method

[0085] 1.2.1 Synthesis of quaternary ammonium salt-wrapped silver bromide nanocomposites First, bromohexane and methyl 2-bromoethylacrylate were grafted onto poly-4-vinylpyridine [poly(4-vinylpyridine) by quaternization reaction. , PVP] on the side chain, nitromethane as a solvent, stirred in a water bath at 60°C for 24h, and synthesized quaternary ammonium methacrylates (quaternary ammoniummethacrylates, BHPVP). ...

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Abstract

The invention discloses a false-tooth base for preventing and treating denture stomatitis. The false-tooth base is prepared through adding a quaternary ammonium salt coated silver bromide composite into denture acrylic, so as to prevent and treat the denture stomatitis. The quaternary ammonium salt coated silver bromide composite is prepared through grafting a grafted monomer to a lateral chain of poly(4-vinylpyridine) through quaterisation so as to obtain a polymer, then, slowly adding silver paratoluenesulfonate into the polymer, and carrying out an in-situ precipitation method. The grafted monomer is bromohexane and / or 2-bromoethylmethyl acrylate. The false-tooth base disclosed by the invention is prepared through adding the quaternary ammonium salt coated silver bromide nanocomposite into the denture acrylic, is endowed with durable and stable antibacterial performance and is particularly applicable to the inhibition of Candida albicans.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of common oral diseases, and mainly relates to a denture base used for prevention and treatment of denture stomatitis. Background technique [0002] Full mouth and removable partial dentures are widely used as traditional restoration methods in oral clinic. The disadvantage is that they are easy to cause some oral diseases, especially in elderly patients. Denture stomatitis occurs in about 70% of patients who wear dentures, most of which are related to Candida albicans. Factors such as easy adhesion of microorganisms and biofilms, rough and hydrophobic denture surfaces, and resistance of Candida albicans to conventional antibacterial agents have made denture stomatitis one of the difficulties in oral treatment. For this reason, the most effective way to prevent denture stomatitis is the use of denture base resins with properties that inhibit Candida albicans biofilm formation. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/02A61K6/083A61C13/01
CPCA61C13/01A61K6/80A61K6/887C08L39/08C08L51/003
Inventor 肖玉鸿邢晓东陈吉华张瑜曹巍巍陈银燕胡运通
Owner 中国人民解放军联勤保障部队第九二〇医院