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Application of NADPH (nicotinamide adenine dinucleotide phosphate) in preparation of medicine for treating cardiac hypertrophy and cardiac failure

A technology for myocardial hypertrophy and heart failure, applied in drug combinations, pharmaceutical formulas, cardiovascular system diseases, etc., can solve problems such as increased arrhythmia, many adverse reactions, and general curative effect in the decompensated period, achieving cardiotonic effect and significant The effect of action

Inactive Publication Date: 2017-06-30
CHONGQING NADPH IND GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned (1)-(4) drugs relieve or reverse myocardial hypertrophy, gradually improve cardiac function, and are suitable for long-term treatment of myocardial hypertrophy or chronic heart failure. The curative effect of the decompensated phase of the drug is average, and it cannot be used for the treatment of acute heart failure; and the (5) category of drugs has many and serious adverse reactions in clinical application, such as: increasing the risk of arrhythmia, and even increasing the risk of heart failure. mortality rate
[0006] At present, there is no report on the use of NADPH in the treatment of myocardial hypertrophy and heart failure

Method used

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  • Application of NADPH (nicotinamide adenine dinucleotide phosphate) in preparation of medicine for treating cardiac hypertrophy and cardiac failure
  • Application of NADPH (nicotinamide adenine dinucleotide phosphate) in preparation of medicine for treating cardiac hypertrophy and cardiac failure
  • Application of NADPH (nicotinamide adenine dinucleotide phosphate) in preparation of medicine for treating cardiac hypertrophy and cardiac failure

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental example 1 The Experiment of Cardiotonic Effect of NADPH on Frog Heart in Vitro

[0029] (1) Experimental materials

[0030] Toad (60-80g) was provided by the Experimental Animal Center of Soochow University School of Medicine, experimental animal use license number: SYXK (Su) 2002-0037;

[0031] Animal breeding environment: room temperature 22°C, humidity 50-60%, well ventilated, artificial day and night (12h / 12h), free intake of food and water;

[0032] The source of exogenous NADPH drugs can be obtained through artificial synthesis, semi-synthesis, and biological extraction;

[0033] (2) Experimental method

[0034] The toads were demyelinated and fixed on the frog plate, the left and right aortas and inferior vena cava were separated, the inferior vena cava was inserted into the venous cannula, the left aorta was inserted into the arterial cannula, the right aorta was ligated, and Ren's solution (1000mL: NaCl 6.5g , KCl 0.14g, CaCl 2 0.12g, NaHCO ...

experiment example 2

[0040] Experimental example 2 Mouse model of cardiac hypertrophy

[0041] (1) Experimental materials

[0042] SPF grade ICR mice (male, weighing 18-22g) were provided by the Experimental Animal Center of Soochow University School of Medicine, experimental animal production license number: XCYK (Su) 2002-2009;

[0043] Animal breeding environment: room temperature 22°C, humidity 50-60%, well ventilated, artificial day and night (12h / 12h), free intake of food and water;

[0044] The source of exogenous NADPH drugs can be obtained through artificial synthesis, semi-synthesis, and biological extraction;

[0045] ATPase kit (A070-6), purchased from Nanjing Jiancheng Bioengineering Institute;

[0046] Isoproterenol (ISO) and captopril (Cap) were purchased from Shanghai Macklin Biochemical Technology Co., Ltd.;

[0047] Chloral hydrate was purchased from Sinopharm Chemical Reagent Co., Ltd.;

[0048] Electrocardiograph (Kenz, ECG-103).

[0049] (2) Experimental method

[0050...

experiment example 3

[0079] Experimental example 3 Effect of NADPH on Blood Pressure of Normal Rats

[0080] (1) Experimental materials

[0081] SD rats (male, weighing 250-300 g) were provided by the Experimental Animal Center of Soochow University School of Medicine;

[0082] Animal breeding environment: room temperature 22°C, humidity 50-60%, well ventilated, artificial day and night (12h / 12h), free intake of food and water;

[0083] Non-invasive blood pressure detection system (Kent Scientific, CODA20496).

[0084] (2) Experimental method

[0085] Non-invasive measurement of tail artery blood pressure in rats: use volume pressure recording sensor to non-invasively measure the blood pressure of conscious rats. The rats are fed normally for 2 days, and the blood pressure of the rats is measured with a non-invasive blood pressure detection system. The experimental environment is controlled in a quiet and constant temperature, and the adaptive training starts after 3 days formal experiment. ...

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Abstract

The invention belongs to the field of medicines, and particularly relates to application of NADPH (nicotinamide adenine dinucleotide phosphate) in preparation of a medicine for treating cardiac hypertrophy and cardiac failure. A research shows that the NADPH has an outstanding cardiotonic effect and also has an effect of relieving the cardiac hypertrophy, so that the NADPH can be used as a medicine for treating the cardiac hypertrophy and the cardiac failure. A further research shows that the NADPH can improve the activity of Na<+>-K<+>-ATP enzyme, Ca<2+>-Mg<2+>-ATP enzyme and total ATP enzyme in the cardiac muscle tissue of a mouse, thus speculating that the NADPH may achieve a relieve effect on the cardiac failure and the cardiac hypertrophy through the mechanism; meanwhile, the NADPH has no obvious influence on the blood pressure of a normal rat and is relatively low in adverse effect during treatment of the cardiac hypertrophy and the cardiac failure.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application of NADPH in the preparation of medicines for treating myocardial hypertrophy and heart failure. Background technique [0002] Reduced nicotinamide adenine dinucleotide phosphate (triphosphopyridine nucleotide, NADPH) is produced by the metabolism of glucose through the pentose phosphate pathway (PPP). Biosynthesis provides hydrogen ions. NADPH is the coenzyme of glutathione (GSH) reductase, which can generate reduced GSH from oxidized glutathione (GSSG) and maintain the normal content of reduced GSH. GSH is an important antioxidant in cells, which can protect some sulfhydryl-containing proteins, fats and proteases from the damage of oxidants, especially playing an important role in maintaining the integrity of red blood cell membranes. In addition to participating in the biosynthesis of cholesterol, fatty acids, monooxygenases, steroid hormones, etc., NADPH ...

Claims

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Application Information

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IPC IPC(8): A61K31/7084A61P9/04A61P9/00
CPCA61K31/7084
Inventor 秦正红盛瑞凌月娟朱路佳
Owner CHONGQING NADPH IND GRP CO LTD
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