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Method for preparing antibacterial surface on medical material surface

An antibacterial agent and surface modification technology, which is applied in the field of preparation of antibacterial surfaces, can solve problems such as performance mutual interference, anti-adhesion ability and bactericidal ability affecting surface antibacterial ability, and instability of polypeptide antibacterial agents, so as to reduce adverse effects and achieve excellent results. Long-term antibacterial performance, avoiding the effect of mutual interference of performance

Active Publication Date: 2017-06-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the anti-adhesion polymer layer and antibacterial agent introduced on the surface of medical materials in the prior art, but the anti-adhesion ability and bactericidal ability interact to affect the antibacterial ability of the surface, and the instability of the polypeptide antibacterial agent itself, this paper The purpose of the invention is to provide a method for preparing an antibacterial surface on the surface of medical materials, which avoids the mutual interference of performance, and improves the problem that antibacterial agents are degraded by enzymes in vivo, and obtains more excellent long-term antibacterial performance

Method used

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  • Method for preparing antibacterial surface on medical material surface
  • Method for preparing antibacterial surface on medical material surface
  • Method for preparing antibacterial surface on medical material surface

Examples

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Effect test

Embodiment 1

[0051] Such as figure 1 As shown, the method for preparing an antibacterial surface on the silicon wafer surface of the present embodiment may further comprise the steps:

[0052] (1) Perform oxygen plasma pretreatment on the surface of the silicon substrate, the working parameters are power 100W, pressure 20Pa, gas flow rate 300ml / min, temperature 30°C, time 5min; the pretreated silicon substrate is immersed in 3-aminopropyltri In the ethanol solution of ethoxysilane, aminosilane is chemically grafted on the surface of the silicon substrate, the reaction temperature is 30°C, and the time is 5h; wherein, the volume concentration of 3-aminopropyltriethoxysilane is 2%.

[0053] (2) Immerse the silicon substrate grafted with aminosilane on the surface in the dichloromethane solution of the acyl compound, and react with the acyl compound at a temperature of 20°C for 3 hours to prepare a silicon substrate with an atom transfer radical polymerization initiator modified surface Surf...

Embodiment 2

[0067] The method for preparing an antibacterial surface on the medical titanium surface of the present embodiment comprises the following steps:

[0068] (1) Perform oxygen plasma pretreatment on the surface of medical titanium, the working parameters are power 50W, pressure 30Pa, gas flow rate 30ml / min, temperature 30°C, time 3min; immerse the pretreated medical titanium surface in 3-aminopropyl In the ethanol solution of triethoxysilane, the reaction conditions for grafting aminosilane on the surface of medical titanium are as follows: 3-aminopropyltriethoxysilane volume concentration is 8%, temperature is 25°C, and time is 1h.

[0069] (2) Immerse the medical titanium on the surface of the grafted aminosilane in the dichloromethane solution of the acyl compound, and react with the acyl compound to obtain the silicon substrate surface of the initiator modified surface of the atom transfer radical polymerization; the reaction conditions are: The volume concentration of 2-bro...

Embodiment 3

[0074] The method for preparing an antibacterial surface on the medical titanium surface of the present embodiment comprises the following steps:

[0075] (1) Perform oxygen plasma pretreatment on the surface of medical titanium, the working parameters are power 400W, pressure 60Pa, gas flow rate 250ml / min, temperature 30°C, time 10min; immerse the pretreated medical titanium surface in 3-aminopropyl In the ethanol solution of triethoxysilane, aminosilane is grafted on the surface of medical titanium, the reaction conditions are: the volume concentration of 3-aminopropyltriethoxysilane is 8%, the temperature is 25°C, and the time is 0.5h.

[0076] (2) Immerse the medical titanium grafted with aminosilane on the surface in the solution of the acyl compound, and react with the acyl compound to prepare the surface of the silicon substrate modified by the atom transfer radical polymerization initiator; the reaction conditions are: 2-bromoisobutyl The volume concentration of acid b...

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Abstract

The invention discloses a method for preparing antibacterial surface on medical material surface. The method comprises the following steps: (1) conducting chemical grafting of amino silane after performing oxygen plasma pretreatment to the medical material surface and then reacting the medical material of the amino silane grafted surface with an acyl compound; (2) placing the medical material of an initiator modified surface into an anti-adhesion water solution for graft polymerization reaction; (3) placing the medical material of an anti-adhesion polymer brush-modified surface into an azide compound-containing dimethylformamide solution; and (4) placing the medical material of the azide surface into an antibacterial agent click solution for click reaction, to obtain anti-adhesion polymer surface and antibacterial agent-comodified antibacterial surface. According to the method, the mutual interference of the anti-ahdesion capability and sterilization capability can be avoided, the antibacterial surface has excellent long-acting antibacterial performance, the adverse effect of the sterilized surface on blood and somatic cells can be reduced, and the biocompatibility is excellent.

Description

technical field [0001] The invention relates to medical materials, in particular to a method for preparing an antibacterial surface on the surface of medical materials. Background technique [0002] Our health is threatened by some microorganisms, and antibacterial materials have become very important in our daily life. With the improvement of social health awareness, the application of implant materials is becoming more and more extensive, and the problem of implant infection caused by bacteria has also attracted more and more attention. Although the aseptic treatment of materials and the use of preoperative antibiotics can reduce the occurrence of such infections to a certain extent, 4% to 6% of patients still have implant failure due to bacterial infection at the initial stage of implantation, which brings great harm to patients. Great pain and financial burden. In China, the clinical incidence of this type of infection is as high as 15%. Therefore, implant materials n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/14A61L31/10C08F292/00
CPCA61L31/10A61L31/14A61L31/16C08F292/00A61L2400/18A61L2300/252A61L2300/404C08F2438/01C08L51/10A61L2300/25A61L2300/102A61L27/54A61L27/50A61L27/34C08F220/38C04B41/4533C23C16/45536
Inventor 任力王琳何精才王迎军
Owner SOUTH CHINA UNIV OF TECH
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