A kind of α-lipoic acid molecularly imprinted polymer and its preparation method
A molecularly imprinted and lipoic acid technology, applied in the field of alpha-lipoic acid molecularly imprinted polymer and its preparation, can solve the problems of lack of controllability of alpha-lipoic acid release behavior, achieve good temperature sensitivity and sustained release performance, and improve stability sexual effect
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[0026] The present invention also provides a method for preparing the α-lipoic acid molecularly imprinted polymer described in the above technical solution, comprising the following steps:
[0027] (1) mixing α-lipoic acid, N-isopropylacrylamide, porogen, crosslinking agent and initiator to obtain a mixed solution;
[0028] (2) After the mixed solution obtained in the step (1) is deoxidized, the α-lipoic acid molecularly imprinted polymer is obtained through cross-linking polymerization.
[0029] The invention mixes alpha-lipoic acid, N-isopropylacrylamide, porogen, cross-linking agent and initiator to obtain a mixed solution. In the present invention, the molar ratio of the alpha-lipoic acid (ALA) to N-isopropylacrylamide (NIPAM) is preferably 1:1 to 3, more preferably 1:1.5 to 2.5, most preferably 1: 2. In the present invention, the molar ratio of the N-isopropylacrylamide to the crosslinking agent is preferably 1:2.5-5, more preferably 1:3-4.5, and most preferably 3.5-4. ...
Embodiment 1
[0045] The molar ratio of template molecules to functional monomers is 1:1: weigh 1.04g ALA, 0.57g NIPAM, 0.10g AIBN in a conical flask, add 20mL of acetonitrile to dissolve, add 10g of EGDMA to mix, ultrasonic degassing for 5min, and fill the conical flask with nitrogen for 5min , repeated ultrasonication-nitrogen immersion twice, then plugged and sealed, placed in a 60°C water bath for 3 hours, and the obtained white solid polymer was ground and passed through a 200-mesh (75μm) sieve, and unreacted monomers and other components were removed with n-hexane. After washing with hot water at 50°C, the prepared polymer was dried at 50°C for 24 hours to obtain α-lipoic acid molecularly imprinted polymers (ALA-MIPs).
[0046] The ALA content in the ALA-MIPs prepared in this example was 13.68 mg / g, and the yield was 32.53%.
Embodiment 2
[0065] The molar ratio of template molecules to functional monomers is 1:2: weigh 0.52g ALA, 0.57g NIPAM, and 0.10g AIBN in a Erlenmeyer flask, add 20mL of acetonitrile to dissolve, add 10g of EGDMA to mix, ultrasonically defoam for 5min, and fill the Erlenmeyer flask with nitrogen for 5min , repeated ultrasonication-nitrogen immersion twice, then plugged and sealed, placed in a 70°C water bath for 5 hours, and the obtained white solid polymer was ground and passed through a 200-mesh (75μm) sieve, and the unreacted monomer and the rest were removed with n-hexane After washing with hot water at 50°C, the prepared polymer was dried at 50°C for 24 hours to obtain α-lipoic acid molecularly imprinted polymers (ALA-MIPs).
[0066] The ALA content in the obtained ALA-MIPs was 14.44mg / g, and the yield was 57.34%. ALA starts to be released when the temperature is lower than 22°C, and the release conforms to the first-order kinetic release behavior, that is, the release behavior belongs...
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