Preparation method of alogliptin benzoate tablet high in bioavailability
A technology of alogliptin tablets and benzoic acid, which is applied in the field of preparation of alogliptin benzoate tablets, can solve the problems of affecting human absorption, slow disintegration, and lowering the level of hemoglobin Alc, so as to speed up the disintegration speed and speed up Absorption, bioavailability enhancement effect
Inactive Publication Date: 2017-07-04
CISEN PHARMA
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The invention belongs to the technical field of drug preparation, and more specifically relates to a preparation method of alogliptin benzoate tablet high in bioavailability. The preparation method comprises following steps: alogliptin benzoate raw material is subjected to micronization treatment; prescription dosages of alogliptin benzoate, a filling material, and a disintegrating agent are weighed, and are uniformly mixed, a prescription dosage of an adhesive solution is added so as to obtain a soft material, the soft material is sieved using a sieve of 20 meshes, and is subjected to drying and size stabilization, and a prescription dosage of a lubricant is added for uniform mixing so as to obtain mixed particles; the mixed particles are subjected to tabletting using a tablet machine; and coating is carried out so as to obtain finished products. Compared with the prior art, the preparation method comprises following advantages: raw material micronization is adopted so as to increase disintegrating speed; and the particle size is reduced, so that absorption by human body is accelerated, and the bioavailability of alogliptin benzoate is increased.
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Property | Measurement | Unit |
Particle size | 110.0 ~ 120.0 | µm |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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