Application of Taurine Chelated Calcium in Preparation of Transdermal Absorption Preparation

Abstract

The invention relates to the application of taurine chelated calcium in the preparation of percutaneous absorption preparations. The method of percutaneous absorption and calcium supplementation can give priority to supplementing the physiologically active ionic calcium required by the body to the greatest extent, especially this kind of ionic calcium that can be absorbed through the skin. The method of calcium supplementation can directly and quickly realize the supplementation of calcium to the epidermal system without blood circulation system, and solve the problem that the oral calcium supplement is first used for bone formation and becomes non-physiologically active. The problem of calcium deficiency, at the same time, taurine has the function of regulating the concentration of calcium ions inside and outside the cells of the body, that is, it inhibits the concentration of calcium ions at high concentrations, and promotes it at low concentrations, which can adjust the problems of calcium deficiency and excess calcium in skin cells. An important adjustment method of internal and external calcium ion balance, the role of taurine chelated calcium that can be absorbed through the skin in the present invention can be used in the preparation of external pharmaceutical preparations, medical and sanitary materials, external health care preparations, and cosmetics.

Description

technical field [0001] The invention relates to a kind of taurine chelated calcium for percutaneous absorption and treatment of skin diseases or systemic calcium supplementation, which has excellent transdermal absorption effect and can quickly transdermally supplement calcium ions and taurine required by the skin. It has the function of regulating the concentration of calcium ions inside and outside the epidermal cells of the body and repairing the skin barrier function. At the same time, because its stability in aqueous solution is far superior to the characteristics of other protein amino acids, it is more suitable for the preparation of aqueous external preparations, such as smears, creams, liniments, sprays, gels, etc. . It is especially suitable for preparing pharmaceutical external preparations, medical and health preparations, health care external preparations, and cosmetics, and can be used for treating various skin diseases caused by skin calcium deficiency, repairi...

AI Technical Summary

Problems solved by technology

[0006] When the human body is in a state of calcium deficiency, the calcium supplemented by oral supplementation is preferentially used to supplement the combined calcium required by bones and teeth. At this time, the supplemented calcium has lost its physiological activity and cannot be supplemented or can only be supplemented in a very small amount. Ionized calcium, but this is insufficient for regulating the physiological activity of the body, so it is very difficult to maintain the balance and stability of the epidermal calcium ion by transporting calcium ions to the epidermis through blood circulation in the case of calcium deficiency in the human body

[0007] Oral calcium preparations are difficult to absorb, have a low absorption rate, and are affected by many and complicated factors, which are mainly caused by the complex environment of the gastrointestinal tract

Oral supplemented calcium is digested and absorbed through the gastrointestinal tract. The environment of the stomach is a strongly acidic environment with a pH value varying between 0.8 and 3.6. The environment of the small intestine is weakly alkaline and the pH value varies between 7.2 and 8.0. This change in the acid-base environment is unfavorable for the absorption of calcium ions. For example, calcium ions tend to form gelatinous calcium hydroxide precipitates in the alkaline intestinal environment, making it difficult for calcium ions to be absorbed by the body. At the same time, this gelatinous Thick matter can adhere to the intestinal wall, further affecting the absorption of other nutrients

In particular, oral calcium is easily polluted by anions in the gastrointestinal tract to form insoluble calcium, resulting in a significant reduction in the absorption rate of calcium ions, such as phytic acid, oxalic acid, alkaline phosphate, fat, and dietary fiber contained in the ingested food. Uronic acid residues, nucleotides, uric acid, etc. can react with calcium ions to form insoluble or insoluble calcium oxalate, calcium phytate, basic calcium phosphate, calcium urate, etc., which not only interfere with the absorption of calcium ions, but also Causing calcium to precipitate in tissues to become calcification foci, and to form stones in organs, affecting health

[0008] 2. There is no blood circulation system in the human epidermal system, and it is difficult to transport calcium ions with physiological activity.

[0010] 3. There is currently a lack of targeted calcium supplements for external use on the market

[0011] All kinds of calcium supplements currently on the market are oral preparations, including various calcium tablets and oral liquids, which are mainly developed for the special digestive system of the gastrointestinal tract. The pH value of the gastrointestinal tract is between 0.8 and 3.6. It belongs to a strong acid environment, and there are also various fungi, organic acids, and anions that pollute calcium ions and become insoluble substances that cannot be absorbed by the human body. The normal pH value of the human epidermis is between 5.2 and 6.5, which belongs to a weakly acidic environment. , so oral calcium preparations generally used for digestion and absorption through the gastrointestinal tract are difficult to absorb through the skin

At the same time, the general oral calcium preparations mostly use inorganic calcium and ionic organic acid calcium such as calcium chloride, calcium carbonate, calcium lactate, calcium propionate, calcium citrate, calcium gluconate, etc. These calcium preparations are all in ionic state, and at the same time Some calcium salts also have the problem of poor solubility. In the field of percutaneous absorption, insoluble compounds and ionic compounds are very difficult to absorb

[0012] At the same time, no scholars have studied the problem of percutaneous absorption of calcium, so it is very necessary to study calcium supplements that are conducive to percutaneous absorption, and it is also a very innovative research topic. The body supplements with physiologically active ionic calcium, especially the targeted calcium supplementation to the epidermis system that does not exist in the blood circulation system, and has high absorption efficiency, and is not affected by the special and complex environment of the gastrointestinal tract. The ions are easily polluted by anions, which leads to the problem of low absorption and utilization

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