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Preparation method of gamma-Fe2O3 superparamagnetic nanoclusters

A superparamagnetic and nano-cluster technology, applied in the direction of nanotechnology, nanotechnology, medical preparations of non-active ingredients, etc., can solve the problems of difficult control of particle aggregation, easy particle agglomeration, high processing temperature, etc., and achieve a high success rate , good repeatability and high purity

Inactive Publication Date: 2017-07-21
SOUTHWEAT UNIV OF SCI & TECH
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AI Technical Summary

Problems solved by technology

Nano γ-Fe 2 o 3 Problems such as high processing temperature, easy agglomeration of particles, and difficulty in dispersing in the preparation process of the sci-tech workers have always been difficult problems faced by scientific and technological workers.
In order to improve the shortcomings of the existing technology in the preparation of magnetic colloidal particles, the particle aggregation is not easy to control, and to better control the γ-Fe 2 o 3 Aggregation of superparamagnetic colloidal particles, γ-Fe with anions 2 o 3 A hybrid scheme of nanoparticles and cationic neutral block copolymers is proposed

Method used

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  • Preparation method of gamma-Fe2O3 superparamagnetic nanoclusters
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  • Preparation method of gamma-Fe2O3 superparamagnetic nanoclusters

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preparation example Construction

[0044] γ-Fe of the present invention 2 o 3 A method for preparing a superparamagnetic nanocluster specifically comprises the following steps:

[0045] Step (1), prepare gamma-Fe 2 o 3 Superparamagnetic nanoparticles, the specific method is as follows:

[0046] (1.1), the FeCl 2 .4H 2 O dissolved in hydrochloric acid solution, the FeCl 3 .6H 2 O was dissolved in distilled water, and the dissolved FeCl 3 .6H 2 O solution added FeCl 2 .4H 2 After mixing evenly in the O solution, quickly add ammonia water and continue stirring for 15-30 minutes; where FeCl 2 .4H 2 O and FeCl 3 .6H 2 The mass ratio of O is 1~0.5~1:2, the mass concentration of hydrochloric acid solution is 0.05~0.1g / mL, FeCl 3 .6H 2 O solution and FeCl 2 .4H 2 The volume ratio of the sum of the mixed solution volumes of the O solution to the ammonia water added is 1-2:1.

[0047] (1.2), the stirred solution is placed in a gradient magnetic field, the solution is layered, the supernatant is removed...

Embodiment 1

[0062] First take 20g FeCl 2 .4H 2 O was dissolved in 60mL hydrochloric acid solution (50ml distilled water was diluted with 10ml concentrated hydrochloric acid solution), 20g FeCl 3 .6H 2 O was dissolved in 70mL distilled water; at a stirring speed of 100r / min, the dissolved FeCl 3 .6H 2 O solution added FeCl 2 .4H 2 After mixing evenly in the O solution, quickly add 100mL of ammonia water and continue to stir for 20min; place the stirred solution in a gradient magnetic field, the solution is clearly stratified, remove the supernatant, and wash the Fe with distilled water repeatedly. 3 o 4 magnetic particles; later in Fe 3 o 4 Add 40mL of concentrated nitric acid to the magnetic particles, slowly add 200mL of distilled water under magnetic stirring, and continue stirring for 50min. 3 o 4 The magnetic particle solution is placed in a gradient magnetic field, the supernatant is removed, and the ferric nitrate solution (40g Fe(NO 3 ) 3 .9H 2 O was dissolved in 80mL ...

Embodiment 2

[0070] First take 20g FeCl 2 .4H 2 O was dissolved in 60mL hydrochloric acid solution (50ml distilled water was diluted with 10ml concentrated hydrochloric acid solution), 20g FeCl 3 .6H 2 O was dissolved in 70mL distilled water; at a stirring speed of 100r / min, the dissolved FeCl 3 .6H 2 O solution added FeCl 2 .4H 2 After mixing evenly in the O solution, quickly add 100mL of ammonia water and continue to stir for 20min; place the stirred solution in a gradient magnetic field, the solution is clearly stratified, remove the supernatant, and wash the Fe with distilled water repeatedly. 3 o 4 magnetic particles; later in Fe 3 o 4 Add 40mL of concentrated nitric acid to the magnetic particles, slowly add 200mL of distilled water under magnetic stirring, and continue stirring for 50min. 3 o 4 The magnetic particle solution is placed in a gradient magnetic field, the supernatant is removed, and the ferric nitrate solution (40g Fe(NO 3 ) 3 .9H 2 O was dissolved in 80mL ...

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Abstract

The invention relates to a preparation method of gamma-Fe2O3 superparamagnetic nanoclusters. The method adopts gamma-Fe2O3 nanoparticles as anions, and uses a surfactant, polymer or protein as a cationic neutral block copolymer to react in a water solution so as to obtain gamma-Fe2O3 superparamagnetic nanoparticles, and controls the reactant ratio and reaction conditions to prepare gamma-Fe2O3 superparamagnetic nanoclusters of different shapes and sizes in different salt solutions. The preparation method has the advantages of simple operation, high success rate, good repeatability, and high product purity. Also the gamma-Fe2O3 superparamagnetic nanoclusters prepared by the method provided by the invention have the advantages of degradability, and controllable shape and size, etc., and can be applied to sustained drug release.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation and relates to a gamma-Fe 2 o 3 Preparation methods of superparamagnetic nanoclusters. Background technique [0002] Among many nanomaterials, γ-Fe 2 o 3 It has attracted much attention because of its wide application in magnetism, catalysis and gas sensing. With the continuous development of science and technology, nano-γ-Fe 2 o 3 The preparation methods of various methods are also constantly being innovated, and various methods are constantly crossing, infiltrating, learning from each other, and preparing many nanometer γ-Fe with excellent performance. 2 o 3 Particles, such as gas-sensing electrodes, specific and efficient catalysts, etc. Nano γ-Fe 2 o 3 Problems such as high processing temperature, easy agglomeration of particles, and difficulty in dispersing in the preparation process of methionine have always been difficult problems faced by scientific and technolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/02A61K47/18A61K47/32B82Y30/00C01G49/06
CPCA61K9/0009A61K47/02A61K47/183A61K47/32B82Y30/00C01G49/06C01P2004/04C01P2004/64
Inventor 刘小楠陈鑫姚卫棠晏敏皓
Owner SOUTHWEAT UNIV OF SCI & TECH
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