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Iridis tectori rhizome general flavone aglycone extract and preparation method and application thereof

A technology of total flavonoid aglycon and shegan aglycone, which is applied in the field of Sichuan shegan total flavonoid aglycone extract, can solve the problems of complex process, difficult drying of products, low product yield, etc., and achieve simple preparation process, excellent effect and high purity high effect

Active Publication Date: 2017-07-21
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its products are not total flavonoid aglycone (also contains glycosides), the yield of the product is low (the biggest reason is that the decoction pieces are boiled in water, and ingredients such as radix glycosides are not extracted), the product is not easy to dry, and the process is very complicated

Method used

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  • Iridis tectori rhizome general flavone aglycone extract and preparation method and application thereof
  • Iridis tectori rhizome general flavone aglycone extract and preparation method and application thereof
  • Iridis tectori rhizome general flavone aglycone extract and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention

[0029] Take 10kg of Chuanshegan crude drug crude powder, add 10L of 5% HCl aqueous solution, mix well, seal, place at room temperature for 15 days, place in a 100L enamel reaction kettle, heat and reflux with 40L of 95% ethanol to extract twice, 1 hour each time, The extracts were combined, concentrated under reduced pressure to 10 L, left overnight, precipitated, filtered, and washed with water until neutral. The precipitate was heated to reflux and dissolved in 5L of 95% ethanol, washed into 5L of boiling water, left overnight, precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brownish-yellow dry and loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 6 %, Shegan aglycon content 20.56%, total flavonoid aglycon content 51.42%.

Embodiment 2

[0030] Embodiment 2 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention

[0031] Take 10kg of Chuanshegan crude drug crude powder, add 10L of 5% HCl aqueous solution, mix well, seal, place at 45°C for 5 days, put it in a 100L enamel reaction kettle, heat and reflux with 40L of 95% ethanol to extract twice, each time After 1 hour, the extracts were combined, concentrated under reduced pressure to 10 L, left overnight, a precipitate precipitated, filtered, and washed with water until neutral. The precipitate was dissolved in 5L of 95% ethanol under reflux, washed into 5L of boiling water, left overnight, the precipitate was precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brown-yellow dry loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 7 %, Shegan aglycon content 21.25%, total flavonoid aglycon content 57.91%.

Embodiment 3

[0032] Embodiment 3 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention

[0033] Take 10kg of Chuanshegan crude drug crude powder, put it in a 100L enamel reaction kettle, add 40L of 5% HCl aqueous solution, heat and reflux for 10 hours for hydrolysis, filter, extract the dregs with 40L of 95% ethanol and heat and reflux twice for 1 hour each time, The extracts were combined, concentrated under reduced pressure to 10 L, left overnight, precipitated, filtered, and washed with water until neutral. The precipitate was heated to reflux and dissolved in 5L of 95% ethanol, washed into 5L of boiling water, left overnight, precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brownish-yellow dry loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 7.5 %, Shegan aglycon content 22.12%, total flavonoid aglycon content 53.38%.

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Abstract

The invention provides an iridis tectori rhizome general flavone aglycone extract. The general flavone aglycone content is higher than 50%w / w, the iridis tectori rhizome aglycone content is higher than 18%w / w, and the iridis tectori rhizome glucoside content is higher than 2%w / w. The invention further provides a preparation method of the iridis tectori rhizome general flavone aglycone extract. The preparation process of the iridis tectori rhizome general flavone aglycone extract is simple, the prepared aglycone extract is high in purity, and a pharmacodynamic test proves that the iridis tectori rhizome general flavone aglycone extract has obvious anti-inflammation and analgesic effects and is better than an iridis tectori rhizome general flavone extract in effect.

Description

technical field [0001] The invention relates to a total flavonoid aglycone extract of Chuanshegan, which belongs to the field of medicines. Background technique [0002] Chuanshegan is the dried rhizome of Iris tectorum Maxim., a plant of the family Irisaceae. It is a species recorded in the Pharmacopoeia. It is used for stagnation of heat, toxin, phlegm and fire, sore throat, excessive phlegm and salivation, cough and asthma, and its main medicinal ingredients are isoflavones. In recent years, it has been reported that the isoflavones in Chuanshegan have antiviral effects. For example, the patent application No. 20051002635.9 discloses that the total flavonoids extract of Chuanshegan has antiviral effects at the cellular level, and has anti-inflammatory, antipyretic, and antiviral properties. Pain, cough and other effects. Chuanshegan flavonoid capsules prepared from the total flavonoid extract of Chuanshegan have obtained the new drug certificate (National Medicine Certi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P29/00A61K125/00
CPCA61K36/88A61K2236/19A61K2236/333A61K2236/53A61K2236/55
Inventor 袁崇均陈帅罗森王笳张磊李利民谭正怀宁楠
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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