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Biocompatible water core microcapsule and preparation method thereof

A biocompatible, external-phase technology, applied in the field of preparing biocompatible water-core microcapsules, can solve the problems of uneven size of microcapsules, difficult to achieve effective control, low encapsulation efficiency, etc., and achieve good biocompatibility. Effect

Active Publication Date: 2020-05-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the secondary emulsification process, many micro-droplets wrapped in the oil phase are destroyed, and the inner phase and the outer phase are fused, so the encapsulation efficiency is low, and the finally obtained microcapsules are uneven in size, which is difficult to achieve effective control, thus Limiting the wide application of water core microcapsules in practice

Method used

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  • Biocompatible water core microcapsule and preparation method thereof
  • Biocompatible water core microcapsule and preparation method thereof
  • Biocompatible water core microcapsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Example 1: Preparation of water core microcapsules with uniform size and diameter of about 10 μm

[0038] Refer to attached figure 1 , using the method of the present invention to prepare biocompatible water core microcapsules, the specific steps are as follows: (1) making of microfluidic device: the silicon wafer is cleaned and then dried; then a layer of SU- 8 photoresist; by pre-designing the prepared mask plate, the photoresist on the silicon wafer is partially exposed under the ultraviolet lamp; the silicon wafer is placed in the developer, and the unexposed part is removed, so as to obtain channel structure; mix the PDMS prepolymer and crosslinking agent at a mass ratio of 10:1, then pour the mixture on the silicon wafer, and then bake and cure; the cured PDMS will replicate the channel on the silicon wafer, through Oxygen plasma and heat treatment bond PDMS and glass substrates to make microfluidic chips. The chip channel is attached figure 1 As shown, there i...

Embodiment 2

[0042] Example 2: The release of hydrophilic molecules of different molecular weights encapsulated in water-core microcapsules over time

[0043] (1) Dissolve 2 mg of hydrophilic molecules (fluorescein or fluorescein dextran) in 1 ml of the internal phase obtained in Example 1, and use this solution as a new internal phase to prepare encapsulated hydrophilic molecules according to Example 1 water core microcapsules;

[0044] (2) The microcapsules wrapped with hydrophilic molecules prepared in (1) are dispersed in the water phase, and the concentration of the hydrophilic molecules in the water phase is measured by a UV-visible spectrophotometer as a function of time; Larger, the release rate of hydrophilic molecules is correspondingly reduced (such as attached Figure 7 shown).

Embodiment 3

[0045] Example 3: Polyelectrolyte layer-by-layer encapsulation of the microcapsules prepared by the present invention

[0046]In neutral water, due to the partial ionization of the carboxyl group of shellac on the surface of the microcapsule, the microcapsule is negatively charged and can adsorb a layer of positively charged polyelectrolyte. Because of the complex configuration of the polymer polyelectrolyte, the positive polyelectrolyte neutralizes the negative charge on the surface of the microcapsule while the excess positive charge makes the surface of the microcapsule positively charged, and then a layer of negatively charged polyelectrolyte can be adsorbed. In the same way, while the negative polyelectrolyte neutralizes the positive charge on the surface of the microcapsule, the excess negative charge makes the surface of the microcapsule negatively charged. Figure 8 (a) shown).

[0047] (1) Adsorb a layer of positively charged polyelectrolyte: dissolve polydiallyldime...

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Abstract

The invention discloses biocompatible water-core microcapsules and a preparation method thereof. The method disclosed by the invention selects edible red lac with anti-oxidization and moisture-proof functions as a covering material; the red lac and hydrophilic molecules are dissolved into a mixed solution of water and ethanol at the volume ratio of 1 to 2; then the solution is emulsified into micro-drops with a uniform size by utilizing a microfluidic chip. The solubility of the red lac in the mixed solution is gradually reduced along with the gradual volatilization of the ethanol in the micro-drops; finally, the red lac is precipitated and separated out on the surfaces of the micro-drops and is finally cured to obtain the biocompatible water-core microcapsules for covering the hydrophilic molecules. The water-core microcapsules prepared by the preparation method adopt a microfluidic technology and take single emulsion as a template; a preparation process is simple and the prepared microcapsules have a uniform size and good biocompatibility and can cover the hydrophilic molecules to control the releasing of the hydrophilic molecules; the biocompatible water-core microcapsules have wide application value.

Description

technical field [0001] The invention relates to the field of microcapsules, in particular to a method for preparing biocompatible water-core microcapsules. Background technique [0002] Microcapsules with core-shell structure are widely used in various fields, especially biocompatible water-core microcapsules, which can wrap various important hydrophilic molecules in life and control their release. Therefore, the preparation of water-core microcapsules with controllable size and large-scale production is of great significance in various fields such as food, cosmetics, and drug delivery. The preparation of traditional water-core microcapsules mainly uses double emulsion as a template. First, the water phase is emulsified in the oil phase to obtain water-in-oil micro-droplets, and then the micro-droplets are emulsified twice in the water phase to obtain oil-in-water droplets. In the water-in-water double emulsion, as the solvent in the oil phase evaporates, the wrapping mater...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/12
CPCB01J13/12
Inventor 陈东孔琳琳孙泽勇陈然
Owner ZHEJIANG UNIV
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