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Polymer fluorescent material for biological detection and preparation method thereof

A fluorescent material and biological detection technology, applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of poor biocompatibility, damage to organisms, etc., and achieve the effect of reducing damage and low energy

Active Publication Date: 2017-08-08
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing polymers have problems such as poor biocompatibility and certain damage to organisms.

Method used

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  • Polymer fluorescent material for biological detection and preparation method thereof
  • Polymer fluorescent material for biological detection and preparation method thereof
  • Polymer fluorescent material for biological detection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A polymer fluorescent material that can be used for biological detection, and its structural formula is as follows:

[0027]

[0028] where R 1 for -C 6 H 13 , R 2 for -C 8 H 17 .

[0029] The preparation method of the above-mentioned polymer fluorescent material comprises the following steps:

[0030] a) To a 500 mL two-necked flask, add compound (1) (3 g, 5.51 mmol), compound (2) (3.22 g, 6.61 mmol), Pd (PPh) 3 ) 4 (636mg, 0.55mmol), and toluene (60mL) / EtOH (10mL) / 2M K 2 CO 3 Aqueous solution (10 mL), the system was deoxygenated and refluxed with stirring overnight under nitrogen protection. After cooling, the reaction solution was poured into 100 mL of distilled water, the organic phase was collected and washed twice with distilled water (100 mL*2), the organic phase was dried with anhydrous magnesium sulfate and then concentrated, and subjected to column chromatography (petroleum ether: dichloromethane=2:1) , volume ratio) and purified to obtain 4.01 g...

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Abstract

The invention relates to a polymer fluorescent material for biological detection and a preparation method thereof. The compound has a structure as follows: a formula is shown in the description, wherein R1 and R2 represent alkyl with the carbon atom number of 1 to 20 and a value range of n is between 0 and 1. According to the polymer fluorescent material, modification and improvement are carried out on the basis of an existing semiconductor polymer, so that the semiconductor polymer can be excited by light with long wavelength and damages to organisms are reduced; meanwhile, a tetraphenylethylene group is added so that fluorescent light under a solid state or a semi-solid state of the polymer can be enhanced.

Description

technical field [0001] The invention belongs to the technical field of polymer synthesis, in particular to a polymer fluorescent material that can be used for biological detection and a preparation method thereof. Background technique [0002] Organic dyes appear to be the most versatile fluorophores for bioimaging and bioanalysis. A variety of dye molecules, such as fluorescein, rhodamine, and cyanine, are available for different experiments, and their optical properties can be tuned by various design strategies. However, the inherent limitations of traditional dyes, such as low absorptivity and poor light fastness, pose great difficulties for their further development. Therefore, it is necessary to design and synthesize brighter and more stable fluorescent probes, and polymers have excellent fluorescence brightness, large optical absorption cross-section, fast emission rate, excellent photostability, and non-toxicity due to their extremely outstanding fluorescence brightn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C08G61/12
CPCC08G61/124C08G61/126C08G2261/124C08G2261/145C08G2261/31C08G2261/3223C08G2261/3241C08G2261/3246C08G2261/411C08G2261/522C09K11/06C09K2211/1483
Inventor 刘治田刘明高翔张晓璐李子彧张旗
Owner WUHAN INSTITUTE OF TECHNOLOGY