3D printer and 3D printing method of sodium alginate hydrogel

A 3D printer, sodium alginate technology, applied in medical science, processing and manufacturing, liquid material additive processing, etc., can solve problems such as tissue engineering that cannot be practically used, achieve large-scale promotion and application, good biocompatibility , the preparation method is simple

Inactive Publication Date: 2017-09-08
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this type of hydrogel material cannot be practically used in the field of tissue engineering.

Method used

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  • 3D printer and 3D printing method of sodium alginate hydrogel
  • 3D printer and 3D printing method of sodium alginate hydrogel
  • 3D printer and 3D printing method of sodium alginate hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) The 3D printer uses a small 1ml syringe as the hydrogel extruder, the needle diameter of the small syringe is 2mm, and the large syringe is 100ml.

[0038] (2) Prepare sodium alginate aqueous solution for 3D printing ink: Weigh 6 grams of sodium alginate solid powder, dissolve it in 190 ml of deionized water, heat it in a water bath at 60 degrees Celsius, and keep stirring until uniform, and ultrasonically treat it to remove bubbles, that is, viscous sol-like sodium alginate solution.

[0039] (3) Use a 100ml large syringe to absorb the sol-like sodium alginate solution, fix it on the bracket of the peristaltic pump, use a silicone tube with an inner diameter of 3 mm to connect the head of the large syringe and the tail of the small syringe, and pre-fill the sol-like alginate The sodium solution is squeezed into a small syringe filled with silicone tubing, and the extrusion speed of the peristaltic pump is set to 5 ml / min.

[0040] (4) Place a liquid tank on the 3D...

Embodiment 2

[0045] Utilize the 3D printer of the present invention, adopt the small syringe needle that pipe diameter is 4 millimeters. The preparation and printing steps of the printing material are the same as the steps (2) to (7) of Example 1, wherein the extrusion speed of the peristaltic pump is changed to 10 ml / min. Take out the formed hydrogel from the calcium ion solution and print out continuous, uniformly thick and thin line-shaped hydrogel. The hydrogel of this example is thicker than the hydrogel obtained in Example 1, as figure 2 As shown in the middle picture.

Embodiment 3

[0047] Utilize the 3D printer of the present invention, adopt the small syringe needle that pipe diameter is 4 millimeters. When preparing the sodium alginate aqueous solution for 3D printing ink, add methyl orange as a color reagent. The specific method is: weigh 6 grams of sodium alginate solid powder and 0.5 mg of methyl orange powder, dissolve them in 190 ml of deionized water, Heated in a water bath at 60 degrees Celsius, and continued to stir until uniform, and ultrasonically treated to remove air bubbles, and an orange sol-like sodium alginate solution was obtained. The printing steps are the same as the steps (3) to (7) of Example 1, and the orange continuous, uniform thickness linear sodium alginate hydrogel can be obtained. The thickness of the hydrogel in this example is equivalent to that of the hydrogel obtained in Example 2. ,Such as figure 2 Shown on the right.

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PUM

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Abstract

The invention discloses a 3D printer and a 3D printing method of a sodium alginate hydrogel. According to the method, a sol-like sodium alginate taken as a printing raw material is solidified through a calcium ion solution, and the sodium alginate hydrogel in a certain three-dimensional shape is obtained through 3D printing. The sodium alginate hydrogel printed by the method is in a continuous and uniform-thickness line shape and has good strength and toughness; a hydrogel model in a specific 3D shape can be prepared by the layer-upon-layer stacked printing method, the hydrogels with different colors or different functions can be obtained by adding pigments of different colors or materials with different functions. The method is simple to operate, safe and environmentally friendly, and cost is low; the method can be used for printing the sodium alginate hydrogel with a 3D structure on a large scale, and a material basis is provided for research areas such as tissue engineering, simulation robots and biosensors, which involve soft body sensing materials.

Description

technical field [0001] The invention relates to the technical field of three-dimensional printing materials, in particular to a 3D printer and a method for 3D printing sodium alginate hydrogel. Background technique [0002] 3D printing technology has high precision, high efficiency and easy operation, so it has great application prospects in electronic technology, automation, aerospace, medical engineering and other fields. In recent years, this technology has also been widely used in the preparation of biological tissue engineering materials, such as printing artificial bones, vascular tissues and cartilage structures. Hydrogel, a commonly used material in the field of tissue engineering, is also an ideal printable biomaterial known as "bioink". However, at present, hydrogels are mostly used as the carrier of cell culture in tissue engineering, and there are few methods and processes for preparing hydrogel scaffolds using 3D printing technology alone, which need further re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/106B29C64/20A61L27/20A61L27/52B33Y10/00B33Y30/00B33Y70/00
CPCA61L27/20A61L27/52B33Y10/00B33Y30/00B33Y70/00C08L5/04
Inventor 毕红谢萍萍金青青张翔
Owner ANHUI UNIVERSITY
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