Preparation of heparin and Cu on the surface of biomaterials 2+ Method of Mesoporous Silicon Nanoparticle Coating
A nanoparticle and biomaterial technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve the problem that the fixed amount of heparin on the surface is difficult to ensure the long-term sustained effect of intravascular implant materials, and it is difficult to ensure the sustained and controlled release of heparin. Its activity and other issues can achieve good blood compatibility, improve the success rate of implantation, and improve the effect of biocompatibility
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Embodiment 1
[0046] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:
[0047] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;
[0048] 2) Then load heparin and Cu in the mesoporous channels 2+ ;
[0049] 3) Then modify the nanoparticle surface with albumin;
[0050] 4) Finally, the nanoparticles were immobilized on the surface of the dopamine-modified biomaterial to obtain MSN-NH 2 Coating of @He / Cu.
[0051] In said step 1), the method for surface modification of mesoporous silicon nanoparticles is:
[0052] 1.1) fully mixing the mesoporous silicon nanoparticles and the aminosilane molecular solution;
[0053] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;
[0054] 1.3) wash with ethanol three times;
[0055] 1.4) Under the condition of 80 degrees Celsius, MSN-NH was obtained after vacuum drying 2 .
...
Embodiment 2
[0074] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:
[0075] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;
[0076] 2) Then load heparin and Cu in the mesoporous channels 2+ ;
[0077] 3) Then modify the nanoparticle surface with albumin;
[0078] 4) Finally, the nanoparticles were immobilized on the surface of the dopamine-modified biomaterial to obtain MSN-NH 2 Coating of @He / Cu.
[0079] In said step 1), the method for surface modification of mesoporous silicon nanoparticles is:
[0080] 1.1) fully mixing the mesoporous silicon nanoparticles and the aminosilane molecular solution;
[0081] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;
[0082] 1.3) wash with ethanol three times;
[0083] 1.4) Under the condition of 80 degrees Celsius, MSN-NH was obtained after vacuum drying 2 .
...
Embodiment 3
[0102] Preparation of heparin and Cu on the surface of biomaterials 2+ A method for coating mesoporous silicon nanoparticles, comprising the steps of:
[0103] 1) Firstly, the surface of mesoporous silicon nanoparticles is modified to obtain MSN-NH 2 ;
[0104] 2) Then load heparin and Cu in the mesoporous channels 2+ ;
[0105] 3) Then modify the nanoparticle surface with albumin;
[0106] 4) Finally, the nanoparticles were immobilized on the surface of the dopamine-modified biomaterial to obtain MSN-NH 2 Coating of @He / Cu.
[0107] In said step 1), the method for surface modification of mesoporous silicon nanoparticles is:
[0108] 1.1) fully mixing the mesoporous silicon nanoparticles and the aminosilane molecular solution;
[0109] 1.2) Shake the reaction for 30 hours, and collect the nanoparticles by centrifugation;
[0110] 1.3) wash with ethanol three times;
[0111] 1.4) Under the condition of 80 degrees Celsius, MSN-NH was obtained after vacuum drying 2 .
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