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Soluble molecularly-imprinted polymer and application thereof

A molecularly imprinted and polymer technology, applied in the analysis of materials, material analysis by electromagnetic means, instruments, etc., can solve the problem of difficult to obtain sensitive membranes, insoluble, and not yet soluble molecularly imprinted polymers. Soluble molecularly imprinted polymer membrane ions Detection and reporting problems, to achieve the effect of enhancing molecular recognition ability and improving response performance

Active Publication Date: 2017-09-29
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it was found that most molecularly imprinted polymers used as recognition carriers are mostly rigid high molecular weight polymers with large molecular weight, which makes them insoluble in plasticizers (they can only be simply "dispersed" in the sensitive membrane phase in the form of particles). middle), it is difficult to obtain a homogeneous sensitive film, which greatly reduces the effective bonding sites in the organic film phase
In addition, in the current study of molecularly imprinted polymer membrane ion-selective electrodes, all molecularly imprinted polymers are insoluble, and the synthesis of soluble molecularly imprinted polymers and the detection of ion selectivity of soluble molecularly imprinted polymer membranes have not yet been carried out. report

Method used

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  • Soluble molecularly-imprinted polymer and application thereof
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  • Soluble molecularly-imprinted polymer and application thereof

Examples

Experimental program
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Embodiment 1

[0035] Take the detection of phenolic pollutant molecules in river water by the present invention: bisphenol AF as an example. Its determination steps are as follows:

[0036] 1) Preparation of molecularly imprinted polymers:

[0037] a. Preparation of insoluble molecularly imprinted polymer: Take 0.5 mmol of bisphenol AF and 2 mmol of pre-vacuum distilled methacrylic acid monomer into a 50 mL round bottom flask, and then add 10 mmol of crosslinking agent diethylene to the above mixture Benzene, 25 mg of initiator azobisisobutyronitrile and 12.5 mL of acetonitrile, ultrasonically oscillate for 5 min, and after mixing uniformly, finally pass nitrogen gas for 15 min to remove the oxygen present in the reaction solution, and seal it. The above reaction vessel was moved to an oil bath and heated at 80°C for 24 hours to obtain white solid particles.

[0038] The above-mentioned white solid particles were alternately washed three times with methanol / acetic acid (8:2, v / v) mixed so...

Embodiment 2

[0046] The difference from Example 1 is that the detection of bisphenol AF, a phenolic pollutant molecule in river water, is taken as an example. Its determination steps are as follows:

[0047] Preparation of Molecularly Imprinted Polymers:

[0048] a. Preparation of insoluble molecularly imprinted polymer: Take 0.5mmol of bisphenol AF and 2mmol of methacrylic acid monomer pre-vacuum distilled into a 50mL round bottom flask, and then add 10mmol of cross-linking agent di to the above mixture Vinylbenzene, 25 mg of initiator azobisisobutyronitrile and 12.5 mL of acetonitrile were vibrated ultrasonically for 5 minutes. After mixing evenly, nitrogen gas was flowed for 15 minutes to remove the oxygen existing in the reaction solution, and sealed. The above reaction vessel was moved to an oil bath and heated at 80°C for 24 hours to obtain white solid particles.

[0049] The above-mentioned white solid particles were alternately washed three times with methanol / acetic acid (8:2, v...

Embodiment 3

[0052] The difference from Example 1 is that the detection of bisphenol AF, a phenolic pollutant molecule in river water, is taken as an example. Its determination steps are as follows:

[0053] Preparation of Molecularly Imprinted Polymers:

[0054] a. Preparation of insoluble molecularly imprinted polymer: Take 0.5mmol of bisphenol AF and 2mmol of methacrylic acid monomer pre-vacuum distilled into a 50mL round bottom flask, and then add 10mmol of cross-linking agent di to the above mixture Vinylbenzene, 25 mg of initiator azobisisobutyronitrile and 12.5 mL of acetonitrile were vibrated ultrasonically for 5 minutes. After mixing evenly, nitrogen gas was flowed for 15 minutes to remove the oxygen existing in the reaction solution, and sealed. The above reaction vessel was moved to an oil bath and heated at 80°C for 24 hours to obtain white solid particles.

[0055] The above-mentioned white solid particles were alternately washed three times with methanol / acetic acid (8:2, v...

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Abstract

The invention relates to a potential sensor and particularly relates to a soluble molecularly-imprinted polymer and application thereof. A preparation method of the soluble molecularly-imprinted polymer comprises the following steps: adding a swelling solvent into a molecularly-imprinted polymer, heating, stirring and swelling at 50-150 DEG C, and fully dissolving the polymer to obtain the soluble molecularly-imprinted polymer, wherein the swelling solvent is tetrahydrofuran, dimethylformamide, chloroform or 1,2,4-trichlorobenzene. Through the method, the problem that the conventional molecularly-imprinted polymer is difficultly dissolved in a potential sensor sensitive membrane is effectively solved by a solubilizer on the basis that the high-selectivity adsorption capacity of the molecularly-imprinted polymer is retained; a polymer sensitive membrane doped in the molecularly-imprinted polymer forms a homogeneous system, so that the molecular recognition capability of the molecularly-imprinted polymer sensitive membrane can be enhanced to a great extent, and then the response performance of the potential sensor can be improved.

Description

technical field [0001] The invention relates to a potential sensor, in particular to a soluble molecularly imprinted polymer and its application. Background technique [0002] Ion-selective electrodes are an important branch of chemical sensors, and this type of electrodes has become a new hot spot in the field of chemical sensors since the 1990s. Chemical sensors have been widely used in environmental, clinical, food safety and other fields because of their advantages such as simple operation, convenient portability, and continuous and rapid detection of analytes. of new fields. [0003] Molecularly imprinted polymers are new functional materials developed in recent years with molecular recognition capabilities. They have the characteristics of predetermined structure and activity, specific recognition, and wide practicability. Harsh environment. At present, molecularly imprinted polymers have been widely used in chromatographic separation, solid phase extraction, biomim...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F220/06C08J9/26C08J3/09G01N27/333
CPCC08F212/36C08J3/093C08J3/095C08J3/096C08J9/26C08J2201/0422C08J2325/02G01N27/3335C08F220/06
Inventor 秦伟张欢梁荣宁姚瑞清
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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