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Simple preparation method of sulfydryl-modified gold nanocluster and application of sulfydryl-modified gold nanocluster in oxygen quantitative detection

A gold nanocluster and sulfhydryl modification technology, which is applied in the preparation and application of functional nanomaterials, can solve the problems of not meeting the needs of oxygen content detection, difficult oxygen real-time monitoring, complex synthesis process, etc., to achieve repeated use, easy promotion, Good biocompatibility effect

Active Publication Date: 2017-10-13
ZHEJIANG NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the vast majority of phosphorescence quenching methods use metal-organic framework materials and porous phosphorescent materials, but the synthesis of oxygen probes based on these materials requires a complex synthesis process, and the sensitivity of this method is not high and it is difficult to apply to oxygen. real-time monitoring
Since these methods are all based on the phosphorescent quenching process, the mode of signal reduction is not an ideal detection mode and is often interfered by other quenchers
In addition, most organic framework materials and porous materials have poor water solubility, so they are mostly used to detect the oxygen content in organic solvents. These shortcomings make this type of method unable to meet the detection needs of oxygen content in actual water

Method used

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  • Simple preparation method of sulfydryl-modified gold nanocluster and application of sulfydryl-modified gold nanocluster in oxygen quantitative detection
  • Simple preparation method of sulfydryl-modified gold nanocluster and application of sulfydryl-modified gold nanocluster in oxygen quantitative detection
  • Simple preparation method of sulfydryl-modified gold nanocluster and application of sulfydryl-modified gold nanocluster in oxygen quantitative detection

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Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1: One-step method for synthesizing gold nanoclusters modified by dithiothreitol

[0031] Such as figure 1 As shown, ① Deoxygenate three times distilled water, add 0.6 mol / L chloroauric acid solution 166.8 µL and 50 mmol / L dithiothreitol solution 6 mL under nitrogen protection, and stir for 20 ~ 40 minutes, then adjust the pH of the solution to 8.0 with NaOH, until the precipitate is completely dissolved, and obtain the dithiothreitol-modified gold nanocluster polymer; ② place the above-mentioned dithiothreitol-modified gold nanocluster polymer in Add sodium dithionite to the water, then add hydrochloric acid to adjust the pH to 5, and then add hydrochloric acid to strong acidity after filtration, gold nano-cluster solids are precipitated, and the solids are vacuum-dried to obtain dithiothreitol-modified gold nano-clusters.

[0032] Compared figure 2 A and Figure 5 ,Such as figure 2The TEM imaging results in A show that the prepared dithiothreitol-mod...

Embodiment 2

[0035] Embodiment 2: the method for one-step synthesis of dimercaptosuccinic acid modified gold nanoclusters

[0036] ① Deoxygenate triple distilled water, add 166.8 µL of 0.6 mol / L chloroauric acid solution and 6 mL of 50 mmol / L dimercaptosuccinic acid solution under nitrogen protection, and stir for 20 to 40 minutes under airtight room temperature conditions , adjust the pH of the solution to 8.0 with NaOH, until the precipitate is completely dissolved, and obtain the gold nanocluster polymer modified by dimercaptosuccinic acid; ② put the prepared gold nanocluster polymer modified by dimercaptosuccinic acid in water, add Sodium dithionite, then adding hydrochloric acid to adjust the pH to 5, and then adding hydrochloric acid to strong acidity after filtration, gold nanocluster solids are precipitated, and the solids are vacuum-dried to obtain dimercaptosuccinic acid-modified gold nanoclusters.

[0037] Characterized by TEM and XPS, the dimercaptosuccinic acid-modified gold n...

Embodiment 3

[0039] Embodiment 3: the method for the gold nanocluster of one-step synthesis lipoic acid modification

[0040] ① Deoxygenate three times distilled water, add 166.8 µL of 0.6 mol / L chloroauric acid solution and 6 mL of 50 mmol / L lipoic acid solution under nitrogen protection, stir for 20 to 40 minutes under airtight room temperature conditions, and dissolve with NaOH Adjust the pH of the solution to 8.0 until the precipitate is completely dissolved to obtain a lipoic acid-modified gold nanocluster polymer; ② put the above-mentioned lipoic acid-modified gold nanocluster polymer in water, add sodium dithionite, and then add hydrochloric acid to adjust the pH to 5. After filtering, add hydrochloric acid to strong acidity, gold nanocluster solids are precipitated, and the solids are vacuum-dried to obtain non-fluorescent lipoic acid-modified gold nanoclusters.

[0041] Characterized by TEM and XPS, lipoic acid-modified gold nanoclusters and dithiothreitol-protected gold nanoclust...

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Abstract

The invention belongs to the technical field of preparation and application of functional nano materials, and particularly relates to a simple preparation method of a sulfydryl-modified gold nanocluster and an application of the sulfydryl-modified gold nanocluster in oxygen quantitative detection, and develops quick oxygen detection test paper for detecting oxygen. The preparation method comprises the following steps: placing chloroauric acid and a polysulfhydryl compounds in deoxygenated water, introducing nitrogen for protection, stirring for 20 to 40 min under a closed room-temperature condition, regulating a pH to 8 by utilizing NaOH, obtaining the sulfydryl-modified gold nano cluster polymer, adding the sulfydryl-modified gold nanocluster polymer into the water, adding sodium hydrosulfite, then adding a hydrochloric acid to adjust the pH to 5, filtering, adding hydrochloric acid to be in strong acidity, precipitating gold nanocluster solids, vacuum drying the solids, and obtaining the sulfydryl-modified gold nanocluster. The prepared sulfydryl-modified gold nano cluster has the characteristics of good solubility, good selectivity and high sensitivity, and can realize the sensitive detection of the content of oxygen and gaseous oxygen in the water.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of functional nanomaterials, and in particular relates to a simple preparation method of thiol-modified gold nanoclusters and its application in oxygen quantitative detection, and develops oxygen rapid detection test paper for oxygen detection. Background technique [0002] In food science, environmental monitoring and medical applications, the detection of dissolved oxygen content is necessary and very meaningful. In the past few decades, the detection methods of dissolved oxygen have made great progress, mainly including Winkler detection method, electrochemical detection method, phosphorescence quenching detection method. In addition to the above-mentioned methods for detecting dissolved oxygen, scientists have also developed a variety of detection methods such as colorimetry, gas chromatography, etc., but these methods have many problems such as low detection sensitivity an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/643
Inventor 钱兆生敖航丰慧
Owner ZHEJIANG NORMAL UNIVERSITY
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