Antibacterial silk fibroin material and preparation method thereof

Abstract

The invention discloses an antibacterial silk fibroin material and a preparation method thereof. The antibacterial silk fibroin material is prepared from the components: silk fibroin and berberine, wherein the berberine is directly bonded with the silk fibroin through an intermolecular force. The method comprises the steps of preparing a silk fibroin solution, preparing a silk fibroin composite material, preparing the antibacterial silk fibroin material treated through water vapor, and preparing a glycerinum modified silk fibroin composite material modified. According to the antibacterial silk fibroin material provided by the invention, the silk fibroin is subjected to water vapor treatment and glycerinum modification, a secondary structure of the silk fibroin is changed, the antibacterial agent berberine can be uniformly dispersed into silk fibroin macromolecule absorbable materials, and the antibacterial agent is slowly released along with the swelling and the degrading of the silk fibroin macromolecule absorbable materials, so that the antibacterial silk fibroin material has long-acting slow-release mold resistance, can effectively prevent wound infection and promote heating aiming at 3 days of high risk periods of tissue infection, and can provide a new solution for coating materials, biological dressings or medical instruments.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a medical antibacterial material and a preparation method thereof, in particular to an antibacterial silk fibroin material and a preparation method thereof. Background technique [0002] Medical sutures are the most common surgical implantable biomedical textiles, which are widely used in various surgical operations for suturing wounds, connecting tissues and vascular ligation. However, sutures with a braided structure tend to absorb and harbor bacteria in the gaps and between single fibers, which increase the incidence of surgical site infections. Surgical site infection not only affects wound healing, brings pain to patients, prolongs hospital stay, but also increases the economic burden of patients and society, and is even an important cause of postoperative complications and even death. Sutures are the channel for bacteria to enter the surgical incision. If the sutures have...

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Problems solved by technology

But, the use of antibiotics has been strictly regulated in the world to avoid the abuse of antibiotics and reduce the emergence of drug-resistant strains; (2) silver ion-containing antibacterial agent coated sutures (Chinese Patent Publication No. ); However, due to the oxidation reaction of silver ion antibacterial agents in the preparation process, the antibacterial performance is reduced, and the possible instability of silver ions is not conducive to human health; (3) Chinese herbal medicine antibacterial agent coated sutures (Chinese Patent Publication No. CN101584878A and Publication No. CN101584595A), utilizing the antibacterial properties of traditional Chinese medicine, impregnated or coated sutures with traditional Chinese medicines have antibacterial properties, but the antibacterial medical sutures produced by this process have a short antibacterial drug sustained release time, and the antibacterial no significant effect

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