Recombinant chicken long-acting interferon gamma, fusion protein for preparing recombinant chicken long-acting interferon gamma, and preparation method of fusion protein

Abstract

The invention discloses a recombinant chicken long-acting interferon gamma, a fusion protein for preparing the recombinant chicken long-acting interferon gamma, and a preparation method of the fusion protein; the fusion protein is formed by linking chicken interleukin 2 and chicken interferon gamma via a flexible linker; the fusion protein is mixed with a lyoprotectant, and the mixture is lyophilized to obtain the recombinant chicken long-acting interferon gamma. The recombinant chicken long-acting interferon gamma can provide significantly extended half-life period for chicken interferons which is more than 13 times longer than that of common chicken interferons, has broad-spectrum antiviral action, and can improve autologous immune response of chicken.

Description

technical field

[0001] The invention belongs to the technical field of biogenetic engineering, and specifically relates to a recombinant chicken peginterferon gamma, a fusion protein for preparing the peg interferon gamma and a preparation method thereof. Background technique

[0002] In recent years, with the scale of the breeding industry and the rapid development of the circulation of livestock and poultry and their products, China's poultry industry has made great progress, forming a huge industry with an annual output value of more than 100 billion yuan. However, due to our country's weak animal epidemic prevention system, poultry disease is still a serious problem facing poultry production in our country, which has become an important factor restricting the development of poultry breeding industry in our country. There are many poultry diseases and large losses, the mortality rate is higher than 15%, and the death rate is 20% to 25% (less than 5% in developed countries...

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