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A kind of preparation method of gelatin/plant polysaccharide composite hemostatic sponge

A technology of plant polysaccharides and hemostatic sponges, applied in surgical adhesives, medical science, surgery, etc., can solve the problems of high price and immunogenicity, and achieve the advantages of simple method, easy-to-obtain raw materials, comfortable softness and resilience Effect

Active Publication Date: 2019-09-13
稳得希林(杭州)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the Chinese patent application CN 105727347 A, chitosan, starch and gelatin are compounded to make a hemostatic sponge. The defect is that genipin must be added as a cross-linking agent, which is expensive, and chitosan is obtained from animals, which may cause immunogenic
[0006] The technology of making hemostatic sponge with gelatin and plant polysaccharide compound has not been reported in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation method of gelatin / plant polysaccharide composite hemostatic sponge, the steps are as follows:

[0036] 1) Weigh 1.0g of sodium alginate and dissolve it in 100mL of deionized water, add 5mL of sodium periodate solution (0.1g / mL) to it, and stir for 8 hours; add 1mL of ethylene glycol dropwise, and stir for 2 hours. Dialyzed and freeze-dried to obtain modified sodium alginate 1;

[0037] 2) Dissolve 3.0g of gelatin in 50mL of deionized water, add 3.0g of glycerin, 50mL of modified sodium alginate 1 solution (1.0g) and 0.5g of foaming agent, stir and react in a water bath at 40°C for 2 hours, and mix the foam obtained after the reaction. The foam solution is poured into a mold, frozen in a refrigerator, freeze-dried in a freeze dryer, and then heat-treated at 50°C for 24 hours to obtain a gelatin / formylated modified plant polysaccharide composite hemostatic sponge.

Embodiment 2

[0039] The preparation method of gelatin / plant polysaccharide composite hemostatic sponge, the steps are as follows:

[0040] 1) Weigh 1.0g of sodium alginate and dissolve it in 100mL of deionized water, add 1mL of sodium periodate solution (0.1g / mL) to it, and stir for 6h; add 1mL of ethylene glycol dropwise, and stir for 1h, then Dialyzed and freeze-dried to obtain modified sodium alginate 2;

[0041] 2) Dissolve 1.0g of gelatin in 50mL of deionized water, add 2.0g of glycerin and 50mL of modified sodium alginate 2 solution (3.0g), stir and react in a water bath at 50°C for 6 hours, and pour the reaction solution obtained after the reaction into the mold, Freeze in a refrigerator, freeze-dry in a freeze dryer, and heat-treat at 50°C for 48 hours to obtain a gelatin / formylated modified plant polysaccharide composite hemostatic sponge.

Embodiment 3

[0043] The preparation method of gelatin / plant polysaccharide composite hemostatic sponge, the steps are as follows:

[0044] Dissolve 2.5g of gelatin in 50mL of deionized water, add dropwise 3.0g of glycerin, 40mL of sodium alginate solution (1.0g) and 1.0g of foaming agent, stir in a water bath at 50°C for 6 hours, and pour the foaming solution into the mold , and then frozen in the refrigerator, and freeze-dried in a freeze dryer, and after heat treatment at 50°C for 36 hours, the gelatin / plant polysaccharide composite hemostatic sponge can be obtained.

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PUM

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Abstract

The invention discloses a preparation method of gelatin / plant polysaccharide composite hemostatic sponge. The preparation method of the gelatin / plant polysaccharide composite hemostatic sponge is characterized by comprising the following steps: S1, dissolving gelatin in hot water, adding plant polysaccharide solution into the gelatin solution, and carrying out mixing and stirring reaction; and S2, transferring the reaction liquid after the mixing and stirring reaction into a mould, carrying out low-temperature freeze drying, and carrying out heat treatment, thus obtaining the gelatin / plant polysaccharide composite hemostatic sponge. The sponge prepared by adopting the preparation method disclosed by the invention has excellent hemostatic property, and can rapidly absorb liquid when contacting a wound, the aggregation of blood platelets and hemoglobin is accelerated, bleeding is stopped rapidly, and the bleeding stopping time is less than or equal to 60 seconds.

Description

technical field [0001] The invention relates to a medical hemostatic material, which belongs to the technical field of biomedical materials, in particular to a preparation method of a gelatin / plant polysaccharide composite hemostatic sponge. Background technique [0002] Extensive wound bleeding caused by trauma threatens people's lives. Quick and effective hemostasis can stabilize the injury and create conditions for follow-up treatment. [0003] Gelatin is a widely used natural biomacromolecule with good biocompatibility and nontoxicity. Gelatin is also a kind of fibrin. It has a large number of carboxyl groups, hydroxyl groups and amino groups in its molecular structure, and has strong hydrophilicity. Therefore, gelatin hemostatic sponge is widely used in clinical practice. However, gelatin itself has poor mechanical properties, so gelatin-based biomaterials are usually modified. In Chinese patent application CN 102247615 A, it is disclosed that polycaprolactone and gel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00
Inventor 徐福建罗旭李杨胡杨苏洋
Owner 稳得希林(杭州)生物科技有限公司
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