Calcitriol liquid hard capsule, method for preparing same and application of calcitriol liquid hard capsule

Abstract

The invention provides a calcitriol liquid hard capsule, a method for preparing the same and application of the calcitriol liquid hard capsule. Every 1000 calcitriol liquid hard capsules comprise 0.25-0.5 mg of calcitriol, 140-170 g of oil-based matrixes and 25-40 mg of antioxidants. The method includes mixing the antioxidants and the oil-based matrixes with one another to obtain first mixtures; stirring and dissolving the first mixtures and then adding the calcitriol into the first mixtures to obtain second mixtures; continuing to stir and dissolve the second mixtures and then vacuumizing and degassing the second mixtures; filling hard capsule shells with the mixtures to obtain the calcitriol liquid hard capsule. The calcitriol liquid hard capsule, the method and the application have the advantages that the calcitriol liquid hard capsule can be effectively applied to treating post-menopause and senile osteoporosis, chronic renal failure and the like; the content uniformity of the calcitriol liquid hard capsule which is a medicine can be improved, the calcitriol liquid hard capsule is good in stability, long in quality guarantee period, high in bioavailability, low in cost and convenient to administer, and accordingly the calcitriol liquid hard capsule, the method and the application have obvious merits.

Description

technical field [0001] The invention relates to the field of calcitriol capsule manufacture, in particular to a calcitriol liquid hard capsule and a preparation method and application thereof. Background technique [0002] Osteoporosis is a systemic skeletal disease of multiple causes, characterized by decreased bone strength and increased risk of fracture. Osteoporosis and the fractures it causes rank seventh among current common diseases, seriously threatening the health of middle-aged and elderly people, and becoming a global public health problem. By 2050, it is estimated that the incidence of osteoporosis in my country's population will rise from 6.6% (1997) to 13.6%. The serious clinical consequence of osteoporosis is fracture. The incidence of osteoporosis in the elderly over 60 years old is as high as 55%, and the incidence of fracture is about 10%. The resulting complications lead to death within 1 year, and more than 50% of the survivors cannot walk or have mobil...

AI Technical Summary

Problems solved by technology

[0013] The first object of the present invention is to provide a calcitriol liquid hard capsule, which is made of an oily base, and the active ingredients are directly dissolved in the oily liquid and filled in the hard capsule, which overcomes the problem of poor drug solubility, In order to clarify the true solution instead of the traditional powder form, the drug can be uniformly dispersed in the liquid excipient, which improves the content uniformity of the drug, has good stability, long shelf life, high bioavailability, low cost, and convenient administration, with obvious advantages

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