A traditional Chinese medicine powder for external use in combination with radiotherapy for the treatment of malignant body surface ulcers

A technology for topical powders and body surface ulcers, applied in drug combination, drug delivery, and pharmaceutical formulations, can solve problems such as ineffective antibiotic treatment, incomplete resection of tumors, poor blood supply of malignant ulcers, etc., and achieve good clinical practice results , Facilitate preparation and use, relieve pain and discomfort

Active Publication Date: 2021-02-26
THE AFFILIATED HOSPITAL OF QINGDAO UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The fundamental treatment for malignant surface ulcers is to kill tumors, such as local radiotherapy, which can kill most tumor tissues on the ulcer surface, thus providing the possibility for ulcer healing. However, most malignant surface ulcers that have undergone radiotherapy still cannot achieve ideal healing. The reasons are as follows: 1. Radiotherapy can cause radioactive skin damage, which may enlarge the ulcer surface and aggravate the ulcer; 2. Radiotherapy causes a large amount of tumor tissue necrosis, and the necrotic tissue is very prone to concurrent infection. If it cannot be effectively controlled, it may also aggravate the infection. Ulcers; 3. After radiotherapy, there are still some tumor tissues remaining. If not controlled in time, it may cause resurgence
[0004] For malignant surface ulcers that cannot heal after radiotherapy, the commonly used treatment methods are: 1. Surgical debridement—however, since the patient did not choose surgery before radiotherapy, it means that most of the tumors cannot be completely removed. Cannot completely debride the wound, surgical debridement is of little significance, and may lead to tumor spread or wound expansion; 2. Local dressing change: keeping the wound clean, timely disinfection and dressing change are common treatments to prevent wound infection and promote wound healing, but malignant Ulcers with deep wounds, severe infection and residual tumors, simply changing the dressing is difficult to be effective; 3. Antibiotics are used for co-infection, but the blood supply of malignant ulcers is poor, and the effect of antibiotics is often ineffective
[0005] So far, there is no literature report on traditional Chinese medicine externally used directly for malignant body ulcers or combined with radiotherapy to treat malignant body ulcers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0042] This example shows that it is made from the following traditional Chinese medicines in parts by weight:

[0043] 20 parts of Angelica dahurica; 30 parts of comfrey; 20 parts of saponins; 10 parts of frankincense; 10 parts of myrrh; 6 parts of borneol; 10 parts of blood; 30 parts of keel; .

[0044] Its preparation method: all the medicines are fully mixed, pulverized into fine powder, dried for later use, and when in use, after the wound is sterilized, an appropriate amount of dry medicine powder is evenly applied to the affected area, wrapped with air-permeable gauze, once a day.

example 2

[0046] This example shows that it is made from the following raw materials in parts by weight:

[0047] 25 parts of Angelica dahurica; 25 parts of comfrey; 20 parts of saponins; 10 parts of frankincense; 10 parts of myrrh; 3 parts of borneol; 10 parts of blood; 25 parts of keel; .

[0048] The preparation method of this example is the same as Example 1.

example 3

[0050] This example shows that it is made from the following raw materials in parts by weight:

[0051] 30 parts of Angelica dahurica; 20 parts of comfrey; 15 parts of saponins; 5 parts of frankincense; 5 parts of myrrh; 3 parts of borneol; 10 parts of dried blood; 30 parts of keel; .

[0052] The preparation method of this example is the same as Example 1.

[0053] Typical case 1,

[0054] The patient, female, 80 years old, had a malignant small round cell tumor of the buttocks skin with a small amount of ulceration. The tumor size was about 10*6cm. She had a history of diabetes. After one week of local radiotherapy, the area of ​​the ulceration increased significantly, and ulceration and pus flowed out.

[0055] At first, we strengthened local dressing changes to keep the wound dry and clean as much as possible, but it did not work. The wound continued to grow and had a foul smell. Escherichia coli was found in the culture of the wound secretion. Antibiotic treatment was g...

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PUM

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Abstract

A traditional Chinese medicine powder for external use combined with radiotherapy to treat malignant body surface ulcers, which is made of the following traditional Chinese medicines in parts by weight: 10-30 parts of Angelica dahurica; 20-40 parts of comfrey; 10-30 parts of saponins; 5-15 parts of frankincense 5-15 parts of myrrh; 3-9 parts of borneol; 5-15 parts of dried blood; 20-40 parts of keel; 10-30 parts of Bletilla striata; 3-9 parts of alum; The invention can clear away heat and detoxify, dissipate stagnation and suppress sores, dissipate without ulceration, astringe without stagnation, and have good effects of anti-inflammation, anti-tumor, promoting muscle growth and relieving pain, protecting skin and promoting wound healing. The present invention solves the current problem of lack of effective therapeutic drugs and methods for malignant body surface ulcers that cannot be healed after radiotherapy. It has quick effect, few side effects, low cost, convenience and practicality, and there are no reports of traditional Chinese medicine powders with similar uses at present.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for external use, in particular to a traditional Chinese medicine powder for external use combined with radiotherapy for treating malignant body surface ulcers. Background technique [0002] Malignant tumors close to the body surface, such as breast cancer, lymphoma, and subcutaneous metastases, tend to form ulcers, which are extremely difficult to heal, and are easily co-infected, resulting in the formation of malignant intractable body surface ulcers. [0003] The fundamental treatment for malignant surface ulcers is to kill tumors, such as local radiotherapy, which can kill most tumor tissues on the ulcer surface, thus providing the possibility for ulcer healing. However, most malignant surface ulcers that have undergone radiotherapy still cannot achieve ideal healing. The reasons are as follows: 1. Radiotherapy can cause radioactive skin damage, which may enlarge the ulcer surface and aggravat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61K9/14A61P17/02A61K31/045A61K33/06A61K35/02
CPCA61K9/0014A61K9/14A61K31/045A61K33/06A61K35/02A61K36/232A61K36/30A61K36/324A61K36/328A61K36/483A61K36/889A61K36/896A61K36/898A61K2300/00
Inventor 孟宪泽郭云良封颖璐李涛任红贤刘杰
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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