Iron-based hydroxide-degraded carbohydrate phosphate binder as well as preparation method and application thereof
A carbohydrate and phosphorus binding agent technology, applied in the direction of carbohydrate active ingredients, applications, drug combinations, etc., can solve the problems of patient side effects, low phosphorus adsorption capacity, etc.
Examples
preparation example Construction
[0102] A kind of preparation method of preferred phosphorus binding agent is as follows:
[0103] Mix the hydrolyzate and iron salt in water, heat, react for 1 to 240 hours, and the reaction temperature is 20 to 100 degrees Celsius; then cool to 0 to 40 degrees Celsius, add alkali until precipitation occurs, and adjust the pH of the system to 6 to 13, preferably 7 to 10; the precipitate was separated to obtain the product.
[0104] The preparation method of another kind of preferred phosphorus binder is as follows:
[0105] Mix the hydrolyzate and alkali in water, the solution temperature is 30 to 100 degrees Celsius; then add iron salt and alkali dropwise at the same time, control the pH of the system between 5 and 12, preferably 7 to 9; continue to stir for 1-24 hours; cool Bring to room temperature, add 1-10 times of ethanol, separate the precipitate, and obtain the product.
[0106] In the present invention, the iron salt is not particularly limited, and a preferred iron...
Embodiment 1
[0134] experimental method:
[0135] Dissolve 100g of gum arabic in 1000g of water, add concentrated sulfuric acid dropwise to adjust the pH of the system to 1, heat to 80°C, keep the temperature, and stir for 4 hours; add 25g of sodium citrate, raise the temperature to 90°C, and stir to fully dissolve; Add 20% by mass ferric chloride hexahydrate aqueous solution dropwise to the solution at a temperature of 90°C, and simultaneously add 20% by mass NaOH aqueous solution dropwise to control the pH of the reaction solution to be 8.0-9.0 until there is obvious precipitation and stop Add dropwise, and stir at 90°C for 5 hours to obtain a reddish-brown solution; after cooling to room temperature, centrifuge to remove the solids in the solution, add 4 times the volume of 95% ethanol to the supernatant, centrifuge after the precipitation is complete, and use Wash the solid twice with 70% ethanol and 80% ethanol; the resulting product was spray-dried to obtain a total of 145.6 g of the...
Embodiment 2
[0139] experimental method:
[0140] Dissolve 10g gum arabic in 100g water, add concentrated hydrochloric acid dropwise to adjust the pH value of the system to 1, heat to 70°C, keep the temperature, stir for 20 hours, and add 20% mass ratio of hexahydrate chloride to the solution dropwise at 70°C 150ml of iron aqueous solution, continue to stir for 4 hours after the dropwise addition, and then cool down to room temperature; dropwise add 20% NaOH aqueous solution by mass ratio, adjust the pH of the system to 8.0, and a large amount of precipitation precipitates; centrifuge to separate the precipitate, wash the precipitate with water 3 times, and the obtained product After drying, the product was 4.5 g in total, and the product was reddish brown.
[0141] Experimental results:
[0142] After hydrolysis for 20 hours, the number-average molecular weight of the gum arabic was 64,000. After the product was ground and pulverized, the iron content was 31.5% by the above-mentioned gen...
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Abstract
Description
Claims
Application Information
- IPC
- A61K33/26; A61P3/00; A61P3/12; A61P5/16; A61P3/14; A61P9/00; A61P19/00; A23L33/00; A61K31/70; A61K31/715; A61K31/736; A61K31/191
- CPC
- A23V2002/00; A61K31/191; A61K31/70; A61K31/715; A61K31/736; A61K33/26; A61K2300/00; A23V2200/30
- Inventors
- 梁星; 崔洋洋