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Delivery device of embolic protection device in blood vessel

A delivery device and protector technology, which is applied in the field of medical devices, can solve the problems of blocking blood flow, difficult surgical operation, scratching the blood vessel wall, etc., achieve rapid delivery and recovery, ensure remote blood flow, and ensure stable blood flow Effect

Pending Publication Date: 2017-12-08
北京赛铂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing distal protection devices are mainly divided into two categories: one is the distal balloon protection device, which is a guide wire with a balloon in the front section, which is opened during the operation to prevent blocky solids from slipping away, but this The technical disadvantage is that it blocks the blood flow and affects the blood supply to the distal tissue. If the operation takes a long time, it will cause ischemic necrosis of the distal cells; Accunet protectors and EmboShield protectors, Angioguard protectors from Cordis, Filterwire protectors from Boston, Aether remote protectors laser-cut by Shanghai Minimally Invasive Co. It also allows the passage of blood flow, so this type of remote protection device is also widely used in clinical
[0004] However, there are still many problems in the remote filter protection device that are worthy of people's consideration. During the process from its production to implantation in the human body, the more common phenomena include: when the product is thermally processed and finalized, and when the device is pressed into the sheath, local large Microstructural cracks caused by strain will eventually lead to structural breakage; self-expanding release, failure of the distal protection device to fully release or the stent part forcibly stretching the blood vessel, tearing and scratching the vessel wall; when capturing thrombus, due to blood flow and thrombus The position of the remote protection device is shifted due to the impact, etc., and the guide wire and the protector are incarcerated during the process of transporting the protector, etc., which leads to the entanglement of the ordinary guide wire that plays a guiding role and the protector, thus destroying the protective device. The quality of the protective device brings certain difficulties to the entire surgical operation. In addition, the existing protectors have poor adhesion to the blood vessels, which greatly stimulate the blood vessels and easily damage the blood vessel walls.

Method used

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  • Delivery device of embolic protection device in blood vessel
  • Delivery device of embolic protection device in blood vessel
  • Delivery device of embolic protection device in blood vessel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The mesh diameter on the metal mesh basket body is 700 μm.

[0070] (1) Dissolve Pellethane2363 series 80AE aromatic polyurethane in tetrahydrofuran, add 60 μm ammonium carbonate pore-forming agent, and stir well to form a pre-coating solution; the mass-volume ratio of Pellethane2363 series 80AE aromatic polyurethane to tetrahydrofuran is 0.02g / mL ; The mass ratio of ammonium carbonate and Pellethane2363 series 80AE aromatic polyurethane is 1:5;

[0071] (2) degassing the pre-coating solution in step (1) under nitrogen conditions with ultrasonic waves, the frequency of the ultrasonic wave is 80KHz, the temperature of the degassing treatment is 25°C, and the time is 5h to obtain the coating solution;

[0072] (3) Dip-coat the coating solution in step (2) on the entire distal end of the wire mesh basket body by dip-coating method under nitrogen gas, and dry at 25°C for 10 min under nitrogen gas for each dip-coating. After dipping for the first time and drying, the metal ...

Embodiment 2

[0077] The mesh diameter on the metal mesh basket body is 800 μm.

[0078] (1) Dissolve Pellethane2363 series 80AE aromatic polyurethane in chloroform, and add 120 μm of ammonium chloride pore-forming agent, stir well to form a pre-coating solution; the mass-volume ratio of Pellethane2363 series 80AE aromatic polyurethane to chloroform 0.001g / mL; the mass ratio of ammonium chloride to Pellethane2363 series 80AE aromatic polyurethane is 1:10;

[0079] (2) degassing the pre-coating solution in step (1) under nitrogen conditions with ultrasonic waves, the frequency of the ultrasonic wave is 100KHz, the temperature of the degassing treatment is 30°C, and the time is 8h to obtain the coating solution;

[0080] (3) Dip-coat the coating solution in step (2) on the entire distal end of the wire mesh basket body by dip-coating under nitrogen, and dry it at 30°C for 15 min under nitrogen for each dip-coating. After dipping for the first time and drying, the metal net blue body with coa...

Embodiment 3

[0085] The mesh diameter on the metal mesh basket body is 900 μm.

[0086] (1) Dissolve Pellethane2363 series 80AE aromatic polyurethane in methanol, add 70 μm polyethylene glycol pore-forming agent, and stir evenly to form a pre-coating solution; the mass-volume ratio of Pellethane2363 series 80AE aromatic polyurethane to methanol is 0.08g / mL; The mass ratio of polyethylene glycol to Pellethane2363 series 80AE aromatic polyurethane is 1:20;

[0087] (2) Degas the pre-coating liquid in step (1) under nitrogen condition with ultrasonic wave, the frequency of ultrasonic wave is 120KHz, the temperature of degassing treatment is 25°C, and the time is 7h, to obtain the coating liquid;

[0088] (3) Dip-coat the coating solution in step (2) on the entire distal end of the wire mesh basket body by dip-coating under nitrogen, and dry it at 30°C for 15 min under nitrogen for each dip-coating. After dipping for the first time and drying, the metal net blue body with coating is obtained...

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Abstract

The invention belongs to the field of medical instruments, and discloses a delivery device of an embolic protection device in the blood vessel. The delivery device comprises the blood vessel embolic protection device, a sheath tube and a push assembly, wherein a partition layer is arranged in the sheath tube and arranged in the axial direction of the sheath tube and partitions the inner cavity of the sheath tube into a first cavity and a second cavity adjacent to the first cavity, and the first cavity is used for containing the retracted blood vessel embolic protection device; the push assembly comprises a push rod and a protection device guide wire connected with the far end of the push rod, the far end of the protection device guide wire is connected with the near end of the blood vessel embolic protection device, and the push assembly is used for pushing out the blood vessel embolic protection device contained in the first cavity of the sheath tube from the far end of the sheath tube. When used in cerebral vein interventional angioplasty, the delivery device can intercept thrombi with the size of 0.05 mm or above and guarantee that broken thrombi will not drift or cause embolism again.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and mainly relates to a delivery device for a distal end protector in a blood vessel. Background technique [0002] The distal protector (Embolic protection device) is mainly used in carotid artery stent interventional surgery (CAS) to collect plaque in the distal vessel of the lesion (intracranial internal carotid artery) to prevent distal cerebral vascular embolism. The technical problem to be solved by the distal protector is to collect solid particles, allow blood to flow through, and maintain blood flow during interventional operations. It is usually suitable for interventional procedures such as stent placement and balloon catheter expansion to prevent Particles such as plaque falling from the vessel wall during the intervention flow within the vessel, thereby avoiding the risk of thrombus formation. [0003] Existing distal protection devices are mainly divided into two categories...

Claims

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Application Information

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IPC IPC(8): A61B17/12A61B17/22A61L31/10A61L31/14
CPCA61L31/10A61L31/146A61B17/12109A61B17/221A61B2017/2212A61B2017/22038A61B2017/22001A61B2017/1205A61B2017/00778A61B2017/00831A61B2017/00867A61L2420/02C08L75/04
Inventor 吉训明范德增
Owner 北京赛铂医药科技有限公司
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