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Traditional Chinese medicinal composition having functions of clearing away heat and toxic materials and diminishing inflammation and preparation method of traditional Chinese medicinal composition

A composition and drug technology, which is applied in the field of medicine, can solve problems such as poor product quality controllability and unreasonable production process, and achieve the effects of enhancing quality controllability, improving product curative effect, and drug efficacy

Inactive Publication Date: 2017-12-08
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems existing in the existing technology such as unreasonable production process, poor controllability of product quality and need for further improvement of curative effect

Method used

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  • Traditional Chinese medicinal composition having functions of clearing away heat and toxic materials and diminishing inflammation and preparation method of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition having functions of clearing away heat and toxic materials and diminishing inflammation and preparation method of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition having functions of clearing away heat and toxic materials and diminishing inflammation and preparation method of traditional Chinese medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] prescription

[0043] Bupleurum 250g, skullcap 125g, kudzu root 125g, buffalo horn 62.5g, honeysuckle 187.5g, isatidis 250g, forsythia 150g and rhubarb 62.5g

[0044]Preparation

[0045] 1) Ultrasonic-assisted hydrolysis of buffalo horn in a solution of 8 times the weight ratio, the hydrolysis time is 1h, and the obtained extract is ultrafiltered and dried by a 30KD molecular weight ultrafiltration device to obtain the buffalo horn extract, which is substance A;

[0046] 2) The B is prepared according to the method comprising the following steps:

[0047] Soak Banlangen, Bupleurum, Honeysuckle, and Forsythia in 8 times the amount of water for 220 minutes; distill and extract at 98°C for 2 hours, distill and extract twice to obtain distillate, collect the distillate to obtain volatile oil and medicinal residue For standby, the volatile oil of Radix Isatidis, Bupleurum, Honeysuckle, and Forsythia is clathrated with cyclodextrin, and dried to obtain Substance B;

[0048...

Embodiment 2

[0052] prescription

[0053] Bupleurum 250g, skullcap 125g, kudzu root 125g, buffalo horn 62.5g, honeysuckle 187.5g, isatidis 250g, forsythia 150g and rhubarb 62.5g

[0054] Preparation

[0055] 1) Ultrasonic-assisted hydrolysis of buffalo horn in a hydrochloric acid solution with a concentration of 0.2 mol / L at 5 times the concentration, the hydrolysis time is 6 hours, the obtained extract is ultrafiltered by a 30KD molecular weight ultrafiltration device to obtain the filtrate and dried to obtain the buffalo horn extract, which is the substance a.

[0056] 2) Soak Radix Isatidis, Bupleurum, Honeysuckle, and Forsythia in water for 10 minutes with 6 times the amount of water by weight, distill and extract volatile oil for 6 hours, and distill and extract 3 times at a distillation temperature of 90°C to obtain a distillate and collect the distillate , that is to obtain the volatile oil of Radix Radix, Bupleurum, Honeysuckle, Forsythia, and the dregs for later use; the ratio o...

Embodiment 3

[0061] prescription

[0062] Bupleurum 250g, skullcap 125g, kudzu root 125g, buffalo horn 62.5g, honeysuckle 187.5g, isatidis 250g, forsythia 150g and rhubarb 62.5g

[0063] Preparation

[0064] 1) Ultrasonic-assisted hydrolysis of buffalo horn in a protease solution with an 8-fold concentration of 200U / g. The hydrolysis time is 6 hours. The obtained extract is ultrafiltered by a 40KD molecular weight ultrafiltration device to obtain the filtrate and dried to obtain the buffalo horn extract, which is Substance A .

[0065] 2) Soak Radix Isatidis, Bupleuri, Honeysuckle, and Forsythia in water for 30 minutes with 8 times the amount of water by weight, distill to extract volatile oil for 3 hours, distill and extract twice, and distill at 100°C to obtain distillate and collect distillate , that is to obtain the volatile oil of Radix Radix, Bupleurum, Honeysuckle, and Forsythia, and the dregs for future use; the ratio of volatile oil to cyclodextrin of Radix Radix, Bupleurum, Hon...

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Abstract

The invention provides a traditional Chinese medicine, and in particular a traditional Chinese medicinal composition having functions of clearing away heat and toxic materials and diminishing inflammation and preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition consists of baicalin, baicalin, chlorogenic acid, rheum emodin and forsythin, and further consists of total volatile oil and total amino acid. The traditional Chinese medicinal composition is prepared by processing the following raw materials: radix bupleuri, radix scutellariae, radix puerariae, cornu bubali, honeysuckle flowers, radix isatidis, fructus forsythiae and radix et rhizoma rhei. The invention also provides the preparation method of the traditional Chinese medicinal composition. With the application of the composition provided by the invention, quality standard of the finished product (the composition) is improved and quality controllability is enhanced; and meanwhile, the content of active substances in the product is increased and the curative effect of the product is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Exogenous fever is one of the most common clinical symptoms in children, with fever, nasal congestion, runny nose, sneezing, and throat irritation as the main clinical manifestations. It is caused by children suffering from wind-heat and wind-cold evil, accompanied by nasal congestion, runny nose, delayed discomfort, fatigue, headache, joint pain and cough. The theory of traditional Chinese medicine believes that children have a body of immature yin and yang, with soft skin, weak lung and defense functions, low immunity, and are easily attacked by wind and pathogenic factors; they are prone to cold and heat, and they change rapidly. is the main cause of fever. The heresy of wind-heat and wind-cold, the external muscle surface, internally invades the disease of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/634A61K36/708A61K47/69A61P29/00A61K31/352A61K31/216A61K31/122A61K35/32
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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