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Method for preparing microporous polysaccharide drug-carrying microspheres

A technology of drug-loading microspheres and polysaccharides, which is applied in microcapsules, nanocapsules, drug combinations, etc., to achieve the effects of good biocompatibility, reduction of environmental pollution, and enhancement of transmembrane ability

Inactive Publication Date: 2017-12-12
史跃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the preparation and functional modification of polysaccharide drug-loaded microspheres has gradually become a focus of attention, but the preparation of polymer polysaccharide drug-loaded microspheres from plant starch has not been reported in the relevant literature.

Method used

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  • Method for preparing microporous polysaccharide drug-carrying microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Select high-quality potato starch: mix the potato plant starch with 75% ethanol in a ratio of 1:2-5 times after removing the vegetable protein, and fully stir at 50-100 rpm for 30-60 minutes to form an emulsion, and let it stand After 24 hours, ethanol was removed, and then washed with water. Add 3-5 times of purified water, keep stirring, let stand to separate layers, discard the supernatant, and then repeatedly wash the lower emulsion 3-5 times.

[0032] 2. Emulsification: The inactivated and virus-removed starch emulsion is prepared into 12-20% wet starch and added to the extrusion extruder. The starch is rubbed and extruded by the screw shaft to generate heat and gelatinized, and then passed through the pore size 3- High-pressure extrusion with small holes of 8 mm, repeated 2-10 times, to obtain pasty primary emulsified starch, emulsification temperature 120-160 ° C.

[0033] 3. Enzymatic hydrolysis and cross-linking: Cool the above-mentioned preliminary emulsif...

Embodiment 2

[0041] 1. Select high-quality potato starch: mix the potato plant starch with 75% ethanol in a ratio of 1:2-5 times after removing the vegetable protein, and fully stir at 50-100 rpm for 30-60 minutes to form an emulsion, and let it stand After 24 hours, ethanol was removed, and then washed with water. Add 3-5 times of purified water, keep stirring, let stand to separate layers, discard the supernatant, and then repeatedly wash the lower emulsion 3-5 times.

[0042] 2. Emulsification: The inactivated and virus-removed starch emulsion is prepared into 12-20% wet starch and added to the extrusion extruder. The starch is rubbed and extruded by the screw shaft to generate heat and gelatinized, and then passed through the pore size 3- High-pressure extrusion with small holes of 8 mm, repeated 2-10 times, to obtain pasty primary emulsified starch, emulsification temperature 120-160 ° C.

[0043] 3. Enzymatic hydrolysis and cross-linking: Cool the above-mentioned preliminary emulsif...

Embodiment 3

[0050] 1. Select high-quality potato starch: mix the potato plant starch with 75% ethanol in a ratio of 1:2-5 times after removing the vegetable protein, and fully stir at 50-100 rpm for 30-60 minutes to form an emulsion, and let it stand After 24 hours, ethanol was removed, and then washed with water. Add 3-5 times of purified water, keep stirring, let stand to separate layers, discard the supernatant, and then repeatedly wash the lower emulsion 3-5 times.

[0051] 2. Emulsification: The inactivated and virus-removed starch emulsion is prepared into 12-20% wet starch and added to the extrusion extruder. The starch is rubbed and extruded by the screw shaft to generate heat and gelatinized, and then passed through the pore size 3- High-pressure extrusion with small holes of 8 mm, repeated 2-10 times, to obtain pasty primary emulsified starch, emulsification temperature 120-160 ° C.

[0052] 3. Enzymatic hydrolysis and cross-linking: Cool the above-mentioned preliminary emulsif...

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Abstract

The invention discloses a method for preparing microporous polysaccharide drug-carrying microspheres. The method comprises the steps of conducting sterilization, emulsification, enzymolysis, crosslinking, washing, decoloration, hydrothermal carbonizing and screening on plant starch to obtain drug-carrying microspheres, and preparing drug-carrying microspheres with different degradation and absorption durations and different diameters according to different carbonization durations, so as to make the drug-carrying microspheres matched with drugs with different half-life periods and make drug metabolism synchronized with microsphere degradation. The prepared microporous polysaccharide drug-carrying microspheres have the advantage of being capable of prolonging the releasing, absorbing and metabolizing time of drugs in the body, so as to enhance the therapeutic effect of drugs.

Description

technical field [0001] The invention relates to a preparation method of drug-loaded microspheres, in particular to a preparation method of microporous polysaccharide drug-loaded microspheres. Background technique [0002] Domestic and foreign products that use drug-loaded microspheres to treat benign and malignant solid tumors include: polyvinyl alcohol microspheres (DC Bead) from BTG in the UK, and polymer copolymer sodium vinyl alcohol acrylate microspheres (HepaSphere) from Meriton in the United States And the polyvinyl alcohol microspheres (CalliSphere) produced by Lianyungang Hengrui Pharmaceutical that have just been listed in China. Characteristics of the three drug-loaded microspheres After the drug is slowly released and metabolized, the microspheres form a permanent embolism in the solid tumor. It has been reported in the literature that patients with uterine fibroids were embolized with the above embolization microspheres, and particles or microspheres were fou...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/51A61P35/00
CPCA61K9/5161
Inventor 史跃史峰屹
Owner 史跃
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