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Packaging product and packaging method of degradable aliphatic polyester or its medical products

A technology for degrading fat and packaging method, applied in the medical field, can solve problems such as affecting the performance of degradable aliphatic polyester raw materials and their products, large hydrolysis of raw materials in melt processing, difficulty in ensuring the stability of raw materials, etc. Risk, reduce the risk of failure, easy to operate effect

Active Publication Date: 2020-09-11
BEIJING EHANRI MEDICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, moisture will cause severe hydrolysis of degradable aliphatic polyester raw materials during melt processing; on the other hand, moisture will cause hydrolysis of degradable aliphatic polyester raw materials and their products during storage at room temperature, thus affecting the degradable Properties of Aliphatic Polyester Raw Materials and Its Products
[0004] The inventors of the present invention have discovered during the long-term research and development that, on the one hand, the degradable aliphatic polyester raw materials generally need to be pre-dried at a higher temperature. This drying process may cause the raw materials to stick together, and the moisture content inside the raw materials may decrease As high as 2000-5000ppm, which will lead to greater hydrolysis during the later melting process of raw materials; on the other hand, during the storage of degradable aliphatic polyester raw materials and their products, vacuum packaging in aluminum foil bags or nitrogen-filled packaging is generally used , due to the extremely weak air permeability of aluminum foil bags, it is difficult to ensure the stability of raw materials

Method used

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  • Packaging product and packaging method of degradable aliphatic polyester or its medical products
  • Packaging product and packaging method of degradable aliphatic polyester or its medical products
  • Packaging product and packaging method of degradable aliphatic polyester or its medical products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]300g of degradable aliphatic polyester raw material and 4A molecular sieve of a certain quality are placed in a 4-layer composite aluminum foil bag (PET / AL / PA / PE) and packaged under normal pressure, and the thickness of the aluminum foil layer is 20 microns; wherein, in embodiment 1, simultaneously Compare the drying effects of the following five degradable aliphatic polyester raw materials: A, L-lactide, glycolide copolymer 8218 (the molar ratio of L-lactide and glycolide is 82:18, referred to as PLGA8218, below Same); B, L-lactide, glycolide copolymer 6040 (PLGA6040); C, L-lactide, trimethylene carbonate lactone copolymer 7030 (PLTMC7030); D, polyglycolide (PGA ); E, L-polylactide (PLLA); the above five degradable aliphatic polyester raw materials are pellets with a diameter of 3±2mm; the above-mentioned packaged products are placed in a relatively closed plastic box at room temperature (25°C) Preserve; after a period of time, measure the moisture content in the packag...

Embodiment 2

[0028] The difference between Example 2 and Example 1 is that 4A molecular sieve is replaced by 3A molecular sieve.

Embodiment 3

[0030] The difference between Example 3 and Example 1 is that the 4A molecular sieve is replaced by BASF KC Trockenperlen silica gel desiccant.

[0031] The test result of table 2 embodiment 1-3 degradable aliphatic polyester raw material

[0032]

[0033]

[0034] As can be seen from Table 2, compared with no desiccant, the water content in the packaged product after adding a desiccant is low; after packaging the same degradable aliphatic polyester with the same desiccant, The greater the amount or the longer the packaging drying / storage time, the lower the moisture content in the packaging product, that is, the better the drying effect, and after 7 days of packaging drying / storage, the moisture content has met the requirements (less than 500ppm); from degradable Comparing the initial intrinsic viscosity of the aliphatic polyester raw material and the intrinsic viscosity after 180 days, it can be seen that the intrinsic viscosity values ​​of the two are equivalent, and ...

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Abstract

The invention discloses a packaging product and a packaging method for degradable aliphatic polyester or a medical product thereof. The packaging product comprises an airtight packaging material, and the degradable aliphatic polyester or the medical product thereof and drying agents which are placed in the airtight packaging material, wherein the dew point of a gas in the airtight packaging material is lower than -30 DEG C by the types and / or the numbers of the drying agents. In the mode, the implementation mode provided by the invention can control the content of water in the degradable aliphatic polyester or the medical product thereof in a drying process and / or a storage process.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a packaging product and a packaging method of degradable aliphatic polyester or its medical products. Background technique [0002] Medical degradable aliphatic polyester has good biocompatibility and degradability, and is widely used in absorbable sutures, internal fixation devices for fractures, tissue repair, plastic surgery, anti-tissue adhesion, drug sustained release, tissue engineering and other fields . [0003] Since the structure of such materials contains ester bonds, and ester bonds are prone to hydrolysis, moisture has an important impact on the processing and storage of degradable aliphatic polyester raw materials and their medical products. On the one hand, moisture will cause severe hydrolysis of degradable aliphatic polyester raw materials during melt processing; on the other hand, moisture will cause hydrolysis of degradable aliphatic polyester raw materials a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B65D65/38B65D81/26C08L67/04
CPCB65D65/38B65D81/26C08L67/04C08L2201/06Y02W90/10
Inventor 潘高峰高建丰缪忠尉
Owner BEIJING EHANRI MEDICAL TECH CO LTD
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