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Compound composition for prevention or treatment of diabetic eye diseases, preparation method and use thereof

A technology for diabetic ophthalmopathy and a composition, applied in the field of traditional Chinese medicine, can solve problems such as blindness, and achieve the effects of convenient administration, good effect, and cheap and easy-to-obtain raw materials

Active Publication Date: 2018-01-16
THE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without timely diagnosis and reasonable treatment, it may eventually lead to blindness
At present, there is no effective and convenient drug to treat this pathological change.

Method used

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  • Compound composition for prevention or treatment of diabetic eye diseases, preparation method and use thereof
  • Compound composition for prevention or treatment of diabetic eye diseases, preparation method and use thereof
  • Compound composition for prevention or treatment of diabetic eye diseases, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation of embodiment 1 Chinese medicine compound composition

[0051] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 10 times the total weight of the medicinal materials, and decoct twice for 60 minutes each time, filter, combine the filtrates and concentrate to dryness to obtain 25 g of Coptis chinensis total extract.

[0052] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and berberine and other berberine alkaloid compounds, the alkaloid compound accounted for 45% by weight of the total extract of Coptis chinensis.

[0053] The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 26%.

[0054] Using the phenol-sulfuric acid colorimetric method (see Example...

Embodiment 2

[0057] The preparation of embodiment 2 Chinese medicine compound composition

[0058] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 20 times the total weight of the medicinal materials and decoct 3 times for 120 minutes each time, filter, combine the filtrates and concentrate until dry to obtain 40 g of Coptis chinensis total extract.

[0059] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and berberine alkaloid compounds such as berberine, the alkaloid compound accounted for 60% by weight of the total extract of Coptis chinensis.

[0060] The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 38%.

[0061] Using the phenol-sulfuric acid colorimetric method, it is measur...

Embodiment 3

[0064] The preparation of embodiment 3 Chinese medicine compound composition

[0065] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 15 times the total weight of the medicinal materials and decoct once for 90 minutes, filter, and concentrate the filtrate to dryness to obtain 15 g of Coptis chinensis total extract.

[0066] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and alkaloid compounds such as berberine, the alkaloid compound accounts for 31% by weight of the total extract of Coptis chinensis. The weight percentage of the polysaccharide component in the total extract of Coptis chinensis is 19%. The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 19%.

[0067] (2...

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Abstract

The invention provides a Chinese herbal compound composition for prevention or treatment of diabetic eye diseases. The composition comprises a coptidis rhizome total extract and a rhizoma zingiberis recens extract in a weight ratio of 4:1-1:1. The invention also provides a preparation method and use of the Chinese herbal compound composition. The invention further provides use of the coptidis rhizome total extract. The Chinese herbal compound composition for prevention or treatment of diabetic eye diseases has the advantages of cheap and easily available raw materials, simple preparation method and convenient drug administration. Pharmacological research results show that the coptidis rhizome total extract involved in the invention has significantly better effect in prevention and treatment of type I and type II diabetic eye diseases than a coptidis rhizome total alksloid mixture. And through combined use of the coptidis rhizome total extract and the rhizoma zingiberis recens extract,the Chinese herbal compound composition provided by the invention also has further remarkably improved effect in prevention and treatment of type I and type II diabetic eye diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. Specifically, the present invention relates to a compound traditional Chinese medicine composition for preventing or treating diabetic eye disease. The invention also relates to the preparation method and application of the traditional Chinese medicine compound composition, as well as the application of the total extract of Coptis chinensis. Background technique [0002] With the improvement of people's living standards, nutritional structure changes. Obesity and other metabolic diseases are gradually increasing, and the accompanying incidence of type II diabetes is getting higher and higher. At the same time, irregular living habits, fatigue, excessive smoking and drinking, and changes in environmental factors lead to changes in the human immune system and genetic structure, resulting in an increase in the number of cases of type I diabetes dominated by genetic factors. Research on...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P3/10A61P9/10
Inventor 冯奕斌王宁
Owner THE UNIVERSITY OF HONG KONG
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