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Hydroxyapatite ultra-long nano-wire/collagen composite porous biological scaffold and application thereof

A hydroxyapatite and biological scaffold technology, which is applied in other chemical processes, separation methods, prostheses, etc., can solve the problems of poor mechanical strength, low hydroxyapatite content, and unsatisfactory degradability, and achieve high flexibility. The effect of improving mechanical strength and excellent mechanical properties

Inactive Publication Date: 2018-01-30
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the diameter of the hydroxyapatite whiskers used is on the micron scale, and its degradability is not ideal
[0009] Although the current literature has reported methods for preparing hydroxyapatite / collagen composite porous bioscaffolds with enhanced mechanical properties, the prepared hydroxyapatite / collagen composite porous bioscaffolds generally have poor mechanical strength and three-dimensional through-porous structures. Not obvious, low hydroxyapatite content and other disadvantages

Method used

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  • Hydroxyapatite ultra-long nano-wire/collagen composite porous biological scaffold and application thereof
  • Hydroxyapatite ultra-long nano-wire/collagen composite porous biological scaffold and application thereof
  • Hydroxyapatite ultra-long nano-wire/collagen composite porous biological scaffold and application thereof

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preparation example Construction

[0038] Preparation of ultralong nanowires from hydroxyapatite. The hydroxyapatite ultra-long nanowires of the present invention can be prepared by the solvothermal method of the calcium oleate precursor, can it be prepared by referring to the methods reported in the literature and patents; for example: Zhu Yingjie, Lu Bingqiang, Chen Feng, high flexibility High temperature resistant non-combustible hydroxyapatite paper and its preparation method, patent number ZL201310687363.2; Ying-Ying Jiang, Ying-Jie Zhu, Feng Chen, Jin Wu, Ceramics International, 41(2015) 6098-6102; Yong-Gang Zhang, Ying-Jie Zhu Feng Chen, Jin Wu, Materials Letters, 144 (2015) 135-137. Other suitable preparation methods can also be used, as long as the method can be used to prepare the hydroxyapatite ultra-long nanowires. The hydroxyapatite ultra-long nanowires of the present invention may have a diameter of 5-100 nanometers and a length of 20-2000 microns. The hydroxyapatite ultra-long nanowire of the p...

Embodiment 1

[0055] 2.000 grams of freeze-dried collagen sponges were dissolved in 48 grams of water, and a uniform aqueous collagen solution was obtained through stirring (collagen concentration was 0.04g g -1 , that is, each gram of collagen aqueous solution contains 0.04g collagen), and then transferred to a 24-well cell culture plate, frozen at –20°C for 24 hours, freeze-dried, and then soaked the freeze-dried collagen porous bioscaffold in a solution containing 20mM 1- Carry out chemical cross-linking in 80vol.% ethanol / 20vol.% water mixed solution of ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 8mM N-hydroxysuccinimide, cross-linking treatment After 12 hours, take it out, wash it with ethanol and water respectively, and then dry it in an oven at 37°C. The pure collagen porous biological scaffold is obtained, and the surface of the pore wall is relatively smooth. The Young's modulus of the prepared pure collagen porous bioscaffold is 15.0±2.3kPa.

Embodiment 2

[0057] 2.000 grams of freeze-dried collagen sponges were dissolved in 48 grams of water, and a uniform aqueous collagen solution was obtained through stirring (collagen concentration was 0.04g g -1 ). Disperse hydroxyapatite ultra-long nanowires in water to obtain hydroxyapatite ultra-long nanowires with a concentration of 0.04g g -1 (that is, each gram of hydroxyapatite ultra-long nanowire aqueous dispersion contains 0.04 g of hydroxyapatite ultra-long nanowire). The prepared hydroxyapatite ultra-long nanowire dispersion and collagen aqueous solution were mixed at a mass ratio of 1:3, stirred evenly by magnetic force at room temperature for 2 hours, transferred to a 24-well cell culture plate, and stored at –20°C After freezing for 24 hours, freeze-dry, and then soak the freeze-dried hydroxyapatite ultralong nanowire / collagen composite porous biological scaffold in 20mM 1-ethyl-(3-dimethylaminopropyl)carbodiazide Carry out chemical cross-linking in 80vol.% ethanol / 20vol.% w...

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Abstract

The invention relates to a hydroxyapatite ultra-long nano-wire / collagen composite porous biological scaffold and application thereof. The hydroxyapatite ultra-long nano-wire / collagen composite porousbiological scaffold is prepared by taking hydroxyapatite ultra-long nano-wires as inorganic ingredients and taking collagen as organic ingredients.

Description

technical field [0001] The invention relates to a hydroxyapatite ultra-long nanowire / collagen composite porous biological support and a preparation method and application thereof, belonging to the field of biological materials. Background technique [0002] The repair of bone defects caused by bone tumor resection, infection and trauma has always been one of the hotspots in biomedical research. Autologous bone grafting has excellent osteoinductive activity and immunocompatibility, and has always been the gold standard for clinical bone defect treatment. However, this method faces problems such as limited source of autologous bone, increased risk of infection for patients, and high incidence of postoperative complications. There are also shortcomings such as disease transmission and immune rejection for the allogeneic bone transplantation commonly used in clinical practice. Therefore, the development of synthetic bone graft materials with excellent bone defect repair ability...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/58B01J20/24B01D39/02
Inventor 朱英杰孙团伟陈峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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