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Application of 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol to comprehensive prevention and treatment of lipid abnormity and diabetes

A technology of acetoxy and quincediene, which is applied in the field of medicine, can solve the problems that have not been seen, the glucose tolerance and insulin resistance of diabetic patients have little effect, and the blood lipid level cannot be significantly adjusted.

Active Publication Date: 2018-02-09
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the process of comprehensive prevention and treatment of dyslipidemia and diabetes, the use of blood lipid-lowering drugs can effectively regulate blood lipids and help alleviate the condition of diabetes. Glucose tolerance and insulin resistance have little effect; sulfonylureas, biguanides, thiazolidinediones, α-glucosidase inhibitors, repaglinide, insulin and other hypoglycemic drugs can effectively reduce blood sugar levels, but Only thiazolidinediones can improve insulin resistance, but can not significantly regulate blood lipid levels
[0005] There is no application of 3β-acetoxy-7,25-mannadien-24R-ol in the comprehensive prevention and treatment of dyslipidemia and diabetes

Method used

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  • Application of 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol to comprehensive prevention and treatment of lipid abnormity and diabetes
  • Application of 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol to comprehensive prevention and treatment of lipid abnormity and diabetes
  • Application of 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol to comprehensive prevention and treatment of lipid abnormity and diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: The lipid-lowering effect of 3β-acetoxy-7,25-calendadien-24R-ol

[0023] 1. Experimental animals and methods

[0024] C57BL mice, SPF grade, male, body weight (20±2) g, were randomly divided into two groups, the first group of 14 was the normal control group, given normal feed, and the remaining mice (34) were used to produce high-fat mice. The models were given high-fat feed (20% lard, 1.25% cholesterol, and 0.5% sodium cholate were added to the basic feed), and they were free to eat and drink. After 8 weeks of continuous feeding, 4 mice were sacrificed from the normal control group and the model mice respectively, and the serum and liver biochemical indicators of the two groups of mice, as well as the pathological sections of liver tissue, were compared to determine whether the model was established successfully. 30 mice successfully modeled were randomly divided into 3 groups, the model group (10 mice), the 3β-acetoxy-7,25-calendadiene-24R-alcohol group (...

Embodiment 2

[0037] Example 2: Hypoglycemic Effect of 3β-Acetoxy-7,25-Calendadien-24R-ol

[0038] 1. Experimental animals and methods

[0039] The modeling and administration methods are the same as those in Example 1, and the drug is administered by gavage continuously for 6 weeks after the modeling.

[0040] Glucose tolerance test method: After 6 weeks of continuous administration, the mice were fasted overnight, and after oral administration of glucose 2g / kg at 0, 15, 30, 60, 90, and 120 minutes respectively, the blood glucose was measured at the tip of the tail, and calculated using GraphPad Prism software The corresponding area under the line (AUC).

[0041] Insulin tolerance test method: After continuous administration of mice for 6 weeks, fasting overnight, intraperitoneal injection of insulin 0.75IU / kg at 0, 30, 60, 90, 120, and 150min, the tail tip blood was taken to measure the corresponding blood sugar, using GraphPad Prism software calculates the corresponding area under the ...

Embodiment 3

[0059] Embodiment 3: the application in pharmaceutical preparation or food

[0060] 1. 3β-Acetoxy-7,25-Granadien-24R-ol Tablets

[0061] 3β-Acetoxy-7,25-calendadien-24R-ol 10mg, starch 88g, magnesium stearate 3g.

[0062] Preparation process: Take 3β-acetoxy-7,25-camadien-24R-alcohol, mix with starch and magnesium stearate evenly, make granules, dry, and compress into tablets.

[0063] 2. 3β-Acetoxy-7,25-Candrene-24R-ol Capsules

[0064] 3β-Acetoxy-7,25-calendadien-24R-ol 10mg, starch 88g, magnesium stearate 3g.

[0065] Preparation process: Take 3β-acetoxy-7,25-camadien-24R-alcohol, mix with starch and magnesium stearate evenly, make granules, dry, pack into capsules, and obtain.

[0066] 3. 3β-Acetoxy-7,25-Mansadien-24R-ol Injection

[0067] 3β-Acetoxy-7,25-calendadien-24R-ol 47mg, sodium chloride for injection 7mg.

[0068] Preparation process: Dissolve 3β-acetoxy-7,25-camadien-24R-alcohol in 1.9 mL of water for injection, add sodium chloride for injection to isotonici...

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Abstract

The invention discloses application of 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol to comprehensive prevention and treatment of lipid abnormity and diabetes. Through discovery, the 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol can reduce the lipid (including blood fat and liver fat reduction), can also reduce the blood glucose and can improve the sugar tolerance and the insulin resistance, so that the 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol can be used for comprehensively prevent and treating the lipid abnormity and diabetes. Through discovery, the illumination stability of the 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol can be improved by auxiliary materials of magnesium stearate. Therefore, the 3 beta-acetoxyl group-7,25-kanziol diene-24R-alcohol canbe used for preparing medicine preparations or food for comprehensive preventing and treatment of lipid abnormity and diabetes.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known compounds, in particular to the application of 3β-acetoxy-7,25-camadien-24R-alcohol in the comprehensive prevention and treatment of dyslipidemia and diabetes. Background technique [0002] Diabetes is a syndrome of metabolic abnormalities caused by the interaction of genetic and environmental factors. It can cause chronic complications in multiple system organs of the whole body, and has a high rate of disability and death. With the economic development of today's society, the improvement of people's living standards, the faster pace of life, people's daily intake of high-protein and high-calorie food is too much, and people's physical labor and energy consumption are getting less and less. Dyslipidemia and obesity have become A common phenomenon that accompanies people today. Many studies have found that patients with type 2 diabetes are often combined with o...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K47/12A61P3/10A61P3/06A61P1/16A61P5/50
CPCA61K31/575A61K47/12
Inventor 谢治深王辉张振强刘佩秦燕赵振彪
Owner HENAN UNIV OF CHINESE MEDICINE