A kind of aerosol for treating chronic obstructive pulmonary disease

Abstract

The invention provides an aerosol for treating chronic obstructive pulmonary disease, which is composed of active ingredients, additives, and propellants, wherein the active ingredients are composed of three compounds: ligustilide, matrine, and peiminin in proportion. The mass ratio of the three active components is 1% to 99% for each component, and the range of the active component to the mass of the aerosol is 1 to 99%. There are two types of aerosol dosage forms: solution type and mixed type. The above-mentioned aerosol drug, through the COPD animal model, has proved that it has various effects such as inhibiting the secretion of relevant inflammatory factors, inhibiting the expression of mucus hypersecretion-related proteins, and inhibiting epithelial cell apoptosis and necrosis. It can directly reach the affected area and has a quick effect. The curative effect is good, the animal experiment proves that it has good anti-COPD effect, and can be applied in the preparation of medicines for treating chronic obstructive pulmonary disease.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an aerosol for treating chronic obstructive pulmonary disease (COPD). aerosol. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by airflow limitation that is not fully reversible and is the result of a combination of small airway disease (bronchiolitis obliterans) and destruction of the lung parenchyma (emphysema) . COPD is one of the major diseases that seriously endanger public health in the world. According to the forecast of WHO, COPD will become the third leading cause of death in the world after cardiovascular and cerebrovascular diseases and tumors by 2030. In 2007, a survey of 20,245 adults in 7 regions in my country showed that the prevalence of COPD was as high as 8.2% among people over 40 years old. COPD not only has a high prevalence rate, but also develops progressively in the course of the disease, which can caus...

AI Technical Summary

Problems solved by technology

3. Antibiotics: According to the research support of the past 10 years, infection is a major factor in COPD. The use of antibiotics can control inflammation, but repeated use can easily lead to drug resistance

Generally speaking, these drugs have limited therapeutic effects and many side effects, which have little effect on preventing its progression and disease exacerbation

Images