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Preparation method of tea-oil tree fruit shell anti-enteritis micro-capsule and product and application thereof

A technology of Camellia oleifera husk and enteritis, which is applied in the field of medicine, can solve problems such as no related reports, and achieve the effects of simple preparation process, convenient industrial production, and enhanced drug effect

Active Publication Date: 2018-02-09
GANNAN MEDICAL UNIV +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant report on the application of extracting tannin from Camellia oleifera husk and making it into anti-enteritis microcapsule preparation

Method used

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  • Preparation method of tea-oil tree fruit shell anti-enteritis micro-capsule and product and application thereof
  • Preparation method of tea-oil tree fruit shell anti-enteritis micro-capsule and product and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of camellia oleifera husk anti-enteritis microcapsules, the steps are:

[0024] A. Add 1 kg of Camellia oleifera husk to 0.5 kg of 85% (V / V) ethanol aqueous solution, 500W ultrasonic treatment at room temperature for 1 h, filter, and the filtrate is adsorbed for 24 h through 0.5 kg of D101 macroporous resin, and washed with 65% (V / V) ) was eluted with an ethanol aqueous solution, and dried under reduced pressure at 0.01 MPa at 50°C for 3 hours to obtain 110 g of tannin in camellia oleifera husk;

[0025] B. Add 5g of tea tree oil, 5g oregano oil, 500g of 10% (g / mL) acrylic resin II and acrylic resin III mixed acetone solution in 100g Camellia oleifera husk tannin, the mixture of acrylic resin II and acrylic resin III The mass ratio is 1:1, stirred at 800 rpm for 90 min, then dropped into liquid paraffin whose volume is 3 times the system volume, and stirred at 800 rpm for 90 min;

[0026] C. Stand for stratification, remove the liquid layer, rins...

Embodiment 2

[0028] The preparation method of camellia oleifera husk anti-enteritis microcapsules, the steps are:

[0029] A. Add 1kg camellia oleifera husk to 3kg of 50% (V / V) ethanol aqueous solution, 50W ultrasonic treatment at room temperature for 5h, filter, the filtrate is absorbed by 2kg of HPD100 macroporous resin for 8h, and use 40% (V / V) Eluted with aqueous ethanol solution, dried under reduced pressure at 0.1 MPa at 65°C for 4 hours, and obtained 165 g of tannin in camellia oleifera husk;

[0030] B. Add 1g tea tree oil, 1g oregano oil, 1000g 3% (g / mL) acrylic resin II and acrylic resin III mixed acetone solution to 100g Camellia oleifera husk tannin, the mixture of acrylic resin II and acrylic resin III The mass ratio is 2:1, stirred at 1000 rpm for 30 min, then dropped into liquid paraffin whose volume is 1 times the system volume, and stirred at 1000 rpm for 30 min;

[0031] C. Stand for stratification, remove the liquid layer, rinse the solid with 3 times the mass of n-hexa...

Embodiment 3

[0033] The preparation method of camellia oleifera husk anti-enteritis microcapsules, the steps are:

[0034] A. Add 1 kg of 60% (V / V) ethanol aqueous solution to 1 kg of camellia oleifera husk, 100W ultrasonic treatment at room temperature for 3 h, filter, and the filtrate is adsorbed by 1 kg of HPD400 macroporous resin for 12 h, and treated with 50% (V / V) ethanol Eluted with aqueous ethanol, dried under reduced pressure at 0.05 MPa at 60°C for 6 hours to obtain 124 g of tannin in camellia oleifera husk;

[0035] B. Add 4g of tea tree oil, 6g oregano oil, 600g of 8% (g / mL) acrylic resin II and acrylic resin III mixed acetone solution in 100g camellia oleifera husk tannin, the mixture of acrylic resin II and acrylic resin III The mass ratio is 3:1, stirred at 2000 rpm for 60 min, then dropped into liquid paraffin whose volume is 3 times the system volume, and stirred at 2000 rpm for 60 min;

[0036] C. Stand for stratification, remove the liquid layer, rinse the solid with 4 ...

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Abstract

The invention discloses a preparation method of tea-oil tree fruit shell anti-enteritis micro-capsule and a product and application thereof. The preparation method of the tea-oil tree fruit shell anti-enteritis micro-capsule comprises the following steps that tea-oil tree fruit shells are added into an ethanol water solution, ultrasonic treatment and filtration are performed, filtrate is absorbedthrough macro-porous resin, elution is performed with the ethanol water solution to obtain tea-oil tree fruit shell tannin, an acetone solution prepared from tea tree oil, origanum oil and acrylic resin is added into the tea-oil tree fruit shell tannin, then the tea-oil tree fruit shell tannin is dropwise added into liquid paraffin, standing and layering are performed, a liquid layer is removed, solid matter is leached with n-hexane, and air drying is performed to obtain the tea-oil tree fruit shell anti-enteritis micro-capsule. The tannin content of the tea-oil tree fruit shell anti-enteritismicro-capsule prepared by adopting the method is 45-75%, and the particle size is 0.5-5 microns. The preparation method can be used for preparing a drug preparation for preventing and treating enteritis. The tea-oil tree fruit shell anti-enteritis micro-capsule prepared by adopting the method can strengthen tannin absorption of intestinal tract cells and improve the acting effect of the drug.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method, product and application of camellia oleifera husk anti-enteritis microcapsules. Background technique [0002] Enteritis is gastroenteritis, enteritis and colitis caused by bacteria, viruses, fungi and parasites. Clinical manifestations include nausea, vomiting, abdominal pain, diarrhea, loose watery stools or mucus, pus and bloody stools and other symptoms. Enteritis is very common, with an annual incidence of about 3 to 5 billion people worldwide, especially in developing countries with high morbidity and mortality, especially children. According to the statistics of the World Health Organization, in developing countries, infectious diarrhea is the infectious disease with the highest morbidity among children, and the case fatality rate is about 20%. life. At present, the main drugs are antibiotics, and the usage ratio is as high as 50%. Antimicrobial...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K9/50A61P1/00A61P1/04A61K131/00
CPCA61K9/5026A61K36/53A61K36/61A61K36/82A61K2236/333A61K2236/53A61K2236/55A61K2300/00
Inventor 干小英叶勇彭旗刘常春范小娜刘运华刘思思何璇朱亮舒洁倩曾炜
Owner GANNAN MEDICAL UNIV
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