Antibacterial alginate hydrocolloid dressing and preparation method thereof

An antibacterial alginate and hydrocolloid technology, applied in the field of medical devices, can solve the problems of negative biological effects, unclear adverse reactions, and application limitations, and achieve beneficial healing, strong liquid absorption and moisturizing properties, and prevent bacterial invasion Effect

Inactive Publication Date: 2018-02-16
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the negative biological effects and adverse reactions caused by the migration of nano-sized silver particles into the human body are still unclear, the clinical application of this nano-silver hydrocolloid dressing is greatly limited.

Method used

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  • Antibacterial alginate hydrocolloid dressing and preparation method thereof
  • Antibacterial alginate hydrocolloid dressing and preparation method thereof
  • Antibacterial alginate hydrocolloid dressing and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0031] (1) Preparation of gelatin-modified alginate composites

[0032] Weigh a certain amount of gelatin and calcium chloride and dissolve them in distilled water at 50°C in turn to prepare a gelatin calcium chloride solution with a gelatin concentration of 20%wt and a calcium chloride concentration of 2%wt; weigh a certain amount of modified Sodium alginate and polyethylene glycol are dissolved in distilled water successively, and the polyethylene glycol modified sodium alginate solution that the concentration of polyethylene glycol is 20%wt, and the concentration of modified sodium alginate is 5%wt is prepared; Then Mix the gelatin calcium chloride solution with the polyethylene glycol modified sodium alginate solution in a volume ratio of 1:0.6-1 to obtain a gelatin modified alginate composite material;

[0033] (2) Preparation of polyvinyl alcohol antimicrobial peptide D2A21 fiber membrane

[0034] Weigh a certain amount of polyvinyl alcohol, add it to distilled water, h...

Embodiment 1

[0038] Prepare a kind of antimicrobial alginate hydrocolloid dressing by the above method according to the present invention, wherein: its molecular weight of the polyethylene glycol used in the preparation process is 5000, the polyvinyl alcohol molecular weight used is 80000, its particle diameter of used antimicrobial peptide D2A21 The distribution is 150-250 nm; the electrospinning machine used is the TL-BM-700 electrospinning machine produced by Shenzhen Tongli Micro-Nano Co., Ltd., and the spinning parameters are set as follows: high-voltage power supply voltage: 15kV, rotation speed of the rotary yarn collector : 1500rpm, output pump flow rate: 50 mL / h; in parts by weight, it consists of 10 parts of gelatin, 5 parts of modified sodium alginate, 10 parts of polyethylene glycol, 20 parts of polyvinyl alcohol and 10.05 parts of antimicrobial peptide D2A2 .

Embodiment 2

[0040]Prepare a kind of antimicrobial alginate hydrocolloid dressing by the above method according to the present invention, wherein: its molecular weight of the polyethylene glycol used in the preparation process is 5000, the polyvinyl alcohol molecular weight used is 80000, its particle diameter of used antimicrobial peptide D2A21 The distribution is 150-250 nm; the electrospinning machine used is the TL-BM-700 electrospinning machine produced by Shenzhen Tongli Micro-Nano Co., Ltd., and the spinning parameters are set as follows: high-voltage power supply voltage: 15kV, rotation speed of the rotary yarn collector : 1500rpm, output pump flow rate: 50 mL / h; in parts by weight, it consists of 20 parts of gelatin, 10 parts of modified sodium alginate, 15 parts of polyethylene glycol, 30 parts of polyvinyl alcohol and 10.075 parts of antimicrobial peptide D2A2 .

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Abstract

The invention belongs to the technical field of a medical apparatus, and discloses an antibacterial alginate hydrocolloid dressing and a preparation method thereof. The antibacterial alginate hydrocolloid dressing comprises, by weight, 10-30 parts of gelatin, 5-15 parts of modified sodium alginate, 10-20 parts of polyethylene glycol, 20-40 parts of polyvinyl alcohol and 0.05-0.1 part of antibacterial peptide D2A21. The preparation method includes preparation of a gelatin-modified alginate composite material, preparation of a polyvinyl alcohol and antibacterial peptide D2A21 fibrous membrane, and preparation of a hydrocolloid dressing. The method is simple and is low in cost. The prepared hydrocolloid dressing is great in water absorption and excellent in performance, and has good compatibility and antibacterial effect.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to an antibacterial alginate hydrogel dressing and a preparation method thereof. Background technique [0002] Medical hydrocolloid dressing is a dressing for wound care made by mixing hydrocolloid particles with rubber. The hydrocolloid dressing has both the water absorption of the hydrocolloid and the adhesiveness of the rubber substrate. After being applied to the wound, the rubber substrate makes the dressing adhere to the wound, while the hydrocolloid particles swell after absorbing water, providing a moist surface for the wound. An airtight environment that promotes wound healing. However, due to the lack of antibacterial properties of this hydrocolloid dressing, the effect is often unsatisfactory when dealing with chronic wounds, especially chronic wounds with potential infection risks or mild infections. Although some hydrocolloid dressings have added inorganic ant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/26A61L15/46
CPCA61L15/26A61L15/28A61L15/32A61L15/425A61L15/46A61L2300/252A61L2300/404C08L5/04C08L29/04C08L71/02C08L89/00
Inventor 韦加娜陈锦涛陈泰瀛
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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