Multi-trace-element V pharmaceutical composition and uses thereof

A technology of trace elements and compositions, applied in the field of medicine, can solve problems such as adverse consequences, poor patient tolerance or clinical accidents, and uncomfortable patients

Inactive Publication Date: 2018-03-13
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism
Although the physiological pH of the human body generally reaches about 7.4, the pH value in the preparation in the prior art is maintained at a very low level with sulfuric acid, and the general pH value is between 2.0 and 3.0 to prevent quality problems in the injection. Drug preparation and clinical intravenous infusion bring a certain degree of safety hazards and some adverse reactions, including vascular irritation or phlebitis, local necrosis, poor patient tolerance or clinical accidents, etc., especially once the injection is prepared Particles appear during the process or during the infusion, which is prone to accidental fatal dan...

Method used

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  • Multi-trace-element V pharmaceutical composition and uses thereof
  • Multi-trace-element V pharmaceutical composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] The preparation of embodiment 1 multiple trace element pharmaceutical composition injection

[0095] Prescription: zinc gluconate hydrate 34862mg (calculated as zinc gluconate anhydrate)

[0096]

[0097] Appropriate amount of 2M gluconic acid solution and 2M sodium citrate solution

[0098] Appropriate amount of water for injection

[0099] Add water for injection to the full volume of 1000ml

[0100] Preparation process: Weigh or prepare raw and auxiliary materials according to the prescription quantity, step 1, stir and dissolve the prescription quantity of sodium gluconate, sorbitol, taurine, and sodium pantothenate with an appropriate amount of fresh water for injection, and acidify the pH with gluconic acid solution value to 3.8; step 2, chromium chloride 6 hydrate, copper sulfate pentahydrate, and manganese sulfate 1 hydrate are respectively acidified with gluconic acid solution and fresh water for injection is stirred and dissolved, and the solution is kept...

Embodiment 2

[0102] The preparation of embodiment 2 multiple trace element pharmaceutical composition injections

[0103] Prescription: zinc gluconate trihydrate 38997mg, chromium chloride hexahydrate 51.3mg, copper sulfate pentahydrate 3930mg, manganese sulfate monohydrate 1540mg, sodium selenite 5hydrate 145mg, taurine 20g, sorbitol 50g, Sodium gluconate 10g, L-sodium pantothenate 3g, appropriate amount of 2M gluconic acid solution and 2M sodium lactate solution, appropriate amount of water for injection, add water for injection to the full amount of 1000ml

[0104] Preparation process: Weigh or prepare raw and auxiliary materials according to the prescription quantity, step 1, stir and dissolve the prescription quantity of taurine, sodium gluconate, sorbitol, and L-sodium pantothenate with an appropriate amount of fresh water for injection, acidify the pH of the gluconic acid solution value to 3.8; step 2, chromium chloride 6 hydrate, copper sulfate pentahydrate, manganese sulfate 1 hyd...

Embodiment 3

[0105] The preparation of embodiment 3 multiple trace element pharmaceutical composition injections

[0106] Prescription: Zinc gluconate trihydrate 38997.3mg, chromium chloride hexahydrate 51.3mg, copper sulfate pentahydrate 3930mg, manganese sulfate monohydrate 1540mg, sodium selenite 5hydrate 145.1mg, taurine 30g, sorbitol 20g, glycine 20g, sodium gluconate 12g, appropriate amount of 2M gluconic acid solution and 2M sodium hydroxide solution, appropriate amount of 5M sodium hydroxide solution, appropriate amount of water for injection, add water for injection to the full amount of 1000ml

[0107] Preparation process: Weigh or prepare raw and auxiliary materials according to the prescription quantity. Step 1. Stir and dissolve the prescription quantity of taurine, sorbitol, glycine, and sodium gluconate with an appropriate amount of fresh water for injection. Jointly adjust the pH value of the solution to 3.9; Step 2, stir and dissolve the water for injection acidified with ...

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Abstract

The present invention provides a new multi-trace-element pharmaceutical composition for preventing or treating the deficiency of various trace elements such as zinc, manganese, copper, chromium and selenium in humans and mammals, and syndromes thereof so as to reduce adverse reactions during treatment, such that the new multi-trace-element pharmaceutical composition has good safety, good compliance, new adaptive population and the like in the clinical process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition for injection of multiple trace elements for preventing or treating zinc, manganese, chromium, copper, selenium deficiency and syndromes thereof, as well as its preparation and application. Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with mercaptans, block mercaptans and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit fat peroxidation, stabilize cell membranes and make them more resistant to free radical attacks Therefore, zinc is of great significance not only to cell growth but also to cell protection...

Claims

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Application Information

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IPC IPC(8): A61K33/34A61P3/02A61K33/30A61K33/32A61K33/04A61K33/24
CPCA61K9/0019A61K9/08A61K33/04A61K33/24A61K33/30A61K33/32A61K33/34A61K47/26A61K2300/00
Inventor 刘力
Owner 刘力
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