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Developing carboxyl modified polyvinyl alcohol microsphere embolization agent and preparation technology thereof

A polyvinyl alcohol microsphere, carboxyl modification technology, applied in surgical adhesives, applications, medical science and other directions, can solve the problem of drug-loading and controllable drug release properties that do not reflect the value of microspheres, permanent embolism and non-degradable, There are no problems such as the formation of lipiodol, which can reduce the possibility of recanalization, good biocompatibility and degradability, and reduce iatrogenic damage.

Inactive Publication Date: 2018-03-20
杭州华微医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product is non-degradable for permanent embolism; good visibility under X-ray, easy to observe the embolism site; nuclear magnetic resonance (MRI) examination can be performed after embolization; moderate specific gravity, can be suspended in the blood, and can follow the flow of blood to the end Vascular drift, easy to deposit in blood vessels, embolism, and good positioning; but the above invention has not been industrialized, and because the invention does not reflect the maximum value of microspheres drug loading and controllable drug release, it has not formed and classic Compared with lipiodol c-TACE, it has superior characteristics, but it cannot meet the requirements of corresponding clinicians.
However, microsphere embolization in clinical applications requires drug loading, which is not reflected in the above-mentioned inventions.

Method used

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preparation example Construction

[0023] Two, the preparation method of carboxy-modified polyvinyl alcohol:

[0024] Raw material preparation:

[0025] Monomer: vinyl acetate, 0.7% maleic acid by weight of vinyl acetate is made into a maleic acid ethanol solution with a mass concentration of 10%;

[0026] Solvent: account for 20% ethanol of vinyl acetate weight;

[0027] Initiator: the azobisisobutyronitrile ethanol solution that accounts for 0.1% of the weight of vinyl acetate is made into a mass concentration of 2.0% azobisisobutyronitrile;

[0028] Preparation:

[0029] Add the vinyl acetate monomer, maleic acid ethanol solution and azobisisobutyronitrile ethanol solution prepared above into the first polymerization kettle, wherein vinyl acetate and azobisisobutyronitrile ethanol solution are all added, maleic acid ethanol The solution is added to account for 50% of the total weight of the maleic acid ethanol solution, the polymerization reaction temperature is 60 ± 5 ° C, and the time is 80 minutes; the...

Embodiment 1

[0032] The carboxy-modified polyvinyl alcohol prepared above is formulated into 500ml of a 10% solution. After fully dissolving, add a mixture of 10g of polyvinyl alcohol and 50g of metal tantalum powder (10 micron in diameter), and heat it to above 40°C and stir in a water bath. Fully dissolve. Add dropwise to 10 times the amount of liquid paraffin, stir for 20 minutes, add 5% glutaraldehyde solution 80ml, continue to stir for 60 minutes, ice bath for 30 minutes, filter, wash the solid part with absolute ethanol and water alternately for 3 times, freeze-dry, that is have to.

[0033] Microspheres with different particle sizes can be obtained by adjusting the concentration of carboxyl-modified polyvinyl alcohol solution, the ratio of added aldehyde compounds and the ratio of liquid paraffin or vegetable oil.

Embodiment 2

[0035] The carboxy-modified polyvinyl alcohol prepared above is formulated into 500ml of a 10% solution. After fully dissolving, add a mixture of 10g of polyvinyl alcohol and 50g of metal tantalum powder (1 micron in diameter), and heat to above 40°C in a water bath. Fully dissolve. Add dropwise to 10 times the amount of liquid paraffin, stir for 20 minutes, add 5% glutaraldehyde solution 80ml, continue to stir for 60 minutes, ice bath for 30 minutes, filter, wash the solid part with absolute ethanol and water alternately for 3 times, freeze-dry, that is have to.

[0036] Microspheres with different particle sizes can be obtained by adjusting the concentration of carboxyl-modified polyvinyl alcohol solution, the ratio of added aldehyde compounds and the ratio of liquid paraffin or vegetable oil.

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Abstract

The invention discloses a developing carboxyl modified polyvinyl alcohol microsphere embolization agent applied to liver cancer tumor embolism. The developing carboxyl modified polyvinyl alcohol microsphere embolization agent disclosed by the invention is characterized by being prepared from three parts of carboxyl modified polyvinyl alcohol, a dispersant and a developing agent according to any proportion. The developing carboxyl modified polyvinyl alcohol microsphere embolization agent has three functions of drug carrying, embolism and developing at the same time. The developing carboxyl modified polyvinyl alcohol microsphere embolization agent can be directly applied to embolism and also can be applied to embolism after medicine carrying; carried medicine is anti-hepatoma medicine; carboxyl modified polyvinyl alcohol polymer is prepared from raw materials of monomer, an initiator and a solvent; the monomer is prepared from vinyl acetate and second comonomer; the second comonomer is one or combination of maleic acid, itaconic acid, pentenedioic acid and itaconic anhydride. By means of continuous polymerization, the carboxyl modified polyvinyl alcohol can be prepared by alcoholysis.

Description

technical field [0001] The invention relates to a developable carboxyl-modified polyvinyl alcohol microsphere embolization agent for interventional treatment of tumor diseases and a preparation process thereof. Background technique [0002] There are about 700,000 new liver cancer patients every year in the world, of which more than 350,000 are in China. China is a big country for liver disease, and it is also a big country for liver cancer. Liver cancer is one of the most common malignant tumors in China, especially in 40-50-year-old men, with a high degree of malignancy. It is second only to lung cancer and ranks second in the mortality rate of malignant tumors. Surgical treatment is critical to health and life. . These include liver transplantation, liver resection; ablation. Ablation is to use physical methods to destroy the tumor in the liver, such as using high temperature, low temperature, and chemical substances. Including radiofrequency ablation, microwave ablat...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00C08F218/08C08F222/02C08F222/04C08F8/00C08J3/24
CPCA61L24/001A61L24/0015A61L24/06C08F8/00C08F218/08C08J3/24C08J2331/04C08L29/04C08F222/02C08F222/04
Inventor 徐平
Owner 杭州华微医疗科技有限公司
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