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Plant capsule shell and preparation method thereof

A plant capsule and carrageenan technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of long disintegration time of capsule shells and unsuitability for drugs, and achieve good mechanical properties and meet the needs of life. desired effect

Pending Publication Date: 2018-03-23
JIANGSU LEFAN CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the capsule shell can enhance the body's physical fitness and improve human immunity, the capsule shell takes a long time to disintegrate and is not suitable for rapid release drugs

Method used

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  • Plant capsule shell and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0022] A vegetable capsule shell, comprising the following components in parts by weight: 18 parts of hydroxypropyl methylcellulose, 0.1 part of K-type carrageenan, 0.2 part of I-type carrageenan, 12 parts of potassium chloride, and 8 parts of magnesium chloride , 2 parts of citronella essential oil, 2 parts of nano titanium dioxide, 12 parts of propylene glycol, 0.1 part of plasticizer, 0.2 part of sorbitol, 12 parts of potassium dihydrogen phosphate, 25 parts of seaweed polysaccharide, 45 parts of purified water. Wherein, the particle size of the nano-titanium dioxide is 10 μm.

[0023] The preparation method of above-mentioned vegetable capsule shell, comprises the following steps:

[0024] Step 1, taking each component by weighing;

[0025] Step 2, add magnesium chloride, potassium chloride, propylene glycol, sorbitol, potassium dihydrogen phosphate, and plasticizer into water, stir to dissolve, then add K-type carrageenan, I-type carrageenan, and seaweed polysaccharide, ...

Embodiment 2

[0029] A vegetable capsule shell, comprising the following components in parts by weight: 20 parts of hydroxypropyl methylcellulose, 2 parts of K-type carrageenan, 6 parts of I-type carrageenan, 15 parts of potassium chloride, and 12 parts of magnesium chloride , 10 parts of citronella essential oil, 5 parts of nano titanium dioxide, 16 parts of propylene glycol, 0.2 parts of plasticizer, 0.4 parts of sorbitol, 13 parts of potassium dihydrogen phosphate, 30 parts of seaweed polysaccharide, 60 parts of purified water. Wherein, the particle size of the nano-titanium dioxide is 10-20 μm.

[0030] The preparation method of above-mentioned vegetable capsule shell, comprises the following steps:

[0031] Step 1, taking each component by weighing;

[0032] Step 2, add magnesium chloride, potassium chloride, propylene glycol, sorbitol, potassium dihydrogen phosphate, and plasticizer into water, stir to dissolve, then add K-type carrageenan, I-type carrageenan, and seaweed polysacchar...

Embodiment 3

[0036] A vegetable capsule shell, comprising the following components in parts by weight: 24 parts of hydroxypropyl methylcellulose, 12 parts of K-type carrageenan, 10 parts of I-type carrageenan, 18 parts of potassium chloride, 8- 18 parts, 17 parts of citronella essential oil, 8 parts of nano titanium dioxide, 18 parts of propylene glycol, 0.5 parts of plasticizer, 0.5 parts of sorbitol, 15 parts of potassium dihydrogen phosphate, 38 parts of seaweed polysaccharide, 64 parts of purified water.

[0037] Wherein, the particle size of the nano-titanium dioxide is 10-20 μm.

[0038] The preparation method of above-mentioned vegetable capsule shell, comprises the following steps:

[0039] Step 1, taking each component by weighing;

[0040] Step 2, add magnesium chloride, potassium chloride, propylene glycol, sorbitol, potassium dihydrogen phosphate, and plasticizer into water, stir to dissolve, then add K-type carrageenan, I-type carrageenan, and seaweed polysaccharide, heat to ...

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Abstract

The invention discloses a plant capsule shell and a preparation method thereof. The capsule shell comprises hydroxypropyl methyl celluloses, K-type carrageenan, I-type carrageenan, potassium chloride,magnesium chloride, lemongrass essence, nano-titania, propanediol, plasticizer, sorbitol, monopotassium phosphate, algal polysaccharides and purified water. The preparation method includes adding themagnesium chloride, the potassium chloride, the propanediol, the sorbitol, the monopotassium phosphate and the plasticizer into water, stirring to dissolve the materials, adding the K-type carrageenan, the I-type carrageenan and the algal polysaccharides, heating to dissolve the materials, adding the hydroxypropyl methyl celluloses and the lemongrass essence, stirring the materials, lowering thetemperature to 45 DEG C after layering, and performing heat insulation and defoaming to obtain capsule gel; soaking a mold pin into the capsule gel, overturning the mold pin for 2-5 times, and performing baking to obtain a single-section capsule; sleeving the capsule with a cap obtained after section cutting to obtain a finished capsule. The capsule shell prepared through compounding of the K-typecarrageenan and I-type carrageenan has good mechanical property, is resistant to high temperature and bacteria, and can be completely disintegrated within 10 minutes.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule preparation, and in particular relates to a plant capsule shell and a preparation method thereof. Background technique [0002] Empty capsules mostly use animal gelatin as the main raw material, and the source of animal gelatin is mostly fermented from animal skin and bone, and a large amount of chemical components are added during the fermentation process, which will cause serious pollution to the air and water environment. In addition, most of the existing vegetable capsules use one or more of K-type carrageenan, gellan gum, konjac gum, xanthan gum, etc. Dispenses quick-release medications. [0003] For example, the application number 201410380757.8 is called a plant health capsule shell, which includes the following components and the mass ratio of each component is: hydroxypropyl methylcellulose: 20-30 parts, carrageenan: 20-30 parts parts, guar gum: 10-25 parts, seaweed polysaccharid...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/44A61K47/02A61K47/26
CPCA61K9/4816A61K47/02A61K47/26A61K47/36A61K47/38A61K47/44
Inventor 茅琦潘婕方忠明朱明英
Owner JIANGSU LEFAN CAPSULE
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