Olanzapine gastric-dissolved type tablet

A stomach-soluble olanzapine technology, applied in pill delivery, nervous system diseases, drug combination, etc., can solve the problems of long production cycle, high material loss, unstable quality of finished products, etc., and achieve short production cycle and high quality of finished products stable effect

Inactive Publication Date: 2018-04-13
GUANGDONG YIMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When wet granulation is used to prepare olanzapine stomach-soluble tablets, there are many production steps, high energy consumption, high material loss, long production cycle, and the introduction of water during the production process, resulting in unstable quality of the finished product during long-term storage

Method used

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Embodiment Construction

[0011] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0012] The invention provides a technical solution: a stomach-soluble olanzapine tablet, which is composed of the following raw materials: olanzapine, xylitol, microcrystalline cellulose, sorbitan fatty acid ester, magnesium stearate, Croscarmellose sodium, magnesium hydroxide, pregelatinized starch.

[0013] Dissolve magnesium sulfate in water with a dissolving ratio of 1:10, raise the temperature to 55°C, and slowly add it to the prepared sodium stearate solution, carry out metathesis reaction under stirring, and the magnesium stearate produced by the reaction will be in the form of solid After the reaction is completed, stand still to separate the clear liquid, then wash with water, centrifugally dehydrate, and dry at 80-85°C to obtain the magn...

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PUM

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Abstract

The invention provides an olanzapine gastric-dissolved type tablet, which is prepared from the following raw materials: olanzapine, xylitol, microcrystalline cellulose, polyoxyethylene sorbitan fattyacid ester, magnesium stearate, croscarmellose sodium, magnesium hydrate and pregelatinized starch. Compared with the prior art, the olanzapine gastric-dissolved type tablet provided by the inventionhas the following beneficial effects of short production period, stable finished product quality, and no moisture absorption phenomenon occurred when being placed in air for a long time.

Description

technical field [0001] The invention relates to an olanzapine stomach-soluble tablet, which belongs to the field of pharmaceuticals. Background technique [0002] Olanzapine is indicated for the acute phase and maintenance treatment of schizophrenia and other psychosis with severe positive and / or negative symptoms. Olanzapine also relieves secondary affective symptoms common in schizophrenia and related disorders. For initial curative effect, continued treatment is required. Olanzapine is an antipsychotic with pharmacological effects on multiple receptor systems. Animal experiments have shown that olanzapine has affinity for multiple receptors such as 5-HT, dopamine D, α-adrenaline, and histamine H. Animal behavior studies have shown that olanzapine has 5-HT, dopamine and cholinergic antagonism, which is consistent with its receptor binding. Olanzapine has a greater affinity for the 5-HT2 receptor in vitro and in vivo than its affinity for the dopamine D2 receptor. Elec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/551A61K47/38A61P25/18
CPCA61K31/551A61K9/2059
Inventor 李易春
Owner GUANGDONG YIMING PHARMA
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