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Calcium and zinc gluconate oral liquid and preparation method thereof

A technology of calcium zinc gluconate and oral solution, applied in the field of medicine, can solve the problems of insufficient stability, easy crystallization and precipitation, high viscosity of the solution, etc., so as to reduce the influence of human blood sugar concentration, reduce safety risks, and achieve fast filtration speed. Effect

Inactive Publication Date: 2018-04-13
HUNAN QIANJIN XIELI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The calcium zinc gluconate oral solution after above-mentioned improvement still has following shortcoming: (1) sucrose sugar content is higher, may cause children's tooth decay, hyperglycemia during pregnancy and senile diabetes, in addition, the high sugar content of sucrose can cause solution viscosity Large, slow filtration of microporous membrane, low production efficiency; in addition, the high sugar content of sucrose leads to supersaturated state of calcium gluconate in oral solution, easy to crystallize and precipitate, and poor stability
(2) Substances such as aspartame, benzoic acid, or sodium benzoate were used. Although the prescription addition amounts of these substances meet the national standards, some experimental studies have proved that aspartame and sodium benzoate have certain physiological toxicity
(3) The stability is not high enough

Method used

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  • Calcium and zinc gluconate oral liquid and preparation method thereof
  • Calcium and zinc gluconate oral liquid and preparation method thereof
  • Calcium and zinc gluconate oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A calcium zinc gluconate oral solution comprises the following components by weight:

[0028]

[0029] The preparation method of above-mentioned calcium zinc gluconate oral solution comprises the following steps:

[0030] (1) Add calcium gluconate after boiling 8L of purified water for 20 minutes, and keep boiling for 10 minutes to obtain reagent 1;

[0031] (2) Add zinc gluconate, lysine hydrochloride, stevioside and penetrant alcohol to the reagent 1 obtained in step (1), and keep the reagent 2 obtained by boiling for 40 minutes;

[0032] (3) Add ethylparaben to the reagent 2 obtained in step (2), keep boiling for 5 minutes, and cool to 40° C. to obtain reagent 3;

[0033] (4) Add lactic acid and essence to the reagent 3 obtained in step (3), then add the remaining purified water, and adjust the pH to 4.0-5.0 with sodium hydroxide to obtain the reagent 4;

[0034] (5) Filter the reagent 4 obtained in step (4) successively with 0.8 μm and 0.45 μm microporous membr...

Embodiment 2～4

[0061] The formula components and preparation methods of Examples 2-4 are the same as those of Example 1, except that the amounts of stevioside, ethylparaben and essence are different, see Table 6 for the specific amounts.

[0062] The calcium zinc gluconate oral solution obtained by using the formulations in Examples 1-4 was tested for mouthfeel and aroma, and the results are shown in Table 6 below.

[0063] Table 6: Experimental results (parts by weight) of different amounts of stevia, ethylparaben and essence

[0064]

[0065] In the above table, flavors include but not limited to apple flavor and sweet orange juice flavor. From the experimental results in the above table, it can be seen that the weight ratio of stevioside, essence and relieving alcohol is 12:12:14 and the experimental effect is the best.

Embodiment 5

[0067] The formulation components and preparation method of Example 5 are the same as those of Example 1, except that the amount of ethylparaben is different, see Table 7 for the specific amount.

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Abstract

The invention provides calcium and zinc gluconate oral liquid, which is prepared from the following ingredients in parts by weight: 500 to 600 parts of calcium gluconate, 20 to 40 parts of zinc gluconate, 80 to 120 parts of lysine hydrochloride, 100 to 140 parts of lactic acid, 10 to 14 parts of steviosin, 10 to 16 parts of freshener, 4 to 5 parts of ethylparaben, 10 to 16 parts of essence, 5 to 6parts of sodium hydroxide and 8000 to 12000 parts of purified water. The invention also provides a preparation method of the calcium and zinc gluconate oral liquid. All ingredients achieve a synergiceffect and are finally prepared to obtain the calcium and zinc gluconate oral liquid with higher stability and safety performance.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an oral solution for calcium and zinc supplementation and a preparation method thereof. Background technique [0002] Calcium Zinc Gluconate Oral Solution is a marketed drug, and its indications are diseases caused by calcium deficiency and zinc, including osteoporosis, tetany, rickets, calcium supplementation for pregnant women, lactating women and menopausal women, And children's growth retardation, anorexia, anorexia, recurrent oral ulcers and acne. The traditional prescription is: calcium gluconate 60g, zinc gluconate 3g, lysine hydrochloride 10g, sucrose 100g, sodium chloride 0.1g, essence 1.2g, sodium hydroxide amount, purified water to 1000ml. In recent years, some studies have improved the prescription, changing the flavoring agent in the prescription to aspartame and acesulfame-K alone or in combination with aspartame and acesulfame-K, and adding benzoic acid or sodiu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K9/00A61K47/12A61K47/14A61K47/26A61P19/10A61P43/00A61P19/08A61P3/14A61P1/14A61P1/02A61P17/10A61K31/191A61K31/198
CPCA61K33/30A61K9/0095A61K31/191A61K31/198A61K47/12A61K47/14A61K47/26A61K2300/00
Inventor 任超张泽昀谭喜平肖佳
Owner HUNAN QIANJIN XIELI PHARMA CO LTD
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