External abamectin transdermal agent and preparation method thereof

A technology of abamectin and transdermal agent, which is applied in the field of external abamectin transdermal agent and its preparation, can solve the problems of inconvenient route of administration, large first-pass effect, etc., and achieve avoidance of hepatic first-pass effect and Gastrointestinal inactivation, high safety, and the effect of reducing individual differences

Inactive Publication Date: 2018-04-20
湖北回盛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a kind of abamectin transdermal agent that promotes drug transdermal absorption and preparation method thereof, solves the shortcoming that general abamectin prepar

Method used

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  • External abamectin transdermal agent and preparation method thereof
  • External abamectin transdermal agent and preparation method thereof
  • External abamectin transdermal agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of abamectin transdermal agent for external use and preparation method thereof, comprising the steps of: accurately weighing the abamectin B of formula quantity 1 , add 95% ethanol and stir to dissolve, then add azone, dimethyl sulfoxide, butylated hydroxyanisole (BHA) and stir evenly, and adjust the volume of soybean oil to 100 mL. The specific addition amount is shown in Table 1.

[0025] Table 1 A kind of Abamectin transdermal agent for external use prepares raw materials and its addition amount

[0026]

Embodiment 2

[0028] A kind of abamectin transdermal agent for external use and preparation method thereof, comprising the steps of: accurately weighing the abamectin B of formula quantity 1 , add isopropanol and stir to dissolve, then add azone, decylmethyl sulfoxide, butylated hydroxytoluene (BHT) and stir evenly, and dilute monoglyceride laurate to 100mL. The specific addition amount is shown in Table 2.

[0029] Table 2 A kind of external use Abamectin transdermal agent preparation raw material and its addition amount

[0030]

Embodiment 3

[0032] A kind of abamectin transdermal agent for external use and preparation method thereof, comprising the steps of: accurately weighing the abamectin B of formula quantity 1 , add ethyl oleate and stir to dissolve, then add azone, isopropyl myristate, and propyl gallate (PG) in sequence, stir evenly, and adjust the volume to 100 mL with propylene glycol. The specific addition amount is shown in Table 3.

[0033] Table 3 A kind of external use abamectin transdermal agent preparation raw material and its addition amount

[0034]

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PUM

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Abstract

The invention discloses an external abamectin transdermal agent. The external abamectin transdermal agent comprises the following raw materials in percent by mass: 0.5 percent of abamectin B1, 3 to 8percent of azone, 0.5 to 6 percent of a penetrating agent, 0.002 to 0.1 percent of an antioxidant, 30 to 80 percent of an emulgator, and the balance of an organic solvent. The invention further provides a preparation method of the external abamectin transdermal agent. The abamectin transdermal agent is dosed in mode of being poured to or embrocated to a body surface, is convenient to use and highin safety; and secondly, the abamectin transdermal agent adopts the optimal formula combining azone and the penetrating agent in terms of a preparation formula, and can obviously improve the transdermal effect. For cows and pigs, the abamectin transdermal agent is poured from shoulders to rear parts along dorsal lines; and for dogs and rabbits, the abamectin transdermal agent is embrocated on theinner sides of ears. As the method of administration is unique, stimulation of medicine is reduced while curative effect is realized. The abamectin transdermal agent can be applied to the treatment ofnemathelminthiasis, acariasis and parasitic entomiasis of livestock and poultry.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to an abamectin transdermal agent for external use and a preparation method thereof. The transdermal agent can effectively resist nematode diseases, mite diseases and parasitic insect diseases of livestock and poultry. Background technique [0002] Livestock and poultry nematode diseases, mite diseases and parasitic insect diseases have many types and wide distribution of pathogens, which will not only endanger the health of animals and cause various diseases of livestock and poultry; they will also affect the growth and reproduction of livestock and poultry, and in severe cases will cause A large number of poultry died, bringing huge economic losses to animal husbandry. For example, echinococcosis parasitizes in the liver of animals, which will cause obvious compression symptoms in the liver tissue and abdominal cavity; when there are too many roundworms in the intestin...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/22A61K31/7048A61P33/14A61P33/10A61P33/00
CPCA61K9/0014A61K31/7048A61K47/22Y02A40/70
Inventor 杨飞赵志锦张永丹刘洁姜锋董依玲付列民
Owner 湖北回盛生物科技有限公司
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