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Piperaquine phosphate oral liquid and preparation method thereof

A kind of piperaquine phosphate oral liquid and piperaquine phosphate technology, applied in the field of medicine, can solve problems such as slow drug effect development time, and achieve the effects of low production process cost, low production cost, and improved quality and taste

Inactive Publication Date: 2018-04-20
GUILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] From the currently disclosed literature about piperaquine phosphate clinical treatment of malaria, especially for the treatment and prevention of falciparum malaria caused by chloroquine-resistant strains, the dosage form of piperaquine phosphate has only oral tablets, such as piperaquine phosphate tablet (sugar-coated tablets) and dihydropiperaquine tablets (film tablets), since the tablets first need to disintegrate in the digestive juice after entering the digestive tract to release the drug before it can be absorbed, so the drug effect is relatively slow

Method used

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  • Piperaquine phosphate oral liquid and preparation method thereof
  • Piperaquine phosphate oral liquid and preparation method thereof
  • Piperaquine phosphate oral liquid and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Weigh 10 g of piperaquine phosphate, add 50 mL of purified water, 10 g of ethanol, stir in a water bath at 50°C to 60°C to disperse evenly, add hydrochloric acid dropwise to control pH 2.5, dissolve piperaquine phosphate to obtain a transparent solution of piperaquine phosphate , add 0.5g sucralose and 0.1g butylated hydroxytoluene, keep at 50-60°C for 15 minutes, filter and cool to room temperature, add water to volume to 150mL to obtain a clear solution, which is divided into brown bottles, filtered, divided into Sterilize at 115°C for 20 min to prepare oral liquid.

Embodiment 2

[0062] Weigh 10 g of piperaquine phosphate, add 100 mL of purified water, 10 g of ethanol, stir in a water bath at 50°C to 60°C to make it evenly dispersed, add hydrochloric acid dropwise to control pH 2.5, dissolve piperaquine phosphate to obtain a transparent piperaquine phosphate solution , add 0.5g of sucralose and 0.1g of butylated hydroxytoluene, keep at 50-60°C for 15 minutes, filter and cool to room temperature, add water to make up to 200mL to obtain a clear solution, which is divided into brown bottles, filtered, divided into Sterilize at 115°C for 20 min to prepare oral liquid.

Embodiment 3

[0064] Weigh 10 g of piperaquine phosphate, add 100 mL of purified water, 10 g of ethanol, stir in a water bath at 50°C to 60°C to make it evenly dispersed, add hydrochloric acid dropwise to control pH 3.0, dissolve piperaquine phosphate to obtain a transparent piperaquine phosphate solution , add 0.5g of sucralose and 0.1g of butylated hydroxytoluene, keep at 50-60°C for 15 minutes, filter and cool to room temperature, add water to make up to 200mL to obtain a clear solution, which is divided into brown bottles, filtered, divided into Sterilize at 115°C for 20 min to prepare oral liquid.

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Abstract

The invention provides piperaquine phosphate oral liquid and a preparation method thereof. The piperaquine phosphate oral liquid is prepared from the following components in parts by weight: 1 part ofpiperaquine phosphate, 5-15 parts of water, 1-2 parts of ethanol and a pH regulator; the pH value of the oral liquid is 2.5-4. The preparation method comprises the following steps: mixing piperaquinephosphate, water and ethanol, and regulating the pH value to 2.5-4 by use of the pH regulator to obtain a piperaquine phosphate solution; adding the rest raw materials into the solution to obtain theproduct. The oral liquid provided by the invention has the advantages of relatively fast absorption, stable quality and the like, and is suitable for the old people, children and patients suffering dysphagia, and is easy to take; moreover, with strong efficacy, the oral liquid is a good substitute of piperaquine phosphate tablets.

Description

technical field [0001] The invention relates to the field of medicine, in particular to piperaquine phosphate oral liquid and a preparation method thereof. Background technique [0002] Piperaquine phosphate is a bisquinoline antimalarial drug, and its antimalarial effect is similar to that of chloroquine. In the late 1970s, piperaquine phosphate was used for the first time in the prevention of non-immune people in my country. Currently, piperaquine is well tolerated, inexpensive, and effective as a participating drug in artemisinin-based combination therapy (ACT). In Africa, dihydroartemisinin-piperaquine compared with artemether-benfluorenol reduced overall treatment failure, although the PCR-corrected failure rate for both combinations was less than 5%; in Asia, dihydroartemisinin -The effectiveness of piperaquine is similar to that of artesunate plus mefloquine, and it is well tolerated. [0003] Animal experiments found that the ED50 of piperaquine phosphate in mice ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/26A61K47/36A61K47/42A61P33/06
CPCA61K9/0095A61K31/496A61K47/26A61K47/36A61K47/42
Inventor 郑清四黄军李茗枫黎昌贵张浩
Owner GUILIN PHARMA
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