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Vitamin effervescent preparation and preparation method thereof

An effervescent preparation and vitamin technology, applied in the field of health care products, can solve the problems of turbid calcium tartrate precipitation, low tableting rate, easy moisture absorption, etc., and achieve the effects of no foaming, high tableting rate, and low hygroscopicity.

Active Publication Date: 2021-03-23
郑州拓洋生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When preparing effervescent tablets by dry method, if citric acid or malic acid is used as the acid source, they will easily absorb moisture because of their strong hygroscopicity, resulting in sticky tableting and low tablet yield; if tartaric acid is used as the acid source , when effervescent in water containing calcium ions, calcium tartrate will precipitate and cause turbidity

Method used

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  • Vitamin effervescent preparation and preparation method thereof
  • Vitamin effervescent preparation and preparation method thereof
  • Vitamin effervescent preparation and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0052] In the second aspect, a method of preparing the above vitamin effervescent preparation is provided in at least one embodiment, including the step of: first mixing each raw material of the recipe amount, then a tablet or granulation to obtain the solennator . The preparation method of the above vitamin foam preparation is simple, suitable for large quantities of production, the resulting vitamin foam preparations, no bubble, low hygroscopic, and the effluent is clear and transparent. In particular, there is no sticky phenomenon in the process of the tablets, the sheet is good, the appearance is smooth and smooth, and the phenomenon of fireless sheet is long.

[0053] Preferably, the step of being sieves each of the raw materials is further included, and the screen is preferably from 100 to 150 mesh. The sieve ensures that the particle size of each raw material is substantially at the same level, thereby facilitating subsequent tablets or granulation.

Embodiment 1

[0056] (1) prescription

[0057] According to the mass parts: 115 parts of nitaminic acid, 48 sodium bicarbonate, 4.8 sodium carbonate, 29 sucrose, 3 of PEG-6000, and 5 orange flavors.

[0058] (2) Preparation method

[0059] After the above material is pulverized, the 120 mesh is used, respectively, and the mixed uniform table is compressed.

[0060] (3) Test

[0061] The isometrin C-effervescent prepared in step (2) were placed in water (15 ° C, 100 mL) to disintegrate experiments, and the results are shown in Table 1.

[0062] As a result, it was discovered that the amount of the effervescent of the effervested tablets were more than 85%, and the solution was disintegrated in 1.5 min, and the pH of the solution was ranked from 4.0 to 4.3, and the hardness of the effervation sheet was 5 to 10 kGN.

[0063] Table 1:10 Batch effervescent tablets, disintegration time, etc.

[0064]

[0065] The results show that the effervescent sheets are good in the production process, and ther...

Embodiment 2

[0072] prescription:

[0073] According to the mass parts: 105 parts of nitaminic acid, 45 sodium bicarbonate, 4.5 sodium carbonate, 26 sucrose, 3 parts of PEG-6000, and 2 protein sugar.

[0074] The preparation method and test method were the same as in Example 1, and the test results were shown in Table 3 and Table 4.

[0075] Table 3:10 Batch effervescent tablets, disintegration time, etc.

[0076]

[0077]

[0078] Table 4: Foam Stability Test Results

[0079]

[0080]

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Abstract

The invention relates to the field of health-care products, and particularly provides a vitamin effervescent preparation and a preparation method thereof. The vitamin effervescent preparation mainly adopts D-Isoascorbic acid as an acid source. The vitamin effervescent preparation provided by the invention mainly adopts the D-Isoascorbic acid as the acid source, and the D-Isoascorbic acid does notabsorb moisture easily, so that during dry-method tabletting, sticking is not caused, tablet shapes are good, the tablet forming rate is high, the obtained effervescent preparation does not absorb moisture easily and is not wetted easily, when the effervescent preparation is effervescent in water containing calcium ions, precipitate cannot be produced, and effervescent fluid is clear and transparent; and the D-Isoascorbic acid is a green and efficient antioxidant, so that the effervescent preparation is good in stability and is not liable to oxidize to become invalid in the storage process.

Description

Technical field [0001] The present invention relates to the field of health care products, and in particular, there is a vitamin residue agent and a preparation method thereof. Background technique [0002] The effervescent agent is a solid preparation containing the residualization agent. The so-called effervescent disintegration agent is typically a mixture of an organic acid and sodium bicarbonate (baking soda); and when the effervescent tablet is placed in water, an organic acid and sodium bicarbonate in water under the action of ionization, and the metathesis reaction to produce a large amount Carbon dioxide makes the tablet rapidly disintegrates and melts, and sometimes the bubbles generated by the disintegration will also roll the tablets to the water, accelerate their disintegration and melting; the carbon dioxide part produced during disintegration is dissolved in drinking water, so that drinking water There is a beautiful beauty of soda. Compared to conventional common ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/15A23L2/40A23L2/52A23L2/60A23L33/16
CPCA23L2/40A23L2/52A23L2/60A23V2002/00A23L33/15A23L33/16A23V2200/324A23V2200/308A23V2200/30
Inventor 周俊俊秦天仓王敬臣龚舒张抗张生克肖媛李月番张建国赵建波徐琳崔凤霞曹琳青曹晓伟高莉刘银霞
Owner 郑州拓洋生物工程有限公司
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