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Doramectin nanometer emulsifier for livestock and preparation method thereof

A technology of doramectin and nanoemulsion, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problems of short duration of drug efficacy, reduction of breeding costs, and insufficient absorption And other problems, to achieve the effect of good fluidity, lower production costs, and less irritation

Inactive Publication Date: 2018-05-04
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently commercially available doramectin injection, because it is an injection prepared by dissolving in a pure organic solvent, has obvious pain and greater stimulation to animals after injection, and it also has a short duration of single administration. Repeated administration is required; insufficient absorption and other shortcomings, so the development of a veterinary doramectin nanoemulsion with less irritation and longer-lasting curative effect can reduce animal pain and stress, reduce the number of administrations, and reduce breeding costs

Method used

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  • Doramectin nanometer emulsifier for livestock and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Preparation method: Accurately weigh 0.8g of qualified doramectin raw material and feed it at 100.0%, stir and dissolve it with 45ml ethyl oleate, after it dissolves, add Tween-80 and isopropanol mixed in a ratio of 6:1 55ml of alcohol, then put it into a homogenizer for mechanical stirring and dispersion, and then use ultrasonic waves for 18 minutes. After the liquid becomes clear, add water for injection to the full amount and stir evenly to obtain a nanoemulsion with blue opalescence , after passing the inspection, it is subpackaged, covered, labeled, packed, inspected, and put into storage.

Embodiment 2

[0022] Preparation method: Accurately weigh 10g of the qualified doramectin raw material and feed it at 100.0%, stir and dissolve it with white oil mixed with 1:2 ratio for injection and ethyl acetate 60ml, after it dissolves, add it at a ratio of 4:1 Mixed Tween-80 and glycerol 30ml, then put into a homogenizer for mechanical stirring and dispersion, and then use ultrasonic waves for 20 minutes, after the liquid becomes clear, add water for injection to the full amount and stir evenly to obtain Nanoemulsion with blue opalescence, after passing the inspection, it is subpackaged, covered, labeled, boxed, inspected, and put into storage.

Embodiment 3

[0024] Preparation method: Accurately weigh 20 g of qualified doramectin raw materials and feed at 100.0%, stir and dissolve it with 60 ml of benzyl benzoate and ethyl acetate mixed in a ratio of 1:2 for injection, and after it dissolves, add according to 3: Mix 60ml of polyvinylpyrrolidone and glycerol in a ratio of 1, then put it into a homogenizer for mechanical stirring and dispersion, and then use ultrasonic waves for 20 minutes. After the liquid becomes clear, add water for injection to the full amount and stir evenly. The nanoemulsion with blue opalescence is obtained, and after passing the inspection, it is subpackaged, covered, labeled, boxed, inspected, and put into storage.

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Abstract

The invention discloses a doramectin nanometer emulsifier for livestock and a preparation method thereof. The doramectin nanometer emulsifier is prepared from the following main component in percentage by mass: 0.08% to 2% of doramectin. The doramectin nanometer emulsifier has the advantages that the novel nanometer dispersing technique is adopted, so that the property of the prepared product is more stable; because the novel nanometer dispersing technique is applied, the particle size of the emulsifier droplet can be accurately controlled within the dynamic range of 30 to 90nm, the releasingspeeds of different particle sizes are different in the body, the medicine can be absorbed and discharged in the body at zero-level rate, and the maintaining time is one week, one month or 0.5 year; by adjusting the dosage time and dosage amount, the medicine can be completely discharged before the animal is killed, so that the effect of expelling and killing the parasites inside and outside the animal body is realized for a long time; the convenience in use is realized, and the healing rate is high; compared with the similar products, the treatment effect is better, and the cost is lower.

Description

technical field [0001] The present invention relates to a veterinary preparation technology, in particular to a veterinary doramectin nanoemulsion and a preparation method thereof. Background technique [0002] Doramectin is a kind of high-efficiency, broad-spectrum, macrolide antiparasitic drug available to pregnant animals. The currently commercially available doramectin injection, because it is an injection made by dissolving pure organic solvents, has obvious pain and greater stimulation to animals after injection, and it also has a short duration of single administration to maintain the drug effect. Repeated administration is required; insufficient absorption and other shortcomings, for this reason, the development of a veterinary doramectin nanoemulsion with less irritation and longer-lasting curative effect can reduce animal pain and stress, reduce the number of administrations, and reduce breeding costs. Contents of the invention [0003] The object of the present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61K47/14A61K47/44A61P33/00
CPCA61K31/7048A61K9/0019A61K9/1075A61K47/14A61K47/44
Inventor 曾杨梅吴俊伟陈红伟姜波邓开锋罗娟
Owner CHONGQING BULL ANIMAL PHARMA