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Method for extracting astragaloside and astragalus polysaccharide under assistance of steam explosion

A technology of astragaloside and auxiliary extraction, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of low extraction efficiency of active ingredients, increase of extraction cost, limited degree of damage, etc., and shorten the extraction time , Improve the dissolution efficiency, improve the effect of porous characteristics

Inactive Publication Date: 2018-05-04
北京中科百瑞能工程技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional method generally adopts mechanical crushing to pretreat the Astragalus membranaceus. However, due to the mechanical resistance of the dense structure of Astragalus membranaceus, the degree of damage to plant cells by mechanical treatment is limited, and the extraction efficiency of active ingredients is low; if Astragalus membranaceus Crushed to powder, it will increase energy consumption and increase extraction cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Cut the Astragalus medicinal material to 3-5 cm, add water according to the mass ratio of the dry Astragalus medicinal material to water 1:1, and then soak and rehydrate at room temperature for 4 h; put the rehydrated material in a steam explosion tank, pass Add steam to make the pressure in the tank reach 1.2 MPa, maintain the pressure at 1.2 MPa for 5 min, and then carry out steam explosion treatment; add 90°C water 10 times its absolute dry mass to the material after steam explosion, extract once, 1 hour each time, combine water Extraction: After the water extract is evaporated under reduced pressure, ethanol is added to make the alcohol content reach 80%, and precipitation occurs at the same time, and the precipitated part and the supernatant are separated and purified to obtain polysaccharide and saponin components respectively. The porosity, pore volume and average pore diameter of the steam-exploded Astragalus material were 68.88%, 1.473% and 10332 nm, while those...

Embodiment 2

[0011] Cut the Astragalus medicinal material to 3-5 cm, add water according to the mass ratio of the dry Astragalus medicinal material to water 1:4, and then soak and rehydrate at room temperature for 12 h; put the rehydrated material in a steam explosion tank, pass Add steam to make the pressure in the tank reach 1.8 MPa, and then carry out steam explosion treatment after maintaining for 15 minutes; add 100°C water 20 times its absolute dry mass to the material after steam explosion, extract 3 times, 2 hours each time, and combine the water extracts; After the water extract is evaporated to dryness under reduced pressure, absolute ethanol is added, and precipitation occurs at the same time, and the precipitated part and the supernatant are separated and purified to obtain polysaccharide and saponin components respectively. The porosity, pore volume and average pore diameter of the steam-exploded Astragalus material were 70.17%, 2.072 ml / g and 41265 nm, while those of the origi...

Embodiment 3

[0013] Cut the medicinal material of Astragalus membranaceus to 3~5 cm, put it in the steam explosion tank according to the method of the medicinal material of Astragalus membranaceus, introduce steam to make the pressure in the tank reach 0.6MPa, keep it for 1 min, and carry out steam explosion treatment; add the dry mass of the material after steam explosion 5 times of water at 60°C, extract once, 1 hour each time, and combine the water extracts; evaporate the water extracts under reduced pressure, add ethanol to make the alcohol content reach 50%, and precipitate at the same time, the precipitated part and the supernatant are separated by The polysaccharide and saponin components were obtained by purification. The porosity, pore volume and average pore diameter of the steam-exploded Astragalus material were 49.03%, 0.701 ml / g and 1913 nm, while those of the original non-steamed Astragalus material were 48.43%, 0.629 ml / g and 272.6 nm. and polysaccharide extraction rates rea...

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Abstract

The invention discloses a method for extracting astragaloside and astragalus polysaccharide under assistance of steam explosion to fundamentally eliminate the influence of a compact structure of cellwalls of radix astragali on dissolution of effective ingredients of radix astragali and improve the dissolution efficiency of a radix astragali extract. The method comprises steps as follows: the radix astragali material is put in a steam explosion pot after being rehydrated, saturated steam is introduced, certain pressure is kept, and pressure relief is performed after a period of time; a raw material after steam explosion is collected and subjected to extraction with hot water, a water extraction solution is subjected to precipitation separation extraction with ethanol, astragaloside and polysaccharide are obtained, and astragalus polysaccharide and astragaloside are obtained respectively after separation purification of a precipitate and a liquid supernatant. The steam explosion technology is used for treating the radix astragali, so that the material is subjected to hemicellulose decomposition, softening and partial dissolution of lignin as well as fiber structure loosening, the cell walls of radix astragali are effectively damaged, an obvious porous structure is formed, the dissolution rate of the effective ingredients is increased without damaging the structure and activity of the ingredients. Compared with conventional crushing extraction, the method has the advantages that the yields of astragaloside and astragalus polysaccharide are increased by 2.8 times and 4.5 timesrespectively, and the extraction time is shortened by at least one half.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicine processing, and in particular relates to a steam explosion-assisted extraction method of astragalus saponin and astragalus polysaccharide. Background technique [0002] Astragalus, first recorded in "Shen Nong's Materia Medica", a common leguminous Astragalus genus, perennial herbal Chinese medicinal materials, produced in Northeast China, North China, Shanxi, Gansu and other places, cultivated Mongolian Astragalus membranaceus ( Fisch. ) Bge.var . mongholicus ( Bge. ) Hsiao and A. membranceus ( Fisch. ) Bge. are the original plant germplasm. The medicinal history of Astragalus membranaceus has reached more than 2,000 years since ancient times. The medicinal value of its underground taproot is mainly reflected in nourishing qi and strengthening the surface, diuresis and sores, strengthening the heart and lowering blood pressure, etc. It is widely used in clinical practice. Astrag...

Claims

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Application Information

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IPC IPC(8): A61K36/481C08B37/00
CPCA61K36/481A61K2236/331A61K2236/53C08B37/0003
Inventor 不公告发明人
Owner 北京中科百瑞能工程技术有限责任公司
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