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Albumin-loaded metalloporphyrin complex nano particles preparation method and application thereof

A technology of porphyrin complexes and nanoparticles, which is applied in the field of preparation of albumin-loaded metalloporphyrin complex nanoparticles, can solve the problems of short cycle time and poor solubility of metalloporphyrin complexes, and achieve the goal of avoiding harm and good dissolution Sex and targeting, and the effect of simple preparation method

Active Publication Date: 2018-05-15
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of metalloporphyrin complexes, such as poor solubility and short cycle time, limit their translation to clinical applications.

Method used

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  • Albumin-loaded metalloporphyrin complex nano particles preparation method and application thereof
  • Albumin-loaded metalloporphyrin complex nano particles preparation method and application thereof
  • Albumin-loaded metalloporphyrin complex nano particles preparation method and application thereof

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preparation example Construction

[0086] It can also be clearly known from the above preparation method of the present invention that, in the synthesis process of albumin-loaded metalloporphyrin complex nanoparticles, the present invention does not need to add additional chemical linkers, and only needs to combine the metalloporphyrin complex with albumin It only needs to mix ultrasound, and the two can be self-assembled through covalent bonding, thereby forming a loaded composite structure; compared with the traditional preparation method of albumin-loaded drugs, the method of the present invention is also more convenient in operation;

[0087]By introducing a coordinated central metal into porphyrin / porphyrin derivatives, the solubility of porphyrin can be improved; at the same time, due to the attraction of the coordinated metal ion to the large π bond of the porphyrin ring, the porphyrin can be improved. The transition performance of π electrons on the phylloline ring makes the prepared complexes have the e...

Embodiment example 1

[0092] (1) Preparation of Zn-TTP complex

[0093] With 67mg of TTP (i.e. R in formula (III) 5 = R 6 = R 7 = R 8 =methyl) was dissolved in 15mL tetrahydrofuran solution, and 5ml methanol solution of 36mg zinc acetate was dissolved in the above-mentioned solution;

[0094] Nitrogen gas was introduced to remove the air in the system, and then heated and stirred at 65° C. under the protection of a nitrogen balloon, and the progress of the reaction was monitored by UV, and the reaction was stopped after 1.5 h. Add 50 mL of ice water to the reaction system, refrigerate overnight, and filter with suction to obtain 89 mg of brown-red solid powder;

[0095] The resulting solid product was dissolved in chloroform, separated and purified by gel column chromatography, and the mobile phase used was methanol to obtain a primary purified product; then the primary purified product was dissolved in chloroform, and the precipitate was dissolved in chloroform, and the silica gel column layer...

Embodiment 1

[0098] The preparation process of embodiment 1 can refer to figure 1 .

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Abstract

The invention provides albumin-loaded metalloporphyrin complex nano particles preparation method and an application thereof. The albumin-loaded metalloporphyrin complex nano particles take porphyrin,metal salt and albumin as raw materials, a solvent method is employed for preparing the albumin-loaded metalloporphyrin complex nano particles, the method is simple, operation is easy, repeatability is good, and the prepared albumin-loaded metalloporphyrin complex nano particles solve the problem of water solubility and targeting performance of a metal-based complex medicine; under supersonic waveeffect, the albumin-loaded metalloporphyrin complex nano particles have ultrasonic tumor cell killing effect, and a metal-based complex loaded on albumin molecules has a wide antineoplastic application prospect.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to a preparation method and application of albumin-loaded metalloporphyrin complex nanoparticles. Background technique [0002] In the 1960s, the discovery of the anticancer activity of cisplatin opened up a new field of research on metal complex anticancer drugs. Metal ions are closely related to fields such as medicine, life science, and environmental science. In organisms, metal ions such as iron, cobalt, nickel, copper, and zinc are widely involved in life processes. They are essential elements for maintaining life activities and an indispensable part of human health and life activities. The biggest feature of metals is that they can lose electrons to become positively charged ions, and then produce various bonds with biomolecules to form enzymes, hormones, vitamins, etc., thereby exerting important physiological functions. With the continuous deepening of the research on the me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/14A61K9/51A61K49/18A61K47/42A61P35/00B82Y5/00B82Y15/00
CPCA61K9/5169A61K41/0033A61K49/143A61K49/1818B82Y5/00B82Y15/00
Inventor 蔡林涛马爱青陈华清郑明彬罗震宇田浩梁锐晶陈志宽韩志群
Owner SHENZHEN INST OF ADVANCED TECH
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